Abstract: A system and method including receiving sets of sensor data associated with sensors configured to monitor one or more systems. Sensor fingerprints are generated for each set of sensor data based on the sensor data. At least one proximity value is computed for each sensor by comparing the fingerprint of that sensor with another fingerprint. Clusters of similar sensors are identified based at least upon the proximity values of the sensors.

Abstract: The present invention relates to several systems and methods for clamping, machining, inspecting, and/or correcting workpieces in an integrated machine.

Abstract: The present invention provides methods for the treatment of non-alcoholic steatohepatitis (NASH) including advanced fibrotic and/or cirrhotic stages of NASH. The methods include administration of a compound comprising a double stranded RNAi (dsRNAi) oligonucleotide, or a pharmaceutically acceptable salt thereof, to the patient. The dsRNAi oligonucleotide optionally contains an antisense strand and a sense strand, wherein the antisense strand and the sense strand form a duplex region, and wherein the antisense strand comprises a region of complementarity to a KHK mRNA target sequence.

Abstract: The present invention relates generally to a sophisticated system and software to assist users deciding what video programing to watch. Based on analysis of viewing by users and their friends (which are the most reliable and accurate influencers on peoples viewing decisions), the system provides tools, ratings, recommendations and alerts. Specifically, the system leverages various forms of unique software tools and artificial intelligence processing to produce accurate and relevant information for users deciding what to watch. Given the huge and expanding amounts of video content and multiple viewing platforms, finding out what to watch is a crucial problem for a very high percentage (over 80%) of all video viewers, and the current invention represents a crucial and timely solution to this problem.

Abstract: The present invention relates generally to a very sophisticated system and software to collect a large range of hybrid user dam in relation to viewing of video content on any viewing platforms including television, online and other forms systems available on a real-time basis. Specifically, embodiments of the present invention provide systems and software for hybrid data collection and storage for large numbers of different data types and complex output analyses instantaneously. Further, because of the single source of the user data, system data outputs are already, and uniquely, in a verified (and validated) form and there are no requirements of additional verification or validations procedures such as identity (or device) graphing.

Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: There is provided an aerosol delivery device including a power source and controller, the controller being configured to control delivery of power from the power source to an aerosol-generator during a single aerosol-generation event according to a first power delivery profile and a subsequent power delivery profile having a different profile to the first power delivery profile, wherein the first power delivery profile has a predetermined output based on the voltage of the power supply.

Abstract: A support bracket for a hanger assembly that supports one or more non-structural components in a building comprises a web having opposite upper and lower edge margins and opposite left and right edge margins. The web defines at least one non-structural component opening configured to receive and support one of the non-structural components. The at least one non-structural component opening having a closed shape. A first flange extends from the upper edge margin of the web in a first direction and is configured to be attached to at least one support rod. A second flange extends from the lower edge margin of the web in a second direction opposite the first direction. The left and right edge margins of the web define partial openings. Each of the partial openings having an open shape that is a segment of the closed shape of the at least one non-structural component opening.

Abstract: A building system including one or more memory devices configured to store instructions that, when executed on one or more processors, cause the one or more processors to collect building device data of a building device, generate a time correlated data stream for a data point, and generate a time correlated reliability data stream for the data point. The building device data includes a plurality of data samples of the data point. The time correlated data stream includes values of the plurality of data samples of the data point. The time correlated reliability data stream includes a plurality of reliability values time correlated to corresponding values of the plurality of data samples of the data point and indicating reliability of the values of the plurality of data samples of the data point.

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the Invention include compounds having the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R1c, R1d, R1e, R1f, R1g, R2, X, L and A are as defined herein.

Abstract: A lubricating member for a hair removal device, in which the lubricating member includes a lubricating material, in which the lubricating material includes a polyglutamic acid (PGA) material. Also disclosed is a lubricating composition including: a matrix material and a lubricating material, in which the lubricating material includes a PGA material and the PGA includes at least 5% of the lubricating composition by weight. Also disclosed is a method of forming a corresponding lubricating member.

Abstract: An inspection apparatus includes an inspection signal source configured to irradiate a wafer with an inspection ray having a frequency in a range of 0.1 terahertz (THz) to 10 THz, a curved rail, a probe mount configured to move along the curved rail, and first and second probes coupled to the probe mount, wherein the first probe is configured to detect the inspection ray transmitted through the wafer, and the curved rail has a curved surface convex toward the first and second probes.

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30).

Abstract: In one embodiment, a method for authenticating a user with an electronic device is disclosed. The method incudes receiving digital sensor data from a motion sensor over a signal acquisition time period; deleting a beginning portion of the digital sensor data prior to the signal acquisition time period; suppressing signal components in the data associated with voluntary movement of the user; signal processing the suppressed digital sensor data to extract signal features representing neuro muscular tone of the user; tabulating the extracted signal features over periods of time into a feature vector table; executing a predictive model with the feature vector table; generating a numerical degree of matching level based on the feature vector table and the user parameter set; and making a determination to either authorize the user or not based on the numerical degree of matching level. The predictive model is trained by a user parameter set.

Abstract: A method for designing an energy system is provided. An abstract structure of the energy system is determined based on a pre-defined abstract model for each one of the plurality of components. Configuration(s) of a system sizing associated with the energy system are determined. Each of the configuration(s) of the system sizing is determined based on the abstract structure and a set of requirements associated with the abstract structure of the energy system. For each of the configuration(s) of the system sizing, a respective complex structure of the energy system is determined based on a pre-defined complex model for each of the components and the abstract structure, and a performance of the respective complex structure of the energy system is determined based on a set of requirements associated with the energy system. The energy system is designed based on respective performances determined for the configuration(s) of the system sizing.