Patents by Inventor Manfred Weigele

Manfred Weigele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorogenic 2-oxy-3(2H)-furanone materials
    Patent number: 3969373
    Abstract: Compounds of the formula ##SPC1##Wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: June 26, 1975
    Date of Patent: July 13, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Preparation of dialkyl amino acrylonitrile
    Patent number: 3966791
    Abstract: A process for preparing dialkyl amino acrylonitrile by condensing acetonitrile and an acetal of dimethyl formamide. The dialkyl amino acrylonitrile is an intermediate for aminomethylene malononitrile, a valuable intermediate for thiamine.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: June 29, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Manfred Weigele
  • Process for producing dialkyl aminoacrylonitrile
    Patent number: 3965141
    Abstract: A process for producing a dialkyl aminoacrylonitrile by treating dimethylaminopropionitrile with a hydrogen acceptor in the presence of a dehydrogenation catalyst. The dialkylaminoacrylonitrile thus produced is converted to aminomethylene malonitrile, a known intermediate for thiamine.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: June 22, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Manfred Weigele
  • Spirolactone production
    Patent number: 3957826
    Abstract: A novel class of reagents react with primary amine-containing compounds, preferably polypeptides and amino acids, to form highly fluorescent products. This reaction serves as a basis for a rapid and highly sensitive assay method for primary amine-containing compounds.
    Type: Grant
    Filed: May 23, 1975
    Date of Patent: May 18, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Manfred Weigele
  • 6-Substituted 1-phenazinol 5,10-dioxide derivatives
    Patent number: 3937707
    Abstract: 6-Substituted derivatives of 1-phenazinol 5,10-dioxide which possess broad spectrum anti-microbial activity are disclosed.
    Type: Grant
    Filed: July 22, 1974
    Date of Patent: February 10, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Willy Leimgruber, Manfred Weigele