Patents by Inventor Markus H. Frank

Markus H. Frank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ABCB5(+) STEM CELLS FOR TREATING OCULAR DISEASE
    Publication number: 20180064762
    Abstract: Various aspects and embodiments of the present invention are directed to methods of treating a subject having an ocular condition, methods of isolating ocular stem cells, methods of selecting and/or producing ocular grafts for transplantation, and methods of promoting ocular cell regeneration as well as to grafts and preparations containing isolated ocular stem cells characterized by the expression of ABCB5 on their cell surface.
    Type: Application
    Filed: October 30, 2017
    Publication date: March 8, 2018
    Applicants: VA Boston Healthcare System, Schepens Eye Research Institute, Children's Medical Center Corporation
    Inventors: Markus H. Frank, Natasha Y. Frank, Bruce Ksander, Paraskevi Evi Kolovou
  • Targeting ABCB5 for cancer therapy
    Patent number: 9855342
    Abstract: The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: January 2, 2018
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Natasha Y. Frank, Mohamed H. Sayegh
  • ABCB5(+) stem cells for treating ocular disease
    Patent number: 9801912
    Abstract: Various aspects and embodiments of the present invention are directed to methods of treating a subject having an ocular condition, methods of isolating ocular stem cells, methods of selecting and/or producing ocular grafts for transplantation, and methods of promoting ocular cell regeneration as well as to grafts and preparations containing isolated ocular stem cells characterized by the expression of ABCB5 on their cell surface.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: October 31, 2017
    Assignees: VA Boston Healthcare System, Schepens Eye Research Institute, Children's Medical Center Corporation
    Inventors: Markus H. Frank, Natasha Y. Frank, Bruce Ksander, Paraskevi Evi Kolovou
  • Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
    Patent number: 9561264
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: February 7, 2017
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • TARGETING ABCB5 FOR CANCER THERAPY
    Publication number: 20160136297
    Abstract: The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
    Type: Application
    Filed: January 25, 2016
    Publication date: May 19, 2016
    Applicant: The Brigham and Women's Hospital, Inc
    Inventors: Markus H. Frank, Natasha Y. Frank, Mohamed H. Sayegh
  • WOUND HEALING AND TISSUE ENGINEERING
    Publication number: 20160106782
    Abstract: The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds.
    Type: Application
    Filed: May 9, 2014
    Publication date: April 21, 2016
    Applicants: Va Boston Healthcare System, The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation
    Inventors: Markus H. Frank, Natasha Y. Frank, Dennis P. Orgill, George F. Murphy
  • Targeting ABCB5 for cancer therapy
    Patent number: 9266946
    Abstract: The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: February 23, 2016
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Natasha Y. Frank, Mohamed H. Sayegh
  • THERAPEUTIC AND DIAGNOSTIC METHODS RELATING TO CANCER STEM CELLS
    Publication number: 20160009804
    Abstract: The present invention relates in part to the discovery of genes that are deregulated in cancer stem cells (e.g., melanoma stem cells). In some aspects, methods for treating individuals having melanoma are provided; the methods involve modulating (e.g., inducing, inhibiting, etc.) the activity of the cancer stem cell associated genes. In other aspects, cell surface genes that are upregulated in melanoma stem cells are targeted for the selective isolation, detection, and killing of cancer stem cells in melanoma. Other aspects of the invention relate to reagents, arrays, compositions, and kits that are useful for diagnosing and treating melanoma.
    Type: Application
    Filed: September 28, 2015
    Publication date: January 14, 2016
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Natasha Y. Frank
  • ABCB5(+) STEM CELLS FOR TREATING OCULAR DISEASE
    Publication number: 20150374756
    Abstract: Various aspects and embodiments of the present invention are directed to methods of treating a subject having an ocular condition, methods of isolating ocular stem cells, methods of selecting and/or producing ocular grafts for transplantation, and methods of promoting ocular cell regeneration as well as to grafts and preparations containing isolated ocular stem cells characterized by the expression of ABCB5 on their cell surface.
    Type: Application
    Filed: February 19, 2014
    Publication date: December 31, 2015
    Applicants: VA BOSTON HEALTHCARE SYSTEM, SCHEPENS EYE RESEARCH INSTITUTE, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Markus H. Frank, Natasha Y. Frank, Bruce Ksander
  • TARGETING ABCB5 FOR CANCER THERAPY
    Publication number: 20140302031
    Abstract: The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
    Type: Application
    Filed: April 14, 2014
    Publication date: October 9, 2014
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Natasha Y. Frank, Mohamed H. Sayegh
  • Targeting ABCB5 for cancer therapy
    Patent number: 8697072
    Abstract: The invention related to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: April 15, 2014
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Natasha Y. Frank, Mohamed H. Sayegh
  • ABCB5 POSITIVE MESENCHYMAL STEM CELLS AS IMMUNOMODULATORS
    Publication number: 20130315880
    Abstract: The present invention is directed to purified preparations of dermal mesenchymal stem cells that are characterized by the cell surface expression of the ABCB5 P-glycoprotein. The cells may be used for any purpose that mesenchymal stem cells from other course are used. For instance they may be administered to treat an organ transplant recipient to improve allograft survival or as a treatment to patients with autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 28, 2013
    Applicant: Children's Medical Center Corporation
    Inventor: Markus H. Frank
  • Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
    Patent number: 8507273
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: August 13, 2013
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • ABCB5 positive mesenchymal stem cells as immunomodulators
    Patent number: 8455245
    Abstract: The present invention is directed to purified preparations of dermal mesenchymal stem cells that are characterized by the cell surface expression of the ABCB5 P-glycoprotein. The cells may be used for any purpose that mesenchymal stem cells from other course are used. For instance they may be administered to treat an organ transplant recipient to improve allograft survival or as a treatment to patients with autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: June 4, 2013
    Assignee: Children's Medical Center Corporation
    Inventor: Markus H. Frank
  • Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7P15-21 and uses thereof
    Patent number: 8425876
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: April 23, 2013
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7P15-21 AND USES THEREOF (FRANK)
    Publication number: 20120034196
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Application
    Filed: October 24, 2011
    Publication date: February 9, 2012
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7P15-21 and uses thereof
    Patent number: 8076091
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: December 13, 2011
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • THERAPEUTIC AND DIAGNOSTIC METHODS RELATING TO CANCER STEM CELLS
    Publication number: 20110287034
    Abstract: Genes that are deregulated in cancer stem cells (e.g., melanoma stem cells) are disclosed. Methods which involve modulating (e.g., inducing, inhibiting, etc.) the activity of the cancer stem cell associated genes are used to treat individuals having melanoma. Cell surface genes that are upregulated in melanoma stem cells are targeted for the selective isolation, detection, and killing of cancer stem cells in melanoma.
    Type: Application
    Filed: November 13, 2009
    Publication date: November 24, 2011
    Applicant: The Brigham and Womens Hospital, Inc.
    Inventors: Markus H. Frank, Natasha Y. Frank
  • TARGETING ABCB5 FOR CANCER THERAPY
    Publication number: 20110165149
    Abstract: The invention related to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
    Type: Application
    Filed: March 10, 2011
    Publication date: July 7, 2011
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Natasha Y. Frank, Mohamed H. Sayegh
  • Targeting ABCB5 for cancer therapy
    Patent number: 7928202
    Abstract: The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: April 19, 2011
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Natasha Y. Frank, Mohamed H. Sayegh