Abstract: Methods and systems for providing quick capture for learning and assessment are provided herein. An example method includes providing a plurality of graphical user interfaces (GUIs), the plurality of graphical user interfaces for capturing unique categories of evidence of student learning, the evidence of student learning including a plurality of media types, receiving evidence of student learning including both media and narrative content from a teacher using the plurality of graphical user interfaces, synchronizing the evidence of student learning with one or more student accounts, and assigning at least a portion of the evidence of student learning to a student portfolio.

Abstract: Methods and systems for providing smart guides for teachers, students, parents, and administrators are provided herein. In one embodiment, a teacher guide includes a web-based interface that receives information transmitted by a teacher electronic, the information including at least one of a course curriculum, a lesson plan, a learning objective, an educational activity associated with a specific learning objective, and evidence of learning by a student. The guide also receives an assessment of the student progress on attaining the learning objective, or a suggestion, based on the assessment of a student progress, to the teacher of an individualized learning resource from a resource database that could assist the student in attaining the learning objective. Communication is also provided, enabling the teacher to provide at least one of the student and the parent with at least one of an individualized feedback and a learning resource.

Abstract: A conjugate comprises: (a) a mitochondrial membrane-permeant peptide; (b) an active agent or compound of interest such as a detectable group or mitochondrial protein or peptide; and (c) a mitochondrial targeting sequence linking said mitochondrial membrane-permeant peptide and said active mitochondrial protein or peptide. The targeting sequence is one which is cleaved within the mitochondrial matrix, and not cleaved within the cellular cytoplasm, of a target cell into which said compound is delivered. Methods of use of such compounds are also described.

Abstract: Compositions and methods for screening for a disease or a disorder associated with a deficiency in frataxin in a subject using biomarkers for diseases or disorders associated with a deficiency in frataxin are disclosed. The compositions and methods include determining the acetylation status of mito-chondrial proteins. Also disclosed are methods of detecting progression of a disease or a disorder associated with a deficiency in frataxin in a subject and methods of monitoring effectiveness of a therapy for diseases or disorders associated with a deficiency in frataxin.

Abstract: An orthodontic appliance is automatically designed and manufactured from digital lower jaw and tooth shape data of a patient. A computer calculates the post-treatment positions of the teeth and produces three-dimensional images of the teeth, individually and in their calculated positions. The appliance is automatically designed according to the final design, which also can be interactively modified and approved by the orthodontist, with the computer recalculating the effects on the treatment as a result of the doctor's changes. Brackets are fabricated as an integrated set, either by cutting slots therein or by building the brackets in layers by, for example, stereo lithography. Three-dimensional custom jigs are automatically made to exactly position the brackets on a patient's teeth.

Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.

Abstract: The present disclosure relates generally to fusion proteins including gigaxonin coupled to a cell penetrant peptide. These fusion proteins can be used to treat GAN in a subject in need thereof. Administration of the fusion proteins allows for control of at least one of Galectin-1 (GAL-1) levels and phosphorylated vimentin protein levels, thereby mediating aggregation of vimentin and the formation of vimentin-free zones in cells.

Abstract: Isolated transduced cells exhibiting FRDA characteristics in an inducible fashion are disclosed. Isolated transduced cells comprise an expression vector having a nucleic acid sequence encoding an shRNA for frataxin protein knockdown and a heterologous expression control sequence. Additionally, methods of screening for a candidate therapeutic agent for treating Friedreich's Ataxia using isolated transduced cells are disclosed. Further, a recombinant nucleic acid construct for frataxin knockdown is disclosed that comprises a nucleic acid encoding an shRNA operably linked to a heterologous expression control sequence and expressing an shRNA molecule in a dose-responsive fashion.

Abstract: Tissue expanders and methods of use. In some embodiments the tissue expanders are adapted to reduce wear on one or more components.

Abstract: Tissue expanders and their methods of use.

Abstract: Tissue expanders and their methods of use.

Abstract: A conjugate comprises: (a) a mitochondrial membrane-permeant peptide; (b) an active agent or compound of interest such as a detectable group or mitochondrial protein or peptide; and (c) a mitochondrial targeting sequence linking said mitochondrial membrane-permeant peptide and said active mitochondrial protein or peptide. The targeting sequence is one which is cleaved within the mitochondrial matrix, and not cleaved within the cellular cytoplasm, of a target cell into which said compound is delivered. Methods of use of such compounds are also described.

Abstract: A system (10) and method by which an orthodontic appliance (25) is automatically designed and manufactured from digital lower jaw and tooth shape data of a patient provides for the scanning of the mouth of a patient (12), preferably from a model (20) of the patient's mouth, to produce a three-dimensional digitized model (26) of the shapes of the patient's teeth and their positions in the patient's mouth. Then a computer (30) calculates the post-treatment positions of the teeth and produces three-dimensional images of the teeth, individually and in their calculated positions.

Abstract: Embodiments provide systems and methods for maintaining immutable data in an archiving system using random access memory. To ensure data is immutable, novel pointers are maintained. For example, a modular drive bay maintains a pointer to a memory address in the removable drive memory cannot write data to a memory block that precedes the pointer. Data may only be stored after the pointer in the removable drive. As such, once data is written to the removable drive, the data cannot be overwritten although the removable drive employs random access memory.

Abstract: Tissue expanders and their methods of use.

Abstract: Embodiments provide unique and novel systems and methods for deleting data on removable drives. In embodiments, the removable drives store data that may be erased such that the data is considered destroyed but that allows the removable drive to be reused. The archiving system can determine which data should be erased. Then, the data is digitally shredded on sector boundaries of the removable drives such that the reclaimed memory cannot be read to decipher the erased data. In alternative embodiments, data is written across sector boundaries such that two or more files may occupy a single sector. A journal area allows for copying the data in a sector with two or more files, digitally shredding the sectors in the removable drive, and rewriting the data that was not to be digitally shredded to the original location of the data.

Abstract: Tissue expanders and their methods of use.

Abstract: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.

Abstract: Embodiments provide systems and methods for maintaining immutable data in an archiving system using random access memory. To ensure data is immutable, novel pointers are maintained in the hardware/firmware of the drive ports and on the removable disk drives. For example, a hardware/firmware in a modular drive bay maintains a pointer to a memory address in the removable disk drive memory that cannot write to a memory block that precedes the pointer. Data may only be stored after the pointer in the removable disk drive. As such, once data is written to the removable disk drive, the data cannot be overwritten although the removable disk drive employs random access memory.

Abstract: A conjugate comprises: (a) a mitochondrial membrane-permeant peptide; (b) an active agent or compound of interest such as a detectable group or mitochondrial protein or peptide; and (c) a mitochondrial targeting sequence linking said mitochondrial membrane-permeant peptide and said active mitochondrial protein or peptide. The targeting sequence is one which is cleaved within the mitochondrial matrix, and not cleaved within the cellular cytoplasm, of a target cell into which said compound is delivered. Methods of use of such compounds are also described.