Abstract: Methods, kits, and compositions are provided herein that can be used to treat ovarian cancer using an anti-CD47 antibody. The anti-CD47 antibody can be used alone or in combination with one or more additional agent such as chemotherapy.

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: This invention relates to a lubricating composition comprising or resulting from the admixing of: base oil, detergent, and one or more metal alkanoates having a quaternary carbon atom at the 2 position, the 2? position, or both the 2 and 2? positions, where the lubricating composition preferably has an adhesive wear of 100 hours or more, a foam volume of 70 ml or less at 24° C., and 50 ml or less at 93.5° C., and, optionally, a total base number of 7 mgKOH/g or more.

Abstract: The spray dried plasma by the nature of its characteristics and the process by which it is made allows for a dried plasma with reduced pathogens. It has at least three aspects of pathogen reduction that results in a plasma product with reduced or no pathogens. The first aspect relates to a spray drying disposable and machine that eliminates or minimizes the introduction of pathogens into the spray drying process and is referred to as the anti-contamination process. The second aspect of pathogen reduction relates to the spray drying process and parameters that reduces pathogens that may be present in the donor plasma, and/or inhibit pathogen growth and/or pathogen proliferation introduced by the donor plasma. The third aspect results in reduced pathogens occurring during storage of the dried plasma wherein the manufacturing and storage conditions are such that pathogens are reduced, and/or pathogen growth and/or pathogen proliferation are inhibited.

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the mean size of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment.

Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Apparatus and methods provide compliance management tools such as for respiratory pressure therapy. In some versions, a respiratory pressure therapy system may include one or more processors, such as of a data server, configured to communicate with a computing device and/or a respiratory pressure therapy device. The respiratory pressure therapy device may be configured to deliver respiratory pressure therapy to a patient for a session. The computing device may be associated with the patient. The processor(s) may be further configured to compute a therapy quality indicator of the session from usage data relating to the session. The therapy quality indicator may be a number derived from contributions of a plurality of usage variables for the session in the usage data. The processor(s) may be further configured to present, such as by transmitting, the therapy quality indicator to the computing device. The therapy quality indicator may promote patient compliance.

Abstract: A performance instrument for a vehicle wherein an electronic device receives one or more operational quantities from internal sensors and/or external sensors and represents the one or more operational quantities as an analog clock face so that each clock hand is a function of one of the one or more operational quantities. The analog clock face representation provides at-a-glance apparency of the operational quantities for a user of the vehicle.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: W—X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: Systems and methods for managing a power budget are provided. The method includes designating, by a power budget manager implemented on at least one processor, each of one or more applications with an individual quality of service (QoS) designation, the one or more applications executable by the at least one processor, assigning, by the power budget manager, a throttling priority to each of the one or more applications based on the individual QoS designations, determining, by the power budget manager, whether a platform mitigation threshold is exceeded, and responsive to determining that the platform mitigation threshold is exceeded, throttling, by the power budget manager, processing power allocated to at least one application of the one or more applications based on the throttling prioritization.

Abstract: A method of treating plasma with a pretreatment solution that has a physiologically compatible spray dry stable acidic substance (SDSAS) and an amino acid, prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.

Abstract: Method for producing an object by means of additive manufacturing, wherein said method comprises the steps of: receiving, in a process chamber, a bath of material, wherein a surface level of said bath of material defines an object working area; solidifying, by a solidifying device, a selective layer-part of said material on said surface level; controlled oxidisation, of waste particles originating from said solidifying of said material, by controlling an oxygen level, such that oxidised waste particles are obtained and ignition of said waste particles is avoided. Apparatus for producing an object by means of additive manufacturing.

Abstract: Embodiments include exerciser device placement in the development of an integrated circuit. Aspects of the invention include obtaining a design of an integrated circuit and creating a dynamic power blockage map for the integrated circuit. Aspects also include updating the integrated circuit design by placing one or more exercisers on the integrated circuit, wherein a location of the one or more exercisers on the integrated circuit is based on at least in part on the dynamic power blockage map. Based on a determination that the updated integrated circuit design complies with one or more design constraints, aspects further include outputting the updated integrated circuit design.

Abstract: A crossbow having an energy storage system configured for storing energy when a bowstring is cocked at full-draw and releasing at least a portion of the stored energy when a trigger is pulled releasing the bowstring. The stored energy is defined by an area under a power-curve or draw-curve of the crossbow. The power-curve is defined by the force required to draw the bowstring from an un-cocked position to the cocked position. Between the un-cocked position and an intermediate position, the force required to draw the bowstring is substantially proportional to the draw distance. Between the intermediate position and the cocked position, the force required to draw the bowstring is substantially constant. When the cocked bowstring is released, at least a portion of the stored energy is transferred in the form of kinetic energy of an arrow or bolt nocked on the cocked bowstring.

Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.

Abstract: A method of controlling a concentration or range of concentrations of a liquid or gas in an enclosure is provided. The method includes positioning an injection station within the enclosure. the injection station includes a liquid or gas source, a sprayer assembly and a system that delivers the liquid or gas from the liquid or gas source to the sprayer assembly. A concentration level of the liquid or gas in the environment surrounding the injection station is monitored using a sensor and the sensor providing a signal indicative of the concentration level to a controller. The controller controls the flow of the liquid or gas to the sprayer assembly based on the signal.

Abstract: An inductive sensing device comprises first (16) and second (24) loops, the first loop (16) being coupled with a capacitor to form a resonator circuit (20), and the resonator circuit and second loop being coupled via an active buffering component (28). The active buffering component provides voltage to current amplification, and an output of the buffering component drives a current in the second loop. Conductive lines forming each of the first and second loop parts are radially spaced apart.

Abstract: An apparatus (20) for use in inductive sensing includes a loop antenna (26) and a signal generator (24) for driving the antenna, these forming a resonator circuit (22). The resonator circuit is drivable in a drive state in which the antenna is driven at resonance to thereby generate electromagnetic signals. The arrangement further includes a switching means (28) for switchably inhibiting the drive state of the antenna This allows in use controllable switching of the antenna in and out of the drive state to thereby control switching signal generation on and off.