Patents by Inventor Markus H. Frank

Markus H. Frank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7P15-21 AND USES THEREOF
    Publication number: 20100145030
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Application
    Filed: February 9, 2010
    Publication date: June 10, 2010
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: MARKUS H. FRANK, MOHAMED H. SAYEGH
  • GENE ENCODING A MULTIDRUG-RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7P15-21 AND USES THEREOF
    Publication number: 20090162873
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell s susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Application
    Filed: November 19, 2008
    Publication date: June 25, 2009
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • TARGETING ABCB5 FOR CANCER THERAPY
    Publication number: 20090117117
    Abstract: The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
    Type: Application
    Filed: April 11, 2008
    Publication date: May 7, 2009
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Natasha Y. Frank, Mohamed H. Sayegh
  • Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7p15-2 and uses thereof
    Patent number: 7465554
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: December 16, 2008
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
    Patent number: 6846883
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: January 25, 2005
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • Tumor suppressors associated with human chromosome 21q22
    Publication number: 20030119044
    Abstract: The present invention is directed to tumor suppressor polypeptides and to polynucleotide sequences by which they are encoded. It includes assays designed for detecting mutations that predispose a patient to certain forms of cancer and therapeutic methods in which suppressor proteins or genes encoding the proteins are administered to patients.
    Type: Application
    Filed: November 26, 2002
    Publication date: June 26, 2003
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventor: Markus H. Frank
  • Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
    Publication number: 20020037522
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Application
    Filed: June 5, 2001
    Publication date: March 28, 2002
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh