Abstract: A method of estimating whether a statistical model is a false positive, comprising receiving a plurality of predicted outcomes computed by a plurality of statistical models for a historical dataset, computing a correlation matrix for the plurality of predicted outcomes, clustering the plurality of predicted outcomes in a plurality of clusters according to a plurality of clustering schemes based on the correlation matrix, selecting a clustering scheme having a highest quality score among a plurality of clustering schemes, computing, for each of the clusters of the selected clustering scheme, an aggregated predicted outcome aggregating the predicted outcomes clustered in the respective cluster, computing an estimated variance across the clusters, and computing a false positive probability of a selected one of the plurality of statistical models based on the aggregated predicted outcome of the cluster comprising the selected statistical model, the number of clusters, and the estimated variance across all cluster

Abstract: According to exemplary embodiments, a system and method for automated system power supply design is provided. The system and method enables circuit designers to quickly and independently design complicated single or multi rail power supply systems including multiple loads and sequencing requirements. The power solutions offered to designers may include all required power supplies to power up the loads including sequencers and load switches. The power supply design system may be implemented on a standalone processing unit, a distributed computing network, internet based web application, or among various other network applications.

Abstract: A remote-controlled unmanned foldable aircraft comprises at least two motors that allow the aircraft to fly, and at least one support structure for supporting said motors; the support structure is flexible and inflatable such that the support structure can be folded and unfolded between a storage position and an operational position.

Abstract: Systems and methods are disclosed for generating hyperspectral images, which may correspond to a three dimensional image in which two dimensions correspond to a spatial field of view and a third dimension corresponds to a frequency domain absorption spectrum. Disclosed systems and methods include those employing dual optical frequency comb Fourier transform spectroscopy and computational imaging for generation of hyperspectral images. Such a combination advantageously allows for imaging systems to exhibit low size, weight, and power, enabling small or handheld sized imaging devices.

Abstract: The present invention concerns a method for producing a hydrogel comprising the following steps in succession: a first step (i) of providing at least one powder of an anionic polymer (A) and at least one chitosan powder (B) comprising amine functions (—NH2); a second step (ii) consisting in dry mixing at least the powders (A) and (B) from the first step in order to form a mixture of powders; a third step (iii) of suspending the mixture of powders obtained from the second step in an aqueous medium having a pH that can enable the anionic polymer (A) to be dissolved without dissolving the chitosan (B); a fourth step (iv) of adding an acid to the suspension obtained from the third step in order to form the hydrogel; or the third (iii) and fourth (iv) steps are replaced by a mixing fifth step (v), comprising mixing an acidified aqueous medium including at least one compound (C) comprising at least one unit of a hexose or a unit derived from a hexose, and/or at least one phosphate of said compound (C), with said

Abstract: New computational technologies generating systematic investment portfolios by coordinating forecasting algorithms contributed by researchers are provided. Work on challenges is efficiently facilitated by the algorithmic developer's sandbox (“ADS”). Second, the algorithm selection system performs a batch of tests that selects the best developed algorithms, updates the list of open challenges and translates those scientific forecasts into financial predictions. The algorithm controls for the probability of backtest overfitting and selection bias, thus providing for a practical solution to a major flaw in computational research involving multiple testing. Third, the incubation system verifies the reliability of those selected algorithms. Fourth, the portfolio management system uses the selected algorithms to execute investment recommendations. A dynamically optimal portfolio trajectory is determined by a quantum computing solution to combinatorial optimization representation of the capital allocation problem.

Abstract: Described herein are methods and system for generating a hierarchical data structure. A cluster of server computing devices receives a matrix of observations, derives a robust covariance matrix, and divides the matrix of observations into a plurality of computation tasks. Each processor in the cluster generates a first data structure for a distance matrix based upon a corresponding task, the distance matrix comprising a plurality of items, and clusters the items to generate a clustered distance matrix. Each processor generates a second data structure for a linkage matrix using the clustered matrix. Each processor reorganizes rows and columns of the linkage matrix to generate a quasi-diagonal matrix and recursively bisects the quasi-diagonal matrix. Each processor generates a third data structure containing the clusters and assigned weights. Each third data structure is consolidated into a solution vector, which is transmitted to a remote computing device.

Abstract: A method and a system are disclosed for determining a weight allocation in a group comprising a large plurality of items using an optimization oracle, the method comprising obtaining an indication of a plurality of data for each item of a large plurality of items; generating a covariance matrix for the plurality of data; generating a hierarchical tree structure having a plurality of clusters, each cluster having a corresponding item associated therewith, the generating comprising until there is one item associated per cluster of the hierarchical tree structure, recursively formulating an optimization problem to divide a given set of items into two different clusters, translating the formulated optimization problem into an unconstrained binary optimization problem, providing an indication of the unconstrained binary optimization problem to an optimization oracle, receiving an indication of at least one solution from the optimization oracle, assigning a cluster to each item of the given set of items using the a

Abstract: The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.

Abstract: A cluster of server computing devices receives a matrix of observations and divides the matrix into a plurality of input data sets. Each processor in the cluster generates a first data structure for a distance matrix based upon a corresponding input data set, the distance matrix comprising a plurality of items, and clusters the items to generate a clustered distance matrix. Each processor generates a second data structure for a linkage matrix using the clustered matrix. Each processor analyzes the linkage matrix to determine a number of items per cluster and analyzes the linkage matrix to assign a weight to each cluster based upon a distance of the cluster to other clusters and a size of the cluster. Each processor generates a third data structure containing the clusters and assigned weights. Each third data structure is consolidated into a hierarchical data structure, which is transmitted to a remote computing device.

Abstract: The invention relates to a carbon-free electrocatalyst for fuel cells, containing an electrically conductive substrate and a catalytically active species, wherein the conductive substrate is an inorganic, multi-component substrate material of the composition 0X1-0X2, in which 0X1 means an electrically non-conductive inorganic oxide having a specific surface area (BET) in the range of 50 to 400 mVg and 0X2 means a conductive oxide. The non-conductive inorganic oxide 0X1 is coated with the conductive oxide 0X2. The multi-component substrate preferably has a core/shell structure. The multi-component substrate material 0X1-0X2 has an electrical conductivity in the range>0.01 S/cm and is coated with catalytically active particles containing noble metal. The electrocatalysts produced therewith are used in electrochemical devices such as PEM fuel cells and exhibit high corrosion stability.

Abstract: According to exemplary embodiments, a system and method for automated system power supply design is provided. The system and method enables circuit designers to quickly and independently design complicated single or multi rail power supply systems including multiple loads and sequencing requirements. The power solutions offered to designers may include all required power supplies to power up the loads including sequencers and load switches. The power supply design system may be implemented on a standalone processing unit, a distributed computing network, internet based web application, or among various other network applications.

Abstract: Vaccine compositions that comprise at least one antigen based on the dengue virus (DV) capsid protein and the oligonucleotide identified as SEQ ID NO 1. The vaccine composition that comprises a fusion protein formed by the DV2 capsid and domain III of the envelope protein of the same serotype, together with the oligonucleotide identified as SEQ ID NO 1, gives rise to higher levels of cellular immune response and protection in mice as compared with that produced by formulations of the same antigen together with oligonucleotides with potential adjuvant capacity which were reported previously. The efficacy of the compositions that comprise the SEQ ID NO 1 oligonucleotide has been demonstrated in non-human primates. These compositions may be monovalent, bivalent or tetravalent and are combined in different immunization regimes with a view to inducing a functional immune response to the four viral serotypes.

Abstract: Vaccine compositions that comprise at least one antigen based on the dengue virus (DV) capsid protein and the oligonucleotide identified as SEQ ID NO 1. The vaccine composition that comprises a fusion protein formed by the DV2 capsid and domain III of the envelope protein of the same serotype, together with the oligonucleotide identified as SEQ ID NO 1, gives rise to higher levels of cellular immune response and protection in mice as compared with that produced by formulations of the same antigen together with oligonucleotides with potential adjuvant capacity which were reported previously. The efficacy of the compositions that comprise the SEQ ID NO 1 oligonucleotide has been demonstrated in non-human primates. These compositions may be monovalent, bivalent or tetravalent and are combined in different immunization regimes with a view to inducing a functional immune response to the four viral serotypes.

Abstract: The present invention is directed to catalyst particles comprising a layered core-shell-shell structure and to a method of their manufacture. The catalyst particles have the general formula BM/IL/PM in which BM is a base metal core (selected from Co, Ni or Cu), PM is a precious metal outer shell (selected from Pt, Ir or Pd) and IL is an intermediate layer comprising a base metal/precious metal alloy with a concentration gradient of base metal to the outside PM layer. The particles of the present invention comprise a core-shell-shell structure and a substantially continuous precious metal shell layer. They find use in various catalytic applications, for example in gas-phase catalysis, in electrocatalysts for fuel cells, in catalytic converters for automobiles and in electronic or medical applications.

Abstract: New computational technologies generating systematic investment portfolios by coordinating forecasting algorithms contributed by researchers are provided. Work on challenges is efficiently facilitated by the algorithmic developer's sandbox (“ADS”). Second, the algorithm selection system performs a batch of tests that selects the best developed algorithms, updates the list of open challenges and translates those scientific forecasts into financial predictions. The algorithm controls for the probability of backtest overfitting and selection bias, thus providing for a practical solution to a major flaw in computational research involving multiple testing. Third, the incubation system verifies the reliability of those selected algorithms. Fourth, the portfolio management system uses the selected algorithms to execute investment recommendations. A dynamically optimal portfolio trajectory is determined by a quantum computing solution to combinatorial optimization representation of the capital allocation problem.

Abstract: The invention relates to a carbon-free electrocatalyst for fuel cells, containing an electrically conductive substrate and a catalytically active species, wherein the conductive substrate is an inorganic, multi-component substrate material of the composition 0X1-0X2, in which 0X1 means an electrically non-conductive inorganic oxide having a specific surface area (BET) in the range of 50 to 400 mVg and 0X2 means a conductive oxide. The non-conductive inorganic oxide 0X1 is coated with the conductive oxide 0X2. The multi-component substrate preferably has a core/shell structure. The multi-component substrate material 0X1-0X2 has an electrical conductivity in the range>0.01 S/cm and is coated with catalytically active particles containing noble metal. The electrocatalysts produced therewith are used in electrochemical devices such as PEM fuel cells and exhibit high corrosion stability.

Abstract: The present invention is directed to catalyst particles comprising a layered core-shell-shell structure and to a method of their manufacture. The catalyst particles have the general formula BM/IL/PM in which BM is a base metal core (selected from Co, Ni or Cu), PM is a precious metal outer shell (selected from Pt, Ir or Pd) and IL is an intermediate layer comprising a base metal/precious metal alloy with a concentration gradient of base metal to the outside PM layer. The particles of the present invention comprise a core-shell-shell structure and a substantially continuous precious metal shell layer. They find use in various catalytic applications, for example in gas-phase catalysis, in electrocatalysts for fuel cells, in catalytic converters for automobiles and in electronic or medical applications.

Abstract: The invention discloses core/shell, type catalyst particles comprising a Mcore/Mshell structure with Mcore=inner particle core and Mshell=outer particle shell, wherein the medium diameter of the catalyst particle (dcore+shell) is in the range of 20 to 100 nm, preferably in the range of 20 to 50 nm. The thickness of the outer shell (tshell) is about 5 to 20% of the diameter of the inner particle core of said catalyst particle, preferably comprising at least 3 atomic layers. The core/shell type catalyst particles, particularly the particles comprising a Pt˜based shell reveal a high specific activity. The catalyst particles are preferably supported on suitable support materials such as carbon black and are used as electrocatalysts for fuel cells.

Abstract: 99mTc-labeled triphenylphosphonium contrasting agents that target the mitochondria and are useful for early detection of breast tumors using scintimammographic imaging. 99mTc-Mito10-MAG3 possesses advantageous radiopharmaceutical properties. The uptake in the myocardium is reduced by one to two orders of magnitude compared to 99mTc-MIBI. 99mTc-Mito10-MAG3 exhibits fast blood clearance, with a blood half-life of less than 2 minutes in rats. A diminished myocardial uptake combined with a prompt reduction of cardiovascular blood pool signal to facilitate improved signal-to-background ratios.