Abstract: The various embodiments disclosed herein relate to bone fixation devices, including intramedullary fixation or fusion devices. The various devices disclosed include an intermedullary device having a proximal member and a distal member that is articulable in relation to the proximal member. The proximal and distal members have ends that are movably coupled to form a joint that can be actuated to reduce a fracture and realign the bone after insertion of the device into the bone.

Abstract: The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy.

Abstract: Disclosed herein is a computer-implemented method comprising aggregating PFAS remediation evaluation data for a plurality of remediation options and for a plurality of predefined criteria; graphically displaying the user modifiable chart comprising the plurality of graphical representations of the aggregated PFAS remediation evaluation data, wherein: each graphical representation depicts data points visually plotted with weights, the plurality of graphical representations for the plurality of predefined criteria are visually ordered according to a rank of the plurality of predefined criteria, and the weights are based on the rank of the plurality of predefined criteria; detecting a first user input modifying the rank of at least one predefined criterion; in accordance with the first user input, automatically updating the weights of the data points; and displaying an updated user modifiable chart comprising the plurality of graphical representations of the aggregated PFAS remediation evaluation data.

Abstract: An analytics module included in a processing system receives performance feedback related to a broadcast media item. The performance feedback includes metadata associated with the feedback. Based on the metadata, the analytics module distinguishes between first performance feedback provided by automated programs and second performance feedback provided by valid users. The second performance feedback is transmitted to a media proposal server, but the first performance feedback is not. The media proposal server determines, based on the second performance feedback, that the broadcast media item is to be replaced by a replacement broadcast media item.

Abstract: The present disclosure pertains to a system configured to protect flows in piping systems using minimal spare components. Some embodiments may provide: a first piping subsystem configured to receive a portion of the input flow; a second piping subsystem configured to receive the portion of the input flow by substituting for the first subsystem; a test subsystem configured to detect whether each of the first and second subsystems is able to vent when at least one, in the each subsystem, of a respective pressure and a respective pressure rate satisfies first and second criteria, respectively; and first and second pilots configured to detect a maximum pressure and a maximum pressure rate, respectively, of the portion of the first and second subsystems.

Abstract: A meditation system comprising a meditation surface including a contactless bio-sensor and a processor to analyze data from the contactless bio-sensor, to determine meditation results including a user's respiration, heart rate, and meditation quality, the processor further to calculate a recommendation to the user based on the meditation results. The system further comprising a user interface to display the meditation results and the recommendation.

Abstract: Various bone fixation device embodiments include both a fixation device (such as a screw) and a detachable driver device, with the fixation device having an elongate uncannulated fixation shaft, a sharp distal tip, and a proximal head having a first coupling structure and a proximal flat surface, and the detachable driver device having an elongate driver shaft and a distal head having a second coupling structure and a distal flat surface. Further implementations include a combination device comprising both a detachable driver device and a fixation device, along with related systems and methods. In addition, a stabilization device is provided that can be coupled to a detachable driver device and an attachment device to help maintain the coupling of the driver device and the attachment device and help to maintain the coupling thereof during a procedure.

Abstract: A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a prion protein (PRNP) gene, as well as methods of inhibiting expression of a PRNP gene and methods of treating subjects having a PRNP-associated disease or disorder, e.g., Prion diseases, using such dsRNAi agents and compositions.

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the Invention include compounds having the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R1c, R1d, R1e, R1f, R1g, R2, X, L and A are as defined herein.

Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.

Abstract: A solar tracking mounting system is provided. The tracking system has an anchor comprising a pile and a riser bracket fastened to the top thereof, wherein the riser bracket is configured to provide adjustable mounting points, a chord assembly coupled to with the riser brackets, wherein the chord assembly is configured to pivotability tilt, a kicker connected to the anchor assembly, wherein the kicker is configured to connect the chord assembly to the pile, a vertical actuator connected to the kicker and the chord assembly, wherein the vertical actuator is a rack and pinion linear actuator configured to amplify a torque received from a motor and pivotably tilt to the chord assembly to a desired angle while tracking a direction of a light source, and a driveshaft connected to the motor and the vertical actuator. A jack screw may also be provided therein for actuation.

Abstract: An exposed secondary showerhead system configured to be supported by a conventional shower enclosure. The illustrative showerhead system includes an overhead conduit fluidly coupled to a conventional shower inlet pipe and to at least one showerhead.

Abstract: Mobile management method, system and client. Method includes receiving a DNS query for a host name from an application on client; retrieving reputation data associated with host name from a local cache on client; and determining a policy based on host name and the reputation data. Based on determined policy for the host name, blocking attempted network flows to a host corresponding to host name to produce blocked attempted network flows. Method also includes sending attempted network flow metadata related to the blocked attempted network flows to a collector on client; transmitting the attempted network flow metadata from the collector to a VPN server pool via a VPN tunnel; and producing an anomaly report from the transmitted attempted network flow metadata. The anomaly report includes at least one of anomalies, cohorts, trends, location boundaries, detected network security issues, detected compromised clients and/or optimized network usage.

Abstract: A unified authentication system for decentralized identity platforms is disclosed. In various embodiments, a request comprising one or more identity claims and a digital address is received. The digital address is used to verify, via a verification node associated with a digital address provider, the one or more identity claims. Access to a service is provided, in response to the request, based at least in part on a response from the verification node indicating the one or more identity claims have been verified. The verification node is configured to obtain consent, in real time, from a user with which the digital address is associated, prior to providing said response indicating the one or more identity claims have been verified.

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30).

Abstract: This invention relates to novel whitening agents for cellulosic substrates. The whitening agents are comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. The whitening agents are further characterized by having a dispersion component value of the Hansen Solubility Parameter of less than or equal to about 17 MPa0.5. This invention also relates to laundry care compositions including but not limited to liquid and/or powder laundry detergent formulations and rinse added fabric softening (RAFS) compositions that comprise such whitening agents.

Abstract: An electrically insulated block-on-rotating-ring test unit and method, to evaluate the effects of electrical potential on material pairs and fluids under mechanical load and in sliding contact. The fluids may comprise lubricants and oils utilized in electrical vehicles.