Abstract: Antibodies which bind to activated members of the erbB, TNF, and IgSF family of receptors and pharmaceutical compositions comprising the same are disclosed. Peptides and mimetics of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are also described. Methods of using such antibodies, peptides, and mimetics in tumor therapeutic, prophylactic, imaging and diagnostic applications are disclosed.

Abstract: A linear measurement device for measuring a wheelchair user for fitting a wheelchair, with a measuring bar having with a scale and a fixed locater attached at a first end. A second locator opposing the first locater moves on the measuring bar to a selected position for determining a distance measurement relative to the fixed locator for fitting the wheelchair user to the wheelchair. A method of measuring for wheelchair fitting with a linear measurement apparatus is disclosed.

Abstract: A balance tool for evaluating weight distribution of a wheelchair positioned on an elongated platform with a support extending from a lower surface and a linear scale, a measuring bar slideably movable relative to the linear scale for making measurements of horizontal distances between a center of mass and the center of the front wheels and the rear wheels, for determining the relative weight carried by the wheels and for adjusting the position of the wheels to have the rear wheels carry a substantial majority of the weight. A method of adjusting the balance of a wheelchair is disclosed.

Abstract: A wheelchair-accessible treadmill with a safety system allowing wheelchair users to exercise without the risk off steering off-course, tipping over, or rolling backwards off the treadmill. The wheelchair is secured by straps or similar means to two or more linear bearings that move along the side of the treadmill on rods or in tracks. When securely fastened, these allow the wheelchair to move forward and backward on the treadmill belt. The treadmill belt may be wider than standard, the height may be lower than standard, and a ramp may be used for access. An optical sensor may be used to determine the forward and backward movement of the wheelchair user. Wheelchair specific programs may be available through the control panel.

Abstract: Wheelchair hand rim device comprised of a heat conducting tubular hand rim and a continuous circumferential elastomeric interface that has a cross-sectional contour comprised of an outwardly extending horizontal member having a proximal end coupled to an outboard side of a wheel rim transitioning into a downwardly depending member terminating to a distal end coupled to an inboard upper portion of the tubular hand rim such that a majority of the tubular hand rim is exposed and devoid of the elastomeric interface. When braking, a user only uses the heat conducting tubular hand rim. When pushing, the user grips across both the tubular hand rim and the contoured elastomeric interface, which deforms to fit the hand, thereby providing improved comfort, frictional coupling, and impact attenuation.

Abstract: Antibodies which bind to activated members of the erbB, TNF, and IgSF family of receptors and pharmaceutical compositions comprising the same are disclosed. Peptides and mimetics of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are also described. Methods of using such antibodies, peptides, and mimetics in tumor therapeutic, prophylactic, imaging and diagnostic applications are disclosed.

Abstract: This invention pertains to the general field of chemical and biological assays which employ electrochemiluminescence (ECL), also referred to as electrogenerated chemiliminescence. More particularly, the present invention pertains to certain classes of chemical moieties which strongly quench ECL, and the use of these ECL quenchers in combination with ECL labels, for example, in ECL assay methods which employ an ECL quencher and an ECL label. One class of such quenching moieties are those which comprise at least one benzene moiety. Sub-classes of such quenching moieties are those which comprise at least one phenol moiety, quinone moiety, benzene carboxylic acid, and/or benzene carboxylate moiety.

Abstract: A method is disclosed for reducing the variance in the coolant consumption of components of a turbo-machine, in particular a gas turbine. The components are provided with one or more holes for the passage of a coolant, wherein a surface roughness existing inside the holes is reduced by mechanical finishing. The method is characterized by mechanical finishing that is performed by reshaping rough points that cause the surface roughness using a cold working process such as at least one of beating, pressing and rolling. The method permits a simple reduction of the surface roughness without creating finishing residues that could result in obstructions of the holes.

Abstract: A platelike projecting component portion of a component used in gas turbines or other similar applications includes a surface upon which hot gas acts and cooling bores through which a cooling medium is capable of flowing. Effective cooling is achieved by providing at least one plenum assigned solely to the component portion. The plenum is arranged so as to be directly adjacent to the surface upon which hot gas acts and through which the cooling medium is capable of flowing to provide convective heat transfer. The cooling bores are designed as blow-out orifices which emanate from the plenum and issue the cooling medium onto the surface upon which hot gas acts, thereby forming a cooling film.

Abstract: A method is disclosed for reducing the variance in the coolant consumption of components of a turbo-machine, in particular a gas turbine. The components are provided with one or more holes for the passage of a coolant, wherein a surface roughness existing inside the holes is reduced by mechanical finishing. The method is characterized by mechanical finishing that is performed by reshaping rough points that cause the surface roughness using a cold working process such as at least one of beating, pressing and rolling. The method permits a simple reduction of the surface roughness without creating finishing residues that could result in obstructions of the holes.

Abstract: A platelike projecting component portion (1) of a gas turbine or the like, with a surface (2) upon which hot gas acts and with cooling bores (12) through which a cooling medium is capable of flowing. Effective cooling is achieved in that at least one plenum (10; 30; 50) assigned solely to the component portion (1) is provided, which is arranged so as to be directly adjacent to the surface (2) upon which hot gas acts and through which the cooling medium is capable of flowing convectively, and in that, to form a cooling film, the cooling bores are designed as blow-out orifices (12; 52) which emanate from the plenum (10; 30, 50) and which issue on the surface (2) upon which hot gas acts.

Abstract: A hand rim assembly for a wheelchair wheel is disclosed, which includes an larger diameter hand rim and a smaller diameter hand rim. In one embodiment, the hand rim assembly is biasly coupled to the wheelchair wheel by a plurality of shock absorbing resilient fasteners. The shock absorbing resilient fasteners generally lessen the shock impact to the user's hands, arms, and shoulders, thus reducing the potential for repetitive stress injury and the like. In another embodiment, the smaller diameter hand rim has a different exterior coefficient of friction than that of the larger diameter rim so that users can use the hand rim with a higher coefficient of friction for propulsion and the rim with a lower coefficient of friction for braking. In addition, the rim used for braking, typically the smaller diameter rim, is formed of a thermally conductive material to reduce the potential for burning of the user's hands during braking.

Abstract: A method for forming a thermally stable honeycomb panel which may be used constructing large mirrors employs thermally stable composite planks comprised of about 50% graphite fibers and of about 50% borosilicate glass. These planks which are formed by hot pressing in vacuum serve as a basic construction material.The thermally stable honeycomb panel is comprised of a core member, a backplate member, and a faceplate member which are bonded by bonding process after a wet frit paste is first applied and then dried to remove volatile solvents. The bonding is completed in an oven in an air atmosphere at a temperature sufficient to melt the glass in the frit paste after the organic binder material is boiled out. After holding the honeycomb panel components at a predetermined temperature for ensuring that all the glass in the frit is melted, the bonded panel is allowed to cool to room temperature.

Abstract: A method of bonding a graphite fiber reinforced glass matrix composite to a metal structure comprising depositing a layer of eutectic alloy metal component to the bond surfaces of the metal and composite followed by placing the thus treated bond surfaces of the metal and composite together with a layer of eutectic alloy containing such metal therebetween. The metal-bond-composite is then heated to melt the alloy and bond the composite to the metal. Articles formed by such a process are also described. The method has particular utility in bonding cooling channel containing metal bases to graphite-glass composite laser mirrors.

Abstract: A method of bonding a graphite fiber reinforced glass matrix composite to a metal structure comprising depositing a layer of eutectic alloy metal component to the bond surfaces of the metal and composite followed by placing the thus treated bond surfaces of the metal and composite together with a layer of eutectic alloy containing such metal therebetween. The metal-bond-composite is then heated to melt the alloy and bond the composite to the metal. Articles formed by such a process are also described. The method has particular utility in bonding cooling channel containing metal bases to graphite-glass composite laser mirrors.