Abstract: The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-demethylated and/or O-demethylated reticuline and/or derivatives thereof, comprising cultivating the recombinant host of the invention in a culture medium under conditions in which the one or more genes encoding the cytochrome P450 enzymes is/are expressed. The reticuline and derivatives thereof are useful for providing access to naturally unavailable and chemically difficult-to-produce starting materials for opioids.

Abstract: A method of controlling an aircraft that operates in a network of fixed landing platforms, includes defining at least one alternate landing area) having an entry point and an exit point; b) pre-planning at least one flight trajectory to the entry point; c) automatically steering the aircraft along the flight trajectory; d) to perform a landing procedure at the alternate landing area, transferring control of the aircraft to an online planning device, preferably on board the aircraft, upon reaching the entry point; e) automatically scanning the alternate landing area, preferably according to a predetermined search pattern, and searching the alternate landing area for a landing site by active sensor technology; f) if a suitable landing site is identified, automatically carrying out a landing procedure of the aircraft at the landing site by the online planning device, otherwise g) automatically steering the aircraft to the exit point.

Abstract: A method of monitoring the temperature of a solid state switch in an aircraft solid state power controller. The method includes: measuring an electric current (I) flowing through the solid state switch; calculating, based on the measured electric current (I), an introduced electric power (Pel) that is introduced into the solid state switch within the predefined time period (?t); calculating an increase in temperature (?T) of the solid state switch that is caused by the introduced electric power (Pel); calculating an actual temperature (Tact) of the solid state switch by adding the calculated increase in temperature (?T) to an ambient temperature (Tamb); and comparing the calculated actual temperature (Tact) with a predefined temperature threshold (Tth) and determining an overheat condition if the calculated actual temperature (Tact) exceeds the predefined temperature threshold (Tth).

Abstract: The invention relates to a switch cabinet with a switch cabinet door which closes the switch cabinet and has a door lock which can be actuated via a door handle, the switch cabinet door having a door status sensor which has a magnetic field sensor being adapted to distinguish an open state of the switch cabinet door from a closed state of the switch cabinet door by means of a detected magnetic field change, characterized in that at least the magnetic field sensor of the door status sensor is accommodated within the door handle in a region of the door handle which is magnetically permeable to the environment of the switch cabinet.

Abstract: A production cell includes: at least one robot arranged to handle products; at least one buffer area for intermediate storage of products inside the production cell; a vision system with cameras arranged to determine, based on images from the cameras, the identity and the location of objects in the production cell a plurality of production modules, each production module comprising at least one Hardware Module configured to process products; and a plurality of module attachment locations, each module attachment location being configured to connect with an interface section of a production module through at least a physical connection and a power connection.

Abstract: Font recommendation techniques are described that provide recommendations of fonts based on a variety of factors, automatically and without user intervention in real time. This is performable in a variety of ways by addressing a wide range of considerations as part of machine learning, examples of which include context, popularity, similarity, customization, and topic compatibility.

Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.