Abstract: The present disclosure provides isolated promoters, transgene expression cassettes, vectors, kits, and methods for treatment of C9ORF72 associated diseases, including ALS and FTD.

Abstract: Techniques for specifying and implementing a software application targeted for execution on a multiprocessor array (MPA). The MPA may include a plurality of processing elements, supporting memory, and a high bandwidth interconnection network (IN), communicatively coupling the plurality of processing elements and supporting memory. In some embodiments, software code may specify one or more cell definitions that include: program instructions executable to perform a function and one or more language constructs. The software code may further instantiate first, second, and third cell instances, each of which is an instantiation of one of the one or more cell definitions, where the instantiation includes configuration of the one or more language constructs such that: the first and second cell instances communicate via respective communication ports and the first and second cell instances are included in the third cell instance.

Abstract: Embodiments are directed to association of storage objects in a multi-tenant, cloud-based storage environment. More specifically, a first object can be made available in the file system of the environment and can be accessed, for example, by its file or object name. At some point thereafter, an auxiliary object can be provided that is related to the first object. For example, this auxiliary object can comprise metadata or other content associated with or related to the first object. According to one embodiment, this auxiliary object can be assigned an identifier that not only uniquely identifies the auxiliary object but also identifies, within the identifier itself, the relationship to the first object. This relational naming can be used to track the relationship between objects, e.g., to update the auxiliary object based on changes to the first object, but without a separate mapping of the objects.

Abstract: The technologies described herein are generally directed to configuring carrier aggregation zones based on transmission information in a fifth generation (5G) network or other next generation networks. For example, a method described herein can include identifying, by carrier aggregation equipment including a processor, carrier transmission information corresponding to a first carrier signal and a second carrier signal. The method can further include analyzing, by the carrier aggregation equipment, the carrier transmission information to determine first overlap zone information representative of a first carrier overlap zone for the first carrier signal and the second carrier signal. Further, based on the first overlap zone information, the method includes facilitating configuring transmission parameter information representative of a transmission parameter applicable to transmission of the first carrier signal, to enable carrier aggregation by network equipment within the first carrier overlap zone.

Abstract: A controller and method of controlling a mobile device. The controller is coupled to a mobile device through a mobile communications environment. The controller is coupled to the mobile communications environment at a location remote from the mobile device, and includes a receiver that receives data from the mobile device, a processor that evaluates the data received from the mobile device based upon rules for the mobile device, and a transmitter that sends data to the mobile device to at least one of alert the user to a condition and modify current operating parameters on the mobile device.

Abstract: A method, a computer system, and a computer program product for data validation in a microservice environment is provided. Embodiments of the present invention may include receiving a request based on an application configuration validation. Embodiments of the present invention may include determining a schema is not defined based on the request. Embodiments of the present invention may include generating the schema using machine learning. Embodiments of the present invention may include using the generated schema for a plurality of validations.

Abstract: A method is disclosed for a database system that includes a set of data blocks comprising records having attributes. The set of data blocks are instances of at least one block type. The block type is defined by a subset of one or more attributes of the attributes. An instance of the block type comprises records having one distinct group of values of the subset of attributes. The method includes detecting that a subset of one or more data blocks of the block type, of the set of data blocks, reached a first maximum number of records. The method includes determining an additional attribute of the attributes to define a new block type by the combination of the additional attribute and the subset of attributes that define the block type. The method includes creating one or more data blocks which are instances of the new block type.

Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir, (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

Abstract: Systems, apparatus, and methods for human-to-machine negotiation. Self-driving vehicles are expected to greatly improve the quality and efficiency of human life. Unfortunately, self-driving vehicles have struggled to effectively communicate with other human drivers. Various aspects of the present disclosure are directed to fleets that can bargain as a collective group. While the present disclosure describes a fleet of self-driving vehicles, the concepts are broadly applicable to any fleet of participants (machine, human, and/or hybrids). A transaction ledger in combination with a fleet of informed observers allows for systemic efficiencies that would not otherwise be possible, even among human drivers. Specifically, once enough informed observers are present (e.g., a fleet) cooperative bargaining becomes much more desirable than adverse bargaining.

Abstract: Methods and apparatus for retrieving and delivering content in a network. In one embodiment, unique data codes representative of content are generated by a network entity. The data codes are distributed to viewers either via a physical medium or on a display of similar content. The user device requests the content from the network by reading the data code. The requested content is delivered directly to the requesting device or provided to another device identified by the requesting device or user. In another alternative, the unique data code may be representative of the user or subscriber himself. This type of data code may be generated by the network or the device, and enables the user to access content he is entitled to via another device or terminal by delivery of information contained in the data code (or the code itself) to the network.

Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

Abstract: A method, a computer system, and a computer program product for data validation in a microservice environment is provided. Embodiments of the present invention may include receiving a request based on an application configuration validation. Embodiments of the present invention may include determining a schema is not defined based on the request. Embodiments of the present invention may include generating the schema using machine learning. Embodiments of the present invention may include using the generated schema for a plurality of validations.

Abstract: Apparatus and methods for providing enhanced or interactive features over a network. In one embodiment, the exemplary apparatus and methods leverage extant high-bandwidth capabilities of a managed network, and are implemented to enable a user to create a playlist of content, clips, advertisements, from among currently broadcast content, stored content, user generated content, web or other network content. The user can upload user-generated or other content to the network such as for selection into a playlist at higher rates using a network operator-provided wireless dongle. Additional interactive features include, among other, enhancements which enable user participation individually or with other subscribers in live or recorded content-based group activities (such as e.g., cooking, exercising, group viewing, dating, and learning/teaching). Further interactive gaming and couponing options are also provided.

Abstract: Methods and apparatus for organizing a distributed network based on routine usage data. In one exemplary embodiment, devices analyze routine usage data via e.g., machine learning and/or other heuristics to determine a set of routine rules and/or routine trigger conditions. Multiple devices may be assigned routine rules and/or routine trigger conditions that establish a fog network. Various described embodiments may incorporate time-shifted control plane operation and/or ledger-based control plane operation; these variants do not require central network management. Other optimizations may include dynamic selection of network topologies and/or routing technologies.

Abstract: Methods and apparatus for organizing a distributed network based on routine usage data. In one exemplary embodiment, devices analyze routine usage data via e.g., machine learning and/or other heuristics to determine a set of routine rules and/or routine trigger conditions. Multiple devices may be assigned routine rules and/or routine trigger conditions that establish a fog network. Various described embodiments may incorporate time-shifted control plane operation and/or ledger-based control plane operation; these variants do not require central network management. Other optimizations may include dynamic selection of network topologies and/or routing technologies.

Abstract: A method is disclosed for a database system that includes a set of data blocks comprising records having attributes. The set of data blocks are instances of at least one block type. The block type is defined by a subset of one or more attributes of the attributes. An instance of the block type comprises records having one distinct group of values of the subset of attributes. The method includes detecting that a subset of one or more data blocks of the block type, of the set of data blocks, reached a first maximum number of records. The method includes determining an additional attribute of the attributes to define a new block type by the combination of the additional attribute and the subset of attributes that define the block type. The method includes creating one or more data blocks which are instances of the new block type.

Abstract: Methods and apparatus for organizing a distributed network based on routine usage data. In one exemplary embodiment, devices analyze routine usage data via e.g., machine learning and/or other heuristics to determine a set of routine rules and/or routine trigger conditions. Multiple devices may be assigned routine rules and/or routine trigger conditions that establish a fog network. Various described embodiments may incorporate time-shifted control plane operation and/or ledger-based control plane operation; these variants do not require central network management. Other optimizations may include dynamic selection of network topologies and/or routing technologies.

Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.

Abstract: Apparatus and methods for providing enhanced or interactive features over a network. In one embodiment, the exemplary apparatus and methods leverage extant high-bandwidth capabilities of a managed network, and are implemented to enable a user to create a playlist of content, clips, advertisements, from among currently broadcast content, stored content, user generated content, web or other network content. The user can upload user-generated or other content to the network such as for selection into a playlist at higher rates using a network operator-provided wireless dongle. Additional interactive features include, among other, enhancements which enable user participation individually or with other subscribers in live or recorded content-based group activities (such as e.g., cooking, exercising, group viewing, dating, and learning/teaching). Further interactive gaming and couponing options are also provided.