Abstract: An apparatus (20) for use in inductive sensing includes a loop antenna (26) and a signal generator (24) for driving the antenna, these forming a resonator circuit (22). The resonator circuit is drivable in a drive state in which the antenna is driven at resonance to thereby generate electromagnetic signals. The arrangement further includes a switching means (28) for switchably inhibiting the drive state of the antenna This allows in use controllable switching of the antenna in and out of the drive state to thereby control switching signal generation on and off.

Abstract: Embodiments of the disclosure relate to an antenna unit. The antenna unit includes a first antenna plate and a second antenna plate. The second antenna plate is spatially disposed from the first antenna plate. A glass frame is disposed between the antenna plates, defining an internal cavity. The antenna unit also includes a printed circuit board (PCB), a first and second integrated circuits (IC) mounted to the at least one PCB. The first IC is configured to send/receive signals at a first frequency. The second IC is configured to send/receive signals at a second frequency different from the first frequency. The antenna unit also includes a waveguide elements configured to transmit signals at the first and second frequencies through respective first and second waveguide channels. The antenna plates, the glass frame, and PCB comprise a material that transmits at least 50% of incident light in the visible spectrum.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: An exercise machine is disclosed. The exercise machine comprises a tension generating device. The exercise machine comprises a translatable arm mount coupled to the tension generating device. The exercise machine comprises an arm coupled to the translatable arm mount. The exercise machine comprises a cable coupled to the tension generating device via the arm.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z??(I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: A method of storing energy is disclosed. The method comprises heating a material that comprises a CO2 sorbed product and an additive to desorb CO2 from the material and to convert the CO2 sorbed product to a CO2 sorbent. The additive is selected such that it at least partially prevents during heating (i) sintering of the CO2 sorbent and/or the CO2 sorbed product; and (ii) the formation of a crust on the material, the crust minimising or preventing the CO2 sorbent and CO2 from reacting with one another to form the CO2 sorbed product in a subsequent CO2 absorption step. Also disclosed is a composition used to sorb and desorb CO2 in a thermal battery, and a system for implementing the method, the system using the composition.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z??(I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z5 (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity 10 is implicated.

Abstract: A picture frame comprising a picture carrier portion and a frame portion, the picture carrier portion to carry a picture member; the frame portion comprising frame members with: an outer side member hingedly connected at a first hinge connection to the picture carrier portion; a back member hingedly connected at a second hinge connection to the outer side member, and an inner side member hingedly connected at a third hinge connection to the back member, wherein in an assembled position: the outer side member forms an outer side of the frame, the back member forms a back of the frame, and; the inner side member forms an inner side of the frame, wherein a connection system is arranged to lock the inner side member to the picture carrier portion.

Abstract: An open roof assembly for use in a vehicle roof of a vehicle comprises a moveably arranged closure member for selectively covering or at least partially exposing an opening in the vehicle roof. Further, an electric motor operatively coupled to the closure member is provided for moving the closure member. A control unit is operatively coupled to the electric motor for controlling the closure member. The control unit is configured to control a position of the closure member during normal driving conditions, and to release control of the position of the closure member, when a vehicle acceleration exceeds a predetermined acceleration threshold. Thus, upon a high force on the closure member, induced by the high acceleration and weight of the closure member, damage may be prevented by absorbing the high forces in a motion of the closure member and a resistance of the electric motor.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z??(I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: A sensing unit for use in-body comprises a variable impedance circuit for connection to the distal end of a transmission line and reflecting a carrier signal received from the transmission line. The variable impedance circuit comprises a variable impedance component having an impedance which varies non-linearly with applied voltage, a sensor for generating a voltage in response to a stimulus and a voltage bias system for creating a voltage bias for the variable impedance component. The voltage bias sets the operation point of the variable impedance component, such that the voltage changes from the sensor change the impedance of the variable impedance component non-linearly.

Abstract: The invention provides a magnetic inductive sensing device (30) comprising a loop antenna (10) for inductively coupling with electromagnetic (EM) signals emitted from a medium in response to stimulation of the medium with electromagnetic excitation signals. The device includes an electromagnetic shield (36) element which is arranged such as to intercept electromagnetic signals travelling to or from the antenna. The shield element is formed of conductive material such as to block electrical field components of incident signals but further incorporates a non-conductive gap in the material so as to prevent the formation of eddy currents. A loop of the antenna is broken by an opening, the opening being bridged by a capacitor, and the device comprises a signal processing means which is electrically coupled to the antenna via only a single point of the antenna, located to one side of the opening.

Abstract: The invention provides a magnetic inductive sensing system for sensing electromagnetic signals emitted from a body in response to electromagnetic excitation signals applied to the body. The electromagnetic signals are generated and sensed by the same loop resonator which comprises a single-turn loop antenna and a tuning capacitor. The loop antenna of the resonator and a signal generation means for exciting the resonator to generate excitation signals are together configured so as to optimize the value of a ratio between the radial frequency of the generated electromagnetic excitation signals and a reference frequency of the antenna, where the reference frequency is the frequency for which one wavelength of the generated excitation signals (waves) matches the circumferential length of the antenna. This ratio, which corresponds to a normalized radial frequency of the generated excitation signals, is maintained between a value of 0.025 and 0.50.

Abstract: A system for producing images directly on a surface includes an operational curing system comprised of a thermal acquisition system, a distance monitoring device, and a directed radiant energy source. The system also includes a support assembly for supporting the operational curing system relative to a substrate and a computer-based control system processing data and controlling the operational curing system and the support assembly.

Abstract: The invention enables digital music content to be downloaded to and used on a portable wireless computing device. An application running on the wireless device has been automatically adapted to parameters associated with the wireless device without end-user input (e.g. the application has been configured in dependence on the device OS and firmware, related bugs, screen size, pixel number, security models, connection handling, memory etc. This application enables an end-user to browse and search music content on a remote server using a wireless network; to download music content from that remote server using the wireless network and to playback and manage that downloaded music content. The application also includes a digital rights management system that enables unlimited legal downloads of different music tracks to the device and also enables any of those tracks stored on the device to be played so long as a subscription service has not terminated.

Abstract: Embodiments of the disclosure relate to an antenna unit. The antenna unit includes a first antenna plate and a second antenna plate. The second antenna plate is spatially disposed from the first antenna plate. A glass frame is disposed between the antenna plates, defining an internal cavity. The antenna unit also includes a printed circuit board (PCB), a first and second integrated circuits (IC) mounted to the at least one PCB. The first IC is configured to send/receive signals at a first frequency. The second IC is configured to send/receive signals at a second frequency different from the first frequency. The antenna unit also includes a waveguide elements configured to transmit signals at the first and second frequencies through respective first and second waveguide channels. The antenna plates, the glass frame, and PCB comprise a material that transmits at least 50% of incident light in the visible spectrum.

Abstract: An imaging device includes an optical system having a lens stack having at least one lens element, an image sensor, and at least one controller. The at least one lens element is configured to transition between a minimum focus distance and a maximum focus distance. The image sensor is positionally fixed a distance from the lens stack. The imaging device is configured to capture multiple images as the at least one lens element transitions between the minimum focus distance and the maximum focus distance to generate composite, stacked image.

Abstract: An apparatus (20) for use in inductive sensing includes a loop antenna (26) and a signal generator (24) for driving the antenna, these forming a resonator circuit (22). The resonator circuit is drivable in a drive state in which the antenna is driven at resonance to thereby generate electromagnetic signals. The arrangement further includes a switching means (28) for switchably inhibiting the drive state of the antenna This allows in use controllable switching of the antenna in and out of the drive state to thereby control switching signal generation on and off.

Abstract: An exercise machine is disclosed. The exercise machine comprises a tension generating device. The exercise machine comprises a translatable arm mount coupled to the tension generating device. The exercise machine comprises an arm coupled to the translatable arm mount. The exercise machine comprises a cable coupled to the tension generating device via the arm.