Abstract: A method and composition for preserving or enhancing the beneficial effects of interlude-2 (IL-2) while simultaneously mitigating the adverse effects of IL-2 on a subject is disclosed. The method involves administering an amount of a leukotriene B4 (LTB4) antagonist, preferably a LTB4 receptor antagonistic, to a subject exhibiting adverse pharmacological effects due to exogenous IL-2, where the amount administered to the subject is sufficient to decrease the IL-2 induces adverse effects. Also disclosed is an article of manufacturing comprising a composition of the leukotriene B4 antagonist in combination with labeling instructions for treatment. Also disclosed is a method for preparing a pharmaceutical composition. Generally the LTB4 antagonist will reduce the IL-2-induced adverse effects while preserving or enhancing the anti tumor, antiviral, or immunostimulatory effects of IL-2, thereby improving the therapeutic index of IL-2.

Abstract: The present invention relates to methods of protecting against injury to hair follicles in a mammal by administering an effective amount of butyric acid or a biologically active butyric acid derivative. In particular, this invention relates to the use of cell differentiation-inducing butyric acid derivatives to protect against hair loss in cancer patients undergoing chemotherapy and/or radiation therapy.

Abstract: A battery-powered tire pressure monitor and inflation system which is mounted entirely on or within a vehicle wheel, preferably on the inner surface of a wheel cover. The entire system rotates concurrently with the vehicle wheel, thereby eliminating the need for any interconnection between non-rotating and rotating components of the vehicle. The preferred system also incorporates a centrifugal intake valve apparatus, which remains closed until the vehicle wheel exceeds a minimum rotational rate. The centrifugal intake valve closure apparatus thereby prevents fluids or particles from being drawn into the compressor.

Abstract: A non-volatile, in-system programmable integrated-circuit switch has horizontal conductive lines and vertical conductive lines. A programmable interconnect cell including a floating gate transistor is provided at each intersection of a horizontal line and a vertical line. Each line is connected to a pin through a programmable I/O cell which includes a floating gate transistor. Each I/O cell can be programmed to configure the corresponding pin as an input pin or as an inverting or non-inverting output pin. The I/O cell can also be programmed to tri-state the pin or to fix the pin at a high or low voltage level. Each input pin can be connected to more than one output pins. A TTL-to-CMOS translator in each I/O cell is provided in the output section of the cell to reduce the translator output load and make the load, and hence the speed and power consumption of the switch, less dependent on the switch programming.