Patents by Inventor Maksym A. Vodyanyk

Maksym A. Vodyanyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ERYTHROID CELLS PRODUCING ADULT-TYPE BETA-HEMOGLOBIN GENERATED FROM HUMAN EMBRYONIC STEM CELLS
    Publication number: 20140248699
    Abstract: Methods and compositions of erythroid cells that produce adult ?-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
    Type: Application
    Filed: March 13, 2012
    Publication date: September 4, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Method of forming dendritic cells from embryonic stem cells
    Patent number: 8785189
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: July 22, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Endothelial cell production by programming
    Patent number: 8785192
    Abstract: The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: July 22, 2014
    Assignee: Cellular Dynamics International, Inc.
    Inventors: Junying Yu, Maksym A. Vodyanyk
  • HEMATOPOIETIC PRECURSOR CELL PRODUCTION BY PROGRAMMING
    Publication number: 20140037600
    Abstract: The invention generally regards methods for providing ematopoietic cells and precursors of hematopoietic cells from a variety of cell sources, such as pluripotent stem cells or somatic cells. Also provided are therapeutic compositions including the provided hematopoietic cells and precursors of hematopoietic cells, and methods of using such for the treatment of subjects.
    Type: Application
    Filed: February 7, 2012
    Publication date: February 6, 2014
    Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC.
    Inventors: Junying Yu, Maksym A. Vodyanyk
  • HEPATOCYTE PRODUCTION BY FORWARD PROGRAMMING
    Publication number: 20130251694
    Abstract: The invention generally features methods for providing hepatocytes from a variety of cell sources, particularly pluripotent stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects.
    Type: Application
    Filed: June 5, 2013
    Publication date: September 26, 2013
    Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC.
    Inventors: Junying YU, Fongching Kevin CHAU, Jinlan JIANG, Yong JIANG, Maksym A. VODYANYK
  • Method of Forming Dendritic Cells from Embryonic Stem Cells
    Publication number: 20130230917
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Application
    Filed: April 9, 2013
    Publication date: September 5, 2013
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Hepatocyte production by forward programming
    Patent number: 8481317
    Abstract: The invention generally features methods for providing hepatocytes from a variety of cell sources, particularly pluripotent stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: July 9, 2013
    Assignee: Cellular Dynamics International, Inc.
    Inventors: Junying Yu, Fongching Kevin Chau, Jinlan Jiang, Yong Jiang, Maksym A. Vodyanyk
  • Method of forming dendritic cells from embryonic stem cells
    Patent number: 8435785
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: May 7, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Angiohematopoietic Progenitor Cells
    Publication number: 20130058905
    Abstract: A purified human cell population of subsets of angiohematopoietic progenitor cells, wherein the population is at least 94% pure and wherein the cells are selected with cell markers selected from the group of KDR, APLNR, VE-cadherin, PDGFR?, CD31, CD235a, CD73, CD43, and CD41a.
    Type: Application
    Filed: August 21, 2012
    Publication date: March 7, 2013
    Inventors: Igor Slukvin, Maksym Vodyanyk, Kyung-Dal Choi
  • Method Of Forming Dendritic Cells From Embryonic Stem Cells
    Publication number: 20120142106
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Application
    Filed: February 1, 2012
    Publication date: June 7, 2012
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Erythroid cells producing adult-type ?-hemoglobin generated from human embryonic stem cells
    Patent number: 8158422
    Abstract: Methods and compositions of erythroid cells that produce adult ?-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.
    Type: Grant
    Filed: February 8, 2007
    Date of Patent: April 17, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Method of forming myeloid precursor cells from human embryonic stem cells
    Patent number: 8133732
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: March 13, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • Multipotent Lymphohematopoietic Progenitor Cells
    Publication number: 20120040362
    Abstract: This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to produce differentiated cells of the lymphoid lineages.
    Type: Application
    Filed: July 29, 2011
    Publication date: February 16, 2012
    Inventors: Igor I. Slukvin, Maksym A. Vodyanyk, James A. Thomson
  • ENDOTHELIAL CELL PRODUCTION BY PROGRAMMING
    Publication number: 20120009618
    Abstract: The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects.
    Type: Application
    Filed: July 7, 2011
    Publication date: January 12, 2012
    Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC.
    Inventors: Junying Yu, Maksym A. Vodyanyk
  • HEPATOCYTE PRODUCTION BY FORWARD PROGRAMMING
    Publication number: 20110280844
    Abstract: The invention generally features methods for providing hepatocytes from a variety of cell sources, particularly pluripotent stem cells, therapeutic compositions featuring such cells, and methods of using them for the treatment of subjects.
    Type: Application
    Filed: April 13, 2011
    Publication date: November 17, 2011
    Applicant: Cellular Dynamics International, Inc.
    Inventors: Junying Yu, Fongching Kevin Chau, Jinlan Jiang, Yong Jiang, Maksym A. Vodyanyk
  • Multipotent lymphohematopoietic progenitor cells
    Patent number: 8034613
    Abstract: This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to produce differentiated cells of the lymphoid lineages.
    Type: Grant
    Filed: September 14, 2006
    Date of Patent: October 11, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Maksym A. Vodyanyk, James A. Thomson
  • Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions
    Publication number: 20110236971
    Abstract: Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions are disclosed
    Type: Application
    Filed: March 18, 2010
    Publication date: September 29, 2011
    Inventors: Maksym Vodyanyk, Igor Slukvin
  • Method of Forming Dendritic Cells from Embryonic Stem Cells
    Publication number: 20110117135
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Application
    Filed: September 7, 2010
    Publication date: May 19, 2011
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk
  • GENERATION OF CLONAL MESENCHYMAL PROGENITORS AND MESENCHYMAL STEM CELL LINES UNDER SERUM-FREE CONDITIONS
    Publication number: 20100261274
    Abstract: Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions are disclosed.
    Type: Application
    Filed: March 18, 2010
    Publication date: October 14, 2010
    Inventors: Maksym A. Vodyanyk, Igor I. Slukvin
  • Method of forming dendritic cells from embryonic stem cells
    Patent number: 7811821
    Abstract: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: October 12, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, James A. Thomson, Maksym A. Vodyanyk, Maryna E. Gumenyuk