Abstract: Methods for producing heterologous proteins are disclosed. In particular, the present disclosure provides improved methods of producing desired proteins, including multi-subunit proteins such as antibodies, with a higher yield and improved purity. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.

Abstract: A surgical system includes a control device, a touch screen display, and a GUI displayed on the touch screen display. A parameter icon has a parameter area, a first set point, a second set point, a parameter line extending from the first set point to the second set point, and a value orb located on the parameter line. The location of the value orb on the parameter line corresponds to a control position of the control device. A parameter value area is located under the parameter line and extends from the first set point to the value orb. A numerical parameter value is located in the parameter area. The parameter line represents a range of parameter values from the first set point to the second set point, and when the control device is a foot pedal, a range of travel of the foot pedal.

Abstract: A stacked, collaborative engagement ammunition round is presented. The round includes plural stacked miniaturized projectiles where such projectiles separate after launch and then swarm as a group towards a target or targets. At launch, the projectiles may fly in a preselected formation, leader-follower towards the target. Or, the projectiles may deploy propellers, tri-copter or quad-copter vanes, and self steer swarming to the target. Each projectile has its own miniaturized guidance, navigation and control components, autopilot, cameras, transmitter, receiver, antennae, power source, sensors, fuzes and/or flex circuits.

Abstract: Systems and methods create a digital geospatial display of facilities to aid facility management. In one implementation, a system retrieves data for a plurality of facilities from various databases, including, but not limited to, map data for creating maps, location data for the facilities, and resource data for the facilities. The system marks the locations of the facilities on a map display using a facility icon. The facility icon comprises one or more resource status areas, each of which convey information about the state of a resource at a facility. The system calculates the resource status areas of the facility icons based at least on the resource data.

Abstract: Processes for producing and purifying recombinant proteins are disclosed. In particular, the present disclosure provides processes of producing and purifying multi-subunit proteins expressed in yeast or filamentous fungal cells. The production and/or purification of such proteins are monitored for impurities, preferably using lectin binding assays, such that one or more process parameters may be adjusted to maximize the amount of desired recombinant protein and minimize the amount of glycosylated impurities. The processes can also be monitored for other undesired product-associated impurities, such as aggregates and nucleic acids. In exemplary embodiments, the recombinant proteins are multi-subunit proteins, such as antibodies, the host cell is a yeast, such as Pichia pastoris, and the glycosylated impurity is a glycovariant of the desired recombinant polypeptide, such as an N-linked and/or O-linked glycovariant.

Abstract: Processes for producing and purifying recombinant proteins are disclosed. In particular, the present disclosure provides processes of producing and purifying multi-subunit proteins expressed in yeast or filamentous fungal cells. The production and/or purification of such proteins are monitored for impurities, preferably using lectin binding assays, such that one or more process parameters may be adjusted to maximize the amount of desired recombinant protein and minimize the amount of glycosylated impurities. The processes can also be monitored for other undesired product-associated impurities, such as aggregates and nucleic acids. In exemplary embodiments, the recombinant proteins are multi-subunit proteins, such as antibodies, the host cell is a yeast, such as Pichia pastoris, and the glycosylated impurity is a glycovariant of the desired recombinant polypeptide, such as an N-linked and/or O-linked glycovariant.

Abstract: An information handling system includes a processor and a management controller separate from the processor. The management controller is operable to boot the information handling system to a system service management module, direct the system service management module to execute diagnostics code on the processor and to store a result from the execution of the diagnostics code in a predetermined memory location. The management controller is also operable to retrieve the result from the predetermined memory location.

Abstract: Methods for producing heterologous proteins are disclosed. In particular, the present disclosure provides improved methods of producing desired proteins, including multi-subunit proteins such as antibodies, with a higher yield and improved purity. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.

Abstract: A feedback control mechanism for a fermentation of yeast cells to make recombinant proteins uses a respiratory quotient measurement which adjusts the levels of oxygenation and/or fermentable sugar feed. The feedback control mechanism permits well controlled cultures that produce good amounts of product while avoiding toxic accumulation of ethanol. Additionally, recombinant proteins so produced have excellent qualitative properties, such as excellent homogeneity and proper inter-subunit assembly.

Abstract: An alarm notification system comprising: a central server; the central server configured to monitor the status of one or more remote alarms, and in the event of the status of a first remote alarm changing, generating an alert to send to a first remote device; the central server further configured to determine if the first remote device is connected to the alarm notification system by a persistent connection, and in the event that the first remote device is connect via persistent connection sending an alarm notification message via the persistent connection; and in the event that the first remote device is not connected via a persistent connection sending an alarm notification message via a push notification service.

Abstract: A surgical system includes a control device, a touch screen display, and a GUI displayed on the touch screen display. A parameter icon has a parameter area, a first set point, a second set point, a parameter line extending from the first set point to the second set point, and a value orb located on the parameter line. The location of the value orb on the parameter line corresponds to a control position of the control device. A parameter value area is located under the parameter line and extends from the first set point to the value orb. A numerical parameter value is located in the parameter area. The parameter line represents a range of parameter values from the first set point to the second set point, and when the control device is a foot pedal, a range of travel of the foot pedal.

Abstract: An information handling system includes a processor and a management controller separate from the processor. The management controller is operable to boot the information handling system to a system service management module, direct the system service management module to execute diagnostics code on the processor and to store a result from the execution of the diagnostics code in a predetermined memory location. The management controller is also operable to retrieve the result from the predetermined memory location.

Abstract: Processes for producing and purifying recombinant proteins are disclosed. In particular, the present disclosure provides processes of producing and purifying multi-subunit proteins expressed in yeast or filamentous fungal cells. The production and/or purification of such proteins are monitored for impurities, preferably using lectin binding assays, such that one or more process parameters may be adjusted to maximize the amount of desired recombinant protein and minimize the amount of glycosylated impurities. The processes can also be monitored for other undesired product-associated impurities, such as aggregates and nucleic acids. In exemplary embodiments, the recombinant proteins are multi-subunit proteins, such as antibodies, the host cell is a yeast, such as Pichia pastoris, and the glycosylated impurity is a glycovariant of the desired recombinant polypeptide, such as an N-linked and/or O-linked glycovariant.

Abstract: Methods for producing heterologous proteins are disclosed. In particular, the present disclosure provides improved methods of producing desired proteins, including multi-subunit proteins such as antibodies, with a higher yield and improved purity. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.

Abstract: Described herein is technology for, among other things, selecting a representative thumbnail from a video clip. The technology involves analyzing frames of the video clip to determine which frames are stable, the result of the analysis being a number of segments of stable frames. From the stable segments, a number of candidate segments are selected, where candidate segments are those segments determined to a degree of certainty to be program content. The representative thumbnail is then selected from among the frames of the candidate segments.

Abstract: Provided is a combined umbilical cord clamp, cutter, disinfectant, and data collecting system which reduces the risk of cord infections due to unsanitary birth conditions. Also provided is an identification system which aids in the collection of birth statistics.

Abstract: The invention provides a nozzle-mixed burner for use in an endothermic process such as hydrogen reforming or ammonia reforming or ethylene cracking or EDC cracking. The burner comprises a fuel duct extending axially through a wall of the furnace. The fuel duct delivers gaseous fuel to an array of nozzles extending laterally to spray the fuel outwardly into an annular chamber defined by a cap. Combustion air is delivered to the chamber by way of a primary air duct. A convergent-divergent section of the duct and an outwardly divergent section of the chamber together form a radially extending venturi. Combustion of the fuel, supplemented by the venturi effect, draws the air through the duct by natural inspiration.

Abstract: The present invention relates generally to methods of preserving an organ for transplantation. Specifically, the present invention is directed towards treating an organ with a hemoglobin-carbon monoxide complex to preserve the organ before transplantation.

Abstract: Systems and methods create a digital geospatial display of facilities to aid facility management. In one implementation, a system retrieves data for a plurality of facilities from various databases, including, but not limited to, map data for creating maps, location data for the facilities, and resource data for the facilities. The system marks the locations of the facilities on a map display using a facility icon. The facility icon comprises one or more resource status areas, each of which convey information about the state of a resource at a facility. The system calculates the resource status areas of the facility icons based at least on the resource data.