Abstract: An asymmetric half bridge flyback converter, comprising a first primary side switching device and a second primary side switching device coupled in series between a supply voltage and a reference potential, a transformer, wherein one end of a primary side winding of the transformer is coupled to a node between the first primary side switching device and the second primary side switching device, a capacitor, wherein a resonant circuit including at least the primary side winding and the capacitor is coupled in parallel to the second primary side switching device, and a controller controlling the switches devices. The second primary side switching device is configured to prevent or reduce current flow in both directions when switched off.

Abstract: A method for controlling a motor vehicle driving on a road in a current lane is described. Environmental data are determined by means of a sensor. At least one utility value functional is determined based on the environmental data, wherein the utility value functional assigns a utility value for the at least one other road user at a predefined point in time in each case for different spatial areas of the current lane and/or the at least one other lane. A two-dimensional representation of the at least one utility functional is determined. At least one probable trajectory of the at least one other road user is determined based on the two-dimensional representation of the utility value functional by applying pattern recognition to the two-dimensional representation. A control unit, a motor vehicle and a computer program are also described.

Abstract: A control system for use in a motor vehicle is used for monitoring a current driving situation of the motor vehicle, based on surroundings data of the host motor vehicle in the current driving situation, obtained from at least one surroundings sensor situated on the host motor vehicle. The control system is used to recognize lanes, lane boundary lines, lane markings, and/or other motor vehicles in an area in front of, to the side of, and/or behind the host motor vehicle. In addition, the control system is used to determine at least one driving parameter for each other motor vehicle present in the surroundings of the host motor vehicle, based on the provided surroundings data, and to generate a plurality of possible trajectories for the future travel course for each of the other motor vehicles, based on the driving parameter determined in each case.

Abstract: The invention relates to a method for determining a driving corridor for a motor vehicle (1). The motor vehicle (10) comprises at least one camera (22) and a control unit (24), the camera (24) being designed to generate images of a front region (30) in front of the motor vehicle (10) and to forward these images to the control unit (24). The control unit (24) comprises a machine learning module (28) having an artificial neural network. The method comprises the following steps: an image of the front region (30) in front of the motor vehicle (10) is obtained by the at least one camera (22); characteristic image features of the image are extracted by means of the artificial neural network; by means of the same artificial neural network, image points (32) which delimit the driving corridor of the motor vehicle (10) and/or at least one driving corridor adjacent to the driving corridor are determined on the basis of the extracted characteristic image features.

Abstract: A control system for use in a motor vehicle is used for monitoring a current driving situation of the motor vehicle, based on surroundings data of the host motor vehicle in the current driving situation, obtained from at least one surroundings sensor situated on the host motor vehicle. The control system is used to recognize lanes, lane boundary lines, lane markings, and/or other motor vehicles in an area in front of, to the side of, and/or behind the host motor vehicle. In addition, the control system is used to determine at least one driving parameter for each other motor vehicle present in the surroundings of the host motor vehicle, based on the provided surroundings data, and to generate a plurality of possible trajectories for the future travel course for each of the other motor vehicles, based on the driving parameter determined in each case.

Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein IIb/IIIa antagonists for imaging of thrombi.

Abstract: The present invention relates to BET-protein-inhibitory, in particular BRD4-inhibitory 5-aryltriazoloazepines of the general formula (I) in which R1, R2, R3 and R4 have the meanings given for the general formula (I), to pharmaceutical compositions comprising the compounds according to the invention, and to the prophylactic and therapeutic use thereof for hyperproliferative disorders, especially for neoplastic disorders. The present invention further relates to the use of BET protein inhibitors in viral infections, in neurodegenerative disorders, in inflammatory diseases, in atherosclerotic disorders and in male fertility control.

Abstract: An example relates to a method for operating a converter comprising (i) determining whether a valley for switching the converter in a quasi-resonant mode is available within a predetermined time range; (ii) selecting the valley if it is available within the predetermined time range; and (iii) changing the mode for operating the converter if the valley is not available within the predetermined time range.

Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.

Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.

Abstract: This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogs thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).

Abstract: What is described are BET protein-inhibitory, especially BRD2-, BRD3- and BRD4-inhibitory, bicyclo- and spino-substituted pyrrolo- and pyrazolodiazepines of the general formula I in which X, Y, n, m, R1, R2, R3, R4 and R5 are each as defined in the description, to intermediates for preparation of the inventive compounds, to pharmaceutical compositions comprising the inventive compounds, and to the prophylactic and therapeutic use thereof for hyperproliferative disorders, especially for tumour disorders. Also described is the use of the compounds according to the invention as BET protein inhibitors for benign hyperplasias, for atherosclerotic disorders, for sepsis, for autoimmune disorders, for vascular disorders, for viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for male fertility control.

Abstract: BET protein-inhibitory, especially BRD2-, BRD3- and BRD4-inhibitory, 4-substituted pyrrolo- and pyrazolodiazepines of the general formula I are described, in which X, Y, n, m, p, R1, R2, R3, R4 and R5 are each as defined in the description, as are pharmaceutical compositions comprising the inventive compounds, and the prophylactic and therapeutic use thereof in the case of hyperproliferative disorders, especially in the case of neoplastic disorders. Also described is the use of the inventive compounds as BET protein inhibitors in benign hyperplasias, in atherosclerotic disorders, in sepsis, in autoimmune disorders, in vascular disorders, in viral infections, in neurodegenerative disorders, in inflammatory disorders and in male fertility control.

Abstract: The present invention relates to BET-protein-inhibitory, in particular BRD4-inhibitory 5-aryltriazoloazepines of the general formula (I) in which R1, R2, R3 and R4 have the meanings given for the general formula (I), to pharmaceutical compositions comprising the compounds according to the invention, and to the prophylactic and therapeutic use thereof for hyperproliferative disorders, especially for neoplastic disorders. The present invention further relates to the use of BET protein inhibitors in viral infections, in neurodegenerative disorders, in inflammatory diseases, in atherosclerotic disorders and in male fertility control.

Abstract: This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).

Abstract: The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.

Abstract: The invention describes novel direct synthesis methods for converting a precursor into a PET-tracer with a 18F-fluoromethoxy-group. The invention is also directed to novel and stable precursors for the direct radiosynthesis of protected derivatives of O—([18F]Fluoromethyl)tyrosines.

Abstract: This invention relates to pyrimidine derivatives of general formula I in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, as inhibitors of cyclin-dependent kinases and VEGF-receptor tyrosine kinases, their production as well as their use as medications for treatment of various diseases.

Abstract: Aza- and polyazanthranyl amides and their use as medicaments in the treatment of diseases caused by persistent angiogenesis are described, as well as the intermediates used in the preparation of the aza- and polyazanthranyl amides.

Abstract: The invention relates to a process for preparing an alcoholic solution of an alkali metal alkoxide from alkali metal hydroxide and alcohol in a reaction column, the alcohol and the alkali metal hydroxide being conducted in countercurrent, which is characterized in that a reflux ratio of at least 0.05 is established in the reaction column.