Abstract: The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The invention also relates to novel intermediates. Finally, the invention provides a pharmaceutical composition comprising the insulin derivatives of the invention and the use of such a composition in the treatment or prevention of medical conditions relating to diabetes.

Abstract: A magazine device (100) for a double-row arrangement of successive cartridges (200) be inserted into a barrel of a firearm. A magazine housing (110) has an opening (150) to be placed below the cartridge chamber when inserted into the firearm for successive delivery of each cartridge (200). Two of the four opposite walls (112, 114) of the magazine housing (110) in a transition region below the opening (150) form a feed section (160) for successively feeding each cartridge (200) into the opening (150). The feed section (160) formed in the transition stage by two opposite walls (112, 114) of the magazine housing (110) is of a curved form.

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

Abstract: A device that includes a sensor unit and a processing unit. The sensor unit is configured to detect at least one measured value at a predetermined point in time. The processing unit is configured to carry out a self-calibration of the device as a function of the detected measured value. A method for self-calibration of a device is also described.

Abstract: The present invention relates to novel covalently linked bi-functional fusion proteins comprising insulin and EGF(A) analogues or derivatives thereof, and their pharmaceutical use. Furthermore, the invention relates to pharmaceutical compositions comprising such bi-functional compounds, and to the use of such compounds for the treatment or prevention of medical conditions relating to diabetes and dyslipidaemia associated with diabetes.

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X—R2, and wherein “X” is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (11a) or (IIb) Also described are diboron conjugates represented by the general Formula (I?), which is: R1?-X?—R2?, in which either the moeities R1? or R2? or X? carry a drug that is covalently attached to the diboron compound.

Abstract: A magazine device (100) for a double-row arrangement of successive cartridges (200) be inserted into a barrel of a firearm. A magazine housing (110) has an opening (150) to be placed below the cartridge chamber when inserted into the firearm for successive delivery of each cartridge (200). Two of the four opposite walls (112, 114) of the magazine housing (110) in a transition region below the opening (150) form a feed section (160) for successively feeding each cartridge (200) into the opening (150). The feed section (160) formed in the transition stage by two opposite walls (112, 114) of the magazine housing (110) is of a curved form.

Abstract: The invention refers to a computer-implemented method of analyzing video data to identify affiliates of an object of interest, the method comprising: identifying a plurality of occurrences of the object of interest in the video data; determining a set of potential affiliates for the object of interest from a plurality of other objects in the video data based on a criterion of closeness between the object of interest at each occurrence and each other object; analyzing the set of potential affiliates to obtain a similarity score for each potential affiliate at each occurrence from the plurality of occurrences, each similarity score indicating a degree of similarity with respect to a selected reference potential affiliate in the set of potential affiliates; and identifying a potential affiliate as an affiliate of the object of interest based on the similarity scores.

Abstract: The invention provides a method for processing and analyzing forensic video data using a computer program, the method comprising the steps of recording the forensic video data; providing supplementary data related to the recorded video data, wherein the supplementary data may be provided from or input by a source external of the computer program, in particular a human, or wherein the supplementary data may be extracted from the forensic video data by the computer program in an initial analyzing step; analyzing the forensic video data by the computer program using the supplementary data; and displaying a part of the forensic video data, the displayed part being based on a result of the analyzing step.

Abstract: The present invention relates to a computer-implemented method of identifying a physical object, comprising the steps of providing image data comprising an image object representing a physical object, analyzing the image data to extract identification data for the image object, providing supplementary data associated with a particular physical object, and determining whether the image object corresponds to the particular physical object based on the identification data and supplementary data.

Abstract: A valve drive with a snap function includes a rotary drive input, a lead screw connected to or formed by the rotary drive input, a slide in threaded engagement with the lead screw to form a screw thread, the slide being mechanically connected or connectable to a valve body and being movable in the direction of a longitudinal axis. A bearing housing is provided in which the lead screw is mounted so as to be rotatable about the longitudinal axis and stationary in the direction of the longitudinal axis. The bearing housing is held against a displacement along the longitudinal axis by a releasable locking device, countering the preload force of a snap spring.

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X—R2, and wherein “X” is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (11a) or (IIb) Also described are diboron conjugates represented by the general Formula (I?), which is: R1?-X?—R2?, in which either the moeities R1? or R2? or X? carry a drug that is covalently attached to the diboron compound.

Abstract: This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.

Abstract: The disclosure proceeds from a system, in particular from a portable power tool system, having at least one mobile functional module which has at least one communications unit for communicating electronic data, having at least one building infrastructure device which has at least one communications unit for communicating with the functional module, and having at least one control and/or regulation unit which is at least intended to use an evaluation of a communication between the functional module and the building infrastructure device to at least infer a position of the functional module. It is proposed that the functional module is at least intended to sense at least one article-specific parameter, a user-specific parameter and/or an environment-specific parameter and/or to transmit said parameter(s) at least to the building infrastructure device.

Abstract: A system for recognizing an occupancy status of, in particular unmarked, parking facilities is provided, which system includes: a) a plurality of occupancy sensors that are disposed, at a specific distance from one another, on or above an area to be detected; b) a central monitoring unit on which a virtual image of the area to be detected is stored and which is embodied to communicate with the occupancy sensors and to receive sensor data or information regarding the occupancy status at the location or in the vicinity of the respective sensor, the positions of the individual occupancy sensors being known to the central monitoring unit, and the central monitoring unit being embodied to create a virtual image of the occupancy status of the area to be detected and to recognize vacant and occupied sub-areas as a function of the sensor data.

Abstract: The present invention relates to an aqueous solution comprising burlulipase which is characterized in that it contains calcium ions. In particular, it also relates to corresponding pharmaceuticals. Such pharmaceuticals are suitable for the treatment of exocrine pancreatic insufficiency. These pharmaceuticals are particularly suitable for treating patients having cystic fibrosis and in pediatrics. Another aspect of the present invention relates to container-packaged solutions and pharmaceuticals as mentioned above, which are containers produced by the blow-fill-seal method, and to methods for producing such packaged solutions and pharmaceuticals.

Abstract: The present invention relates to a computer-implemented method of identifying a physical object, comprising the steps of providing image data comprising an image object representing a physical object, analyzing the image data to extract identification data for the image object, providing supplementary data associated with a particular physical object, and determining whether the image object corresponds to the particular physical object based on the identification data and supplementary data.

Abstract: The invention provides a method of analyzing video data comprising the steps of recording the video data using one or more video recording devices; analyzing at least one video frame of the video data to extract identification information regarding a specific object of interest that is comprised in a watch list of a plurality of objects of interest, the watch list including at least one entry for each of the plurality of objects of interest; computing a matching value by comparing the extracted identification information with predetermined identification information of the specific object of interest; and storing object data and the matching value as an additional entry in the watch list in association with the specific object of interest.

Abstract: A parking lot management system includes a management server, a vehicle sensor for detecting a motor vehicle in a parking space and for transmitting a detection result to the management server, and furthermore a configuration server as well as a mobile device. The mobile device is designed to transmit an identification of the vehicle sensor to the configuration server. The configuration server is designed to transmit to a vehicle sensor, whose identification it previously received from the mobile device, a configuration that includes communication data for communicating with the management server.

Abstract: A method for controlling a parking lot sensor, which includes a sensor for scanning a predetermined measuring area, includes steps of determining an expected fluctuation of vehicles in the measuring area, of determining a scanning frequency on the basis of the expected fluctuation and of controlling, as a function of the scanning frequency, the sensor respectively for carrying out a scan.