Abstract: Apparatus for actuating a delivery system are disclosed. The apparatus may comprise an adapter. The adapter may comprise an input, a first actuator, and a second actuator. The adapter may be configured to receive a portion of a delivery system. The adapter may be configured to impart translational motion to the delivery system. The adapter may be configured to impart translational motion to a catheter. The adapter may be configured to be actuated by a motorized device or a drill. The adapter may be configured to actuate multiple delivery systems. The adapter may be configured to at least partially compress a portion of an article such as a prosthetic heart valve.

Abstract: Methods and systems for automated language detection for domain names are disclosed. In some embodiments, a method for detecting a language of an Internationalized Domain Name (IDN) comprises receiving, by an I/O interface, a string of characters for the IDN; receiving training data, including a plurality of multi-gram analyses for a set of languages; analyzing, by a processor, the string of characters based on the training data, wherein the analyzing includes extracting a set of multi-grams from the string of characters and comparing the extracted set of multi-grams with the training data; detecting the language of the IDN based on results of the analyzing. In some embodiments, the method further comprises comparing the detected language of the IDN with a user selected language and using the IDN to generate a domain name, if the comparing indicates that the detected language of the IDN is consistent with the user selected language.

Abstract: Embodiments hereof relate to a delivery system for a transcatheter valve prosthesis, the delivery system having an integral centering mechanism to circumferentially center both the delivery system and the valve prosthesis within a vessel at the target implantation site. The centering mechanism may include expandable wings that may be selectively aligned with openings formed through a sidewall of an outer shaft of the delivery system, a coiled wing that may be selectively exposed through an opening formed through a sidewall of an outer shaft of the delivery system, a plurality of elongated filaments extending through a plurality of lumens of an outermost shaft of the delivery system that may be selectively deployed or expanded, an outer shaft that includes at least one pre-formed deflection segment formed thereon, a tool having a deployable lever arm, and/or a plurality of loops deployable via simultaneous longitudinal and rotational movement.

Abstract: Generally, an airline operations computing system accomplishes rule checking in an efficient and useful manner and provides functionality that allows multiple different users to accomplish schedule changes in a manner that minimizes conflicts between different schedulers. In addition, an airline operations computing system includes a common rules engine that is used by multiple different optimizer and decision support systems of the airline operations computing system.

Abstract: Disclosed is an electrolyzer including an electrode including a nanoporous oxide-coated conducting material. Also disclosed is a method of producing a gas through electrolysis by contacting an aqueous solution with an electrode connected to an electrical power source, wherein the electrode includes a nanoporous oxide-coated conducting material.

Abstract: Provided herein are small molecule triazolothienopyrimidine compounds that inhibit urea transport activity of solute transporters, particularly the UT-B transporter. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating refractory edema associated with cardiovascular, renal, and metabolic diseases, disorders, and conditions.

Abstract: A delivery device for implanting a prosthetic heart valve. The device includes an inner shaft assembly, an outer sheath and a connector assembly. The inner shaft assembly defines a guide wire lumen. The outer sheath is slidably received over the inner shaft assembly, and forms an exit port proximate a distal end thereof. The connector assembly establishes a guide wire passageway between the guide wire lumen and the exit port. The connector assembly is configured to permit sliding movement of the outer sheath relative to the inner shaft assembly when deploying the prosthetic heart valve. The connector assembly can include first and second tubes that are slidable relative to one another in facilitating movement of the outer sheath relative to the inner shaft assembly.

Abstract: Methods and systems for automated language detection for domain names are disclosed. In some embodiments, a method for detecting a language of an Internationalized Domain Name (IDN) comprises receiving, by an I/O interface, a string of characters for the IDN; receiving training data, including a plurality of multi-gram analysis for a set of languages; analyzing, by a processor, the string of characters based on the training data, wherein the analyzing includes extracting a set of multi-grams from the string of characters and comparing the extracted set of multi-grams with the training data; detecting the language of the IDN based on results of the analyzing. In some embodiments, the method further comprises comparing the detected language of the IDN with a user selected language and using the IDN to generate a domain name, if the comparing indicates that the detected language of the IDN is consistent with the user selected language.

Abstract: The invention features modular implantable ventricular assist devices configured to be, at least in part, assembled within a patient. The devices generally include a pump assembly and an expandable frame. The frame is configured to engage tissue of a patient when implanted. The pump assembly is configured to be operably coupled to the frame when the frame is implanted and in the expanded configuration.

Abstract: The present disclosure is directed to a metal-containing apparatus including a substrate member constructed of a metal that is highly resistant to pitting corrosion and wear in aggressive media. An exemplary metal-containing apparatus is a plate heat exchanger. The metal includes an oxidation layer on the surface thereof and a thin metal oxide nanoporous film on top of the oxidation layer. The nanoporous film is highly compliant and is comprised of oxygen and aluminum, titanium, silicon, zirconium and combinations thereof.

Abstract: A heart valve therapy system including a delivery device and a stented valve. The delivery device includes an outer sheath, an inner shaft, an optional hub assembly, and a plurality of tethers. In a delivery state, a stent frame of the prosthesis is crimped over the inner shaft and maintained in a compressed condition by the outer sheath. The tethers are connected to the stent frame. In a partial deployment state, the outer sheath is at least partially withdrawn, allowing the stent frame to self-expand. Tension in the tethers prevents the stent frame from rapidly expanding and optionally allowing recapture. Upon completion of the stent frame expansion, the tethers are withdrawn.

Abstract: The present disclosure is directed to a metal-containing apparatus including a substrate member constructed of a metal that is highly resistant to pitting corrosion and wear in aggressive media. An exemplary metal-containing apparatus is a plate heat exchanger. The metal includes an oxidation layer on the surface thereof and a thin metal oxide nanoporous film on top of the oxidation layer. The nanoporous film is highly compliant and is comprised of oxygen and aluminum, titanium, silicon, zirconium and combinations thereof.

Abstract: Provided herein are small molecule triazolothienopyrimidine compounds that inhibit urea transport activity of solute transporters, particularly the UT-B transporter. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating refractory edema associated with cardiovascular, renal, and metabolic diseases, disorders, and conditions.

Abstract: Apparatus for actuating a delivery system are disclosed. The apparatus may comprise an adapter. The adapter may comprise an input, a first actuator, and a second actuator. The adapter may be configured to receive a portion of a delivery system. The adapter may be configured to impart translational motion to the delivery system. The adapter may be configured to impart translational motion to a catheter. The adapter may be configured to be actuated by a motorized device or a drill. The adapter may be configured to actuate multiple delivery systems. The adapter may be configured to at least partially compress a portion of an article such as a prosthetic heart valve.

Abstract: A pump for use in anal irrigation includes a control unit integrated in the pump. The control unit includes a cylindrical housing element and a valve element fitted in the housing. The valve element and the housing element are adapted for rotating with respect to each other between a position allowing the pump to pump air into a balloon, a position allowing the pump to pump air into a reservoir bag and an evacuation position. The control unit is actuated by a handle attached to the rotatable valve element. The handle extends radially out from the rotatable valve element and the cylindrical housing.

Abstract: A system includes a medical device for implanting in a valve of a subject, the implantable medical device having a self-expanding frame; and a holder configured to retain the frame of the implantable medical device in a constricted configuration and to control expansion of the frame. The holder has a controllably constrictable and expandable loop, wherein the loop is disposed about at least a portion of the self-expanding frame such that constriction or expansion of the first loop controls constriction or expansion of the frame.

Abstract: Method and system for routing EPP requests over a network are provided. A routing system includes multiple frontend service interfaces, one or more gateways, a management server, and a backend service platform that provides multiple application services. The frontend service interfaces are addressable using virtual IP addresses (“VIP”) and can be provided by the gateways. The routing system defines a many-to-many mapping between the frontend service interfaces and a set of services provided by the backend service platform. A requestor can send a request over EPP to a targeted service interface to access one or more backend services, by sending the request to a target IP or domain name that corresponds to a VIP associated with the targeted service interface. Using the many-to-many mapping and the VIP of the targeted service interface, the routing system can identify backend services sought by the request and provide the requestor with access to the backend services.

Abstract: An elastic percutaneous elastic introducer sheath is disclosed which can locally expand and reduce to accommodate a transcatheter medical device. The elastic introducer sheath includes a non-circumferentially continuous elastic frame, a liner, and a jacket.