Abstract: Multi-filament microcables are used in place of the traditional monofilament wires as the constituent elements of a woven or braided band. This enhances the function and manufacturability of such bands for various applications, such as orthopaedic applications including sternotomy closures.

Abstract: Gear devices and methods for operating gear devices are provided. In one example, a gear device is provided that comprises structures designed to attenuate targeted vibrations occurring during rotation of the gear device. The structures includes radially aligned struts extending between an inner carrier and an outer carrier, a plurality of openings arranged between the struts, and/or resonators extending between sequential struts.

Abstract: The present disclosure provides high-load tablet formulations of AG10 or a pharmaceutically acceptable salt thereof. In some aspects, provided herein are table formulations of AG10 or a pharmaceutically acceptable salt thereof that include at least 40% or more AG10 by weight and at least one pharmaceutical excipient selected from one or more fillers, one or more binders, one or more disintegrants, and one or more lubricants.

Abstract: A capsular prosthesis is disclosed that is implanted to support posterior chamber placement of IOLs. The capsular prosthesis can be implanted to replace the capsule in situations where the patient's natural capsule has been rendered incapable of providing the structural support necessary to maintain proper centration of an IOL implanted therein. The prosthesis is surgically implanted into the eye by inserting the prosthesis into the eye through a primary incision. The prosthesis is secured to the sclera of the eye with at least two transscleral sutures to establish at least three points of contact between the sclera and the at least three apertures of the prosthesis. The at least two transscleral sutures support the sheet within a desired plane located within the posterior chamber, the plane containing a predetermined surgical axis passing through the center aperture. The IOL is inserted through the primary incision and optically captured on the prosthesis.

Abstract: The present disclosure provides high-load tablet formulations of AG10 or a pharmaceutically acceptable salt thereof. In some aspects, provided herein are table formulations of AG10 or a pharmaceutically acceptable salt thereof that include at least 40% or more AG10 by weight and at least one pharmaceutical excipient selected from one or more fillers, one or more binders, one or more disintegrants, and one or more lubricants.

Abstract: An automated laboratory system includes a vertical shelving system including a frame and at least one shelf movably mounted to the frame such that the at least one shelf is movable relative to the frame between a docked position and an undocked position, the at least one shelf being configured to carry at least one instrument. The system also includes a robotic device proximate the vertical shelving system and being configured to access the at least one instrument carried by the at least one shelf.

Abstract: Methods and systems are provided for a turbine integrally formed with a cylinder head. In one example, a system includes a cylinder head and a turbine shaped from a single, continuous piece of metal.

Abstract: Gear devices and methods for operating gear devices are provided. In one example, a gear device is provided that comprises structures designed to attenuate targeted vibrations occurring during rotation of the gear device. The structures includes radially aligned struts extending between an inner carrier and an outer carrier, a plurality of openings arranged between the struts, and/or resonators extending between sequential struts.

Abstract: A process for producing a solid dispersion of a material by spraying the material onto a fluidized cloud of carrier particles in a fluid bed. The fluidized cloud of carrier particles is formed by adding a solid or liquid carrier to a fluid bed. The material to be sprayed is in a liquid or gas form. The process is especially applicable to the formation of amorphous solid powder pharmaceutical ingredients.

Abstract: CD47+ disease cells such as cancer cells are treated using a combination of CD47 blocking agent and a CD38 antibody such as daratumumab. The anti-cancer effect of SIRP?Fc is enhanced in the presence of daratumumab. Specific combinations include SIRP?Fc forms that comprise an Fc that is either IgG1 or IgG4 isotype. These combinations are useful particularly to treat blood cancers including lymphomas, leukemias and myelomas.

Abstract: CD47+ disease cells such as cancer cells are treated using a combination of CD47 blocking agent and an EGFR antibody such as cetuximab. The anti-cancer effect of cetuximab is enhanced in the presence of SIRP?Fc. Specific combinations include SIRP?Fc forms that comprise an Fc that is either IgGl or preferably IgG4 isotype. These combinations are useful particularly to treat solid tumours and blood cancers including lymphomas, leukemias and myelomas.

Abstract: Methods and systems are provided for a turbine integrally formed with a cylinder head. In one example, a system includes a cylinder head and a turbine shaped from a single, continuous piece of metal.

Abstract: A methodology for operating an authoritative DNS server includes receiving a DNS query from a DNS client, in response to the DNS query, traversing a label tree stored in the authoritative DNS server to find a resource record that matches the DNS query, while traversing the label tree, encountering a LINK record in the label tree that is configured to redirect the traversing to a different branch of the label tree, and in response to the LINK record, redirecting the traversing to the different branch of the label tree, wherein the LINK record is a resource record type that is hidden from DNS clients and is configured to redirect for an owner of the record type and subordinates thereof.

Abstract: CD47+ disease cells, such as various cancers, are treated using a combination of CD47 blockade with T cell checkpoint inhibition. Preferred embodiments use SIRP?Fc in combination with a PD-1 pathway inhibitor such as nivolumab and/or a CTLA-4 inhibitor such as ipilimumab.

Abstract: A tubular member (1) with a relative rough (1.5-10 ?m) inner surface (5) coated solid lubricating film (10) which is transformed into a substantially viscous rubbery viscoelasto-plastic phase at temperatures in a range between 50° C. and 110° C. is expanded by moving an expansion member (24) with a relatively smooth outer surface (roughness<1.5 ?m) therethrough, such that during expansion a viscous viscoelastoplastic substantially rubbery lubricating film (44) is generated between the tubular member (1) and the expansion mandrel (24), which film remains bonded to the rough inner surface (5) of the expanded tubular (1), but does not stick to the relatively hot and smooth expansion member (24).

Abstract: Systems and methods for automatic repair, replacement, and/or configuration of various network devices within a communications network are disclosed. The system may receive indication of a failed network device and automatically perform diagnostic on the network device to determine any problems associated with the hardware and/or software components within the network device. Subsequently one or more repair, replacement, and/or configuration procedures may be automatically initiated in an attempt to resolve the problems and restore the failed network device.

Abstract: A card includes a substrate having a first surface and a second surface opposite the first surface. The first surface has a first surface area. The card also includes an image area on the first surface. The image area has a second surface area less than the first surface area. The cars further includes a contrast region between the image area and an edge of the substrate. The contrast region is a solid border surrounding the image area. The card additionally includes a plurality of markings extending from the contrast region into the image area. Each marking of the plurality of markings arranged in a pattern such that the markings of the plurality of markings are separated from one another by a portion of the image area.