Abstract: A stoppered vial containing a medicament to be mixed with a diluent is enclosed within a flexible I.V. fluid container. Mixing of the medicament in the stoppered vial with a diluent also contained within the flexible I.V. fluid container is accomplished by first, unstoppering the vial by manipulation of the flexible sides of the container; then second, causing the fluid to intermix with the medicament in the vial by compressing that portion of the flexible container holding the diluent.

Abstract: A system for separately storing and sterilely mixing a diluent and a medicament within a dual chambered flexible container for eventual use in an I.V. administration system. Mixing of the contents of the two chambers is accomplished by compressing the sides of the flexible container thus causing a weakened portion in the partition between the two chambers in the flexible container to rupture, thereby providing fluid communication between the chambers and effecting intermixing of the contents thereof.

Abstract: A container mixing system wherein a medicament is placed in a container mounted externally of a container with a diluent. Mixing of the medicament in one container with the diluent in the other is accomplished by attaching an additive assembly with a piercing element to an additive port of the diluent container to pierce a diaphragm in the additive port and a diaphragm or stopper in the additive container. In one embodiment, the additive assembly includes a bellows portion which will permit movement of the piercing element through the additive assembly stopper and the port diaphragm while maintaining a sterile medicament in a glass vial.

Abstract: A compartmented and collapsible container system for sterile components which has a separate compartment for each component with a secondary container compartment within a larger container compartment, yet will permit the intermixing of the components upon the selective delamination of a frangible seal which separates the compartments. The compartmented container is specifically constructed for use with two components which are normally incompatible when mixed. The container herein described permits the two incompatible components to be sterilized in a disposable, flexible container. At the time of usage, the two materials can be readily intermixed in the same container and administered therefrom, such as with the usual intravenous administration equipment.

Abstract: A container mixing system wherein a medicament is placed in a container mounted externally of a container with a diluent. Mixing of the medicament in one container with the diluent in the other is accomplished by moving a piston member with a piercing element in the direction of the diluent container to pierce a diaphragm or stopper in the medicament container. In one embodiment, the medicament container is sealed by means of a flange to the diluent container wall and the piercing element will pierce a diaphragm and the container wall with the piercing member also serving as an injection site.

Abstract: A port system for a blow molded intravenous solution container in which microbial contamination is prevented upon administration of the solution. The port system includes an integrally formed tube projecting outwardly from the container with a pierceable diaphragm positioned over the entry portion of the tube. Preferably, with respect to the tube entry portion, the diaphragm is concave, and may be made thinner in the center to facilitate proper placement of a piercing pin. In one embodiment, the port tube is inwardly flared adjacent the diaphragm so that as the piercing element is pushed through the diaphragm, the remnants of the pierced diaphragm can be pressed into the flared portion of the tube.

Abstract: A dual compartmented container containing a medicament in one compartment and a diluent in the other with an actuating piercing element operable from outside the container. Mixing of the medicament in one compartment with the diluent in the other is accomplished by moving the piercing element inwardly into the container to pierce a primary diaphragm which seals one of the compartments to outside atmosphere as well as a secondary diaphragm which seals the compartments from each other. The piercing element is constructed and arranged to afford fluid communication between the compartments after it pierces both diaphragms. Intermixing of the contents of the container can thereby be made internally thereof.

Abstract: A container for liquids, preferably sterile liquids comprises a hollow body constructed of plastic material having a plurality of tubular ports integrally formed and extending therefrom. Each port has a quantity of plastic material integrally formed as a diaphragm within the port so as to seal the container. In a preferred embodiment, at least one of the ports has a resealable septum sealed within it. The diaphragm is positioned between the septum and the liquid within the container so as to prevent deterioration of the resealable septum caused by exposure to the liquid. Both the resealable septum and the diaphragm are constructed of a material which is penetrable by a hypodermic needle for use in administering sterile solutions. A removable twist cap is integrally formed about and seals the end of each tubular port.

Abstract: A port structure is provided for a container such as a flexible bag for I.V. fluids which will permit the piercing by a piercing pin in a leak resistant manner. The port structure is fabricated with the usual piercing diaphragm positioned in the innermost portion of the tubular port. Unlike the usual construction of port structures of this type, the inner tubular member containing the pierceable diaphragm is not connected to the remaining portions of the port structure at the outermost regions thereof or adjacent the flange or connecting portions, but instead joins the tubular member at an intermediary position so as to create a standing port for receiving the piercing pin.

Abstract: A container for liquids, preferably sterile liquids comprises a hollow body constructed of plastic material having a plurality of tubular ports integrally formed and extending therefrom. Each port has a quantity of plastic material integrally formed as a diaphragm within the port so as to seal the container. In a preferred embodiment, at least one of the ports has a resealable septum sealed within it. The diaphragm is positioned between the septum and the liquid within the container so as to prevent deterioration of the resealable septum caused by exposure to the liquid. Both the resealable septum and the diaphragm are constructed of a material which is penetrable by a hypodermic needle for use in administering sterile solutions.

Abstract: An improved apparatus for aseptically connecting medical liquid containers to a length of flexible tubing comprises a port on the container, a pierceable diaphragm within the port, and a hollow tubular piercing pin connected to the length of flexible tubing adapted for penetrating the pierceable diaphragm. An alignment tray having a bag port cavity integrally formed therein is adapted for receiving and fixedly positioning the bag port and the bag. A guide mechanism integrally formed along the length of the tray is constructed to align the piercing pin and allow it to be slidably joined to the bag port without touch contamination of the port or the pin.

Abstract: A connecting device for medical liquid administration sets, particularly for use in continuous ambulatory peritoneal dialysis comprises a tubular port extending from a medical liquid container. The tubular port has a pierceable diaphragm positioned within and sealing the same. A hollow tubular piercing pin having a sharpened tip is used for penetrating the pierceable diaphragm. A length of flexible tubing extends from the piercing pin and is connected to a catheter positioned in the peritoneum of the patient once the piercing pin and port are connected. A locking mechanism is utilized for selectively retaining the piercing pin within the tubular port following insertion, and for asepticizing the connection.

Abstract: An improved in-line sleeve valve comprises a modular tubular port having a stationary plug concentrically supported therein and a reciprocating tubular sleeve arranged for sealing against the stationary plug. A resilient, flexible flange connects the tubular sleeve and the tubular port. The flange is sufficiently elastic to allow easy manual displacement of the sleeve from the tubular stationary plug in order to allow the flow of liquid, but is biased in a first direction so as to return the tubular sleeve to a position abutting the stationary plug upon release thereof.

Abstract: A hanger construction for a collapsible container for medical fluids which is fabricated in such a manner that it is scrapless and positioned within the confines of the container. The hanger is formed with tear and hinge lines so that one or more tab portions are easily torn from and displaced from the bag surface to provide a hanger hole. Hinge lines are positioned to afford a biasing of the displaced portions outwardly from the bag surface so that they will not "reclose" in the hanger hole. A tear point is utilized for ease in initiating the tearing away of the tab portions. The resulting hanger hole is of a geometric configuration in that it will accommodate most any support structure and the displaced portions are of a configuration in that they will not "hang up" or "dig" into the support structure. These features permit ease of fabrication and placement of the bag over a support device.

Abstract: An improved connecting device for medical liquid containers comprises an elongated tubular member having a lumen extending therethrough. Pivotable finger tabs are hingedly attached to and extend from the elongate tubular member, adapted for engagement with the fingers so as to facilitate application of the device to the liquid container. The finger tabs are pivotable in order to allow folding of the tabs against the elongate tubular member in a first position or selective extension of the tabs to a position perpendicular from the tubular member prior to use. The tabs are thereby compactly stored so that when a bag, such as a peritoneal dialysis or irrigation bag must be carried by the patient, the tabs are not in an extended position which would cause discomfort to the patient.

Abstract: A closure is provided for a container such as a flexible bag for I.V. liquids which is easily removed therefrom with a minimum amount of force. The easily-removable cap structure affords a sterile closure system, yet at the same time is susceptible of different geometric configurations which concentrate pulling forces in a confined area and in conjunction with a pre-weakened tear line so that a force not exceeding more than about 12 pounds will initiate a tearing away of the cap structure so as to expose the port and the contents of the container.