Patents by Inventor Mary Ann Franden

Mary Ann Franden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High expression promoters
    Patent number: 7989206
    Abstract: Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: August 2, 2011
    Assignee: E.I. du Pont de Nemours and Company Alliance for Sustainable Energy LLC
    Inventors: Paul V. Viitanen, Luan Tao, Yuying Zhang, Perry G. Caimi, Laura McCole, Min Zhang, Yat-Chen Chou, Carol M. McCutchen, Mary Ann Franden
  • with improved ethanol production in medium containing concentrated sugars and acetate
    Patent number: 7897396
    Abstract: Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas strains further engineered to reduce activity of the himA gene were found to have increased ethanol production in comparison to a parental strain, when cultured in mixed-sugars medium comprising xylose, and, in particular, in the presence of acetate.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: March 1, 2011
    Assignees: E.I. du Pont de Nemours and Company
    Inventors: Perry G. Caimi, Yat-Chen Chou, Mary Ann Franden, Kyle Knoke, Luan Tao, Paul V. Viitanen, Min Zhang, Yuying Zhang
  • ZYMOMONAS WITH IMPROVED XYLOSE UTILIZATION IN STRESS CONDITIONS
    Publication number: 20110014670
    Abstract: Strains of xylose utilizing Zymomonas with improved xylose utilization and ethanol production during fermentation in stress conditions were obtained using an adaptation method. The adaptation involved continuously growing xylose utilizing Zymomonas in media containing high sugars, acetic acid, ammonia, and ethanol.
    Type: Application
    Filed: December 18, 2009
    Publication date: January 20, 2011
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY & ALLIANCE FOR SUSTAINABLE ENERGY LLC
    Inventors: PERRY G. CAIMI, Mark Emptage, Xu Li, Paul V. Viitanen, Yat-Chen Chou, Mary Ann Franden, Min Zhang
  • L-arabinose fermenting yeast
    Patent number: 7846712
    Abstract: An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. Methods of producing ethanol include utilizing these modified yeast strains.
    Type: Grant
    Filed: March 19, 2007
    Date of Patent: December 7, 2010
    Assignee: Alliance for Sustainable Energy, LLC
    Inventors: Min Zhang, Arjun Singh, Eric Knoshaug, Mary Ann Franden, Eric Jarvis, Pirkko Suominen
  • with improved ethanol production in medium containing concentrated sugars and acetate
    Patent number: 7803623
    Abstract: Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas further engineered to reduce activity of the himA gene were found to have increased ethanol production in comparison to a parental strain, when cultured in medium comprising xylose and acetate.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: September 28, 2010
    Assignees: E.I. du Pont de Nemours and Company, Alliance for Sustainable Energy LLC
    Inventors: Perry G. Caimi, Yat-Chen Chou, Mary Ann Franden, Kyle Knoke, Luan Tao, Paul V. Viitanen, Min Zhang, Yuying Zhang
  • L-Arabinose Fermenting Yeast
    Publication number: 20100144041
    Abstract: An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. Methods of producing ethanol include utilizing these modified yeast strains.
    Type: Application
    Filed: March 19, 2007
    Publication date: June 10, 2010
    Applicant: MIDWEST RESEARCH INSTITUTE
    Inventors: Min Zhang, Arjun Singh, Pirkko Suominen, Eric Knoshaug, Mary Ann Franden, Eric Jarvis
  • Ethanol production in fermentation of mixed sugars containing xylose
    Patent number: 7629156
    Abstract: Xylose-utilizing Z. mobilis strains were found to have improved ethanol production when grown in medium containing mixed sugars including xylose if sorbitol or mannitol was included in the medium. The effect was seen in concentrations of mixed sugars where no growth lag period occurs, as well as in higher sugars concentrations.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: December 8, 2009
    Assignees: E.I. du Pont de Nemours and Company, Alliance For Sustainable Energy, LLC
    Inventors: Paul V. Viitanen, Carol M. Mc Cutchen, Xu Li, Mark Emptage, Perry G. Caimi, Min Zhang, Yat-Chen Chou, Mary Ann Franden
  • HIGH EXPRESSION ZYMOMONAS PROMOTERS
    Publication number: 20090246876
    Abstract: Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: PAUL V. VIITANEN, LUAN TAO, YUYING ZHANG, PERRY G. CAIMI, LAURA MCCOLE, MIN ZHANG, YAT-CHEN CHOU, CAROL M. MCCUTCHEN, MARY ANN FRANDEN
  • ZYMOMONAS WITH IMPROVED XYLOSE UTILIZATION
    Publication number: 20090246846
    Abstract: Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: PAUL V. VIITANEN, LUAN TAO, YUYING ZHANG, PERRY G. CAIMI, CAROL M. MCCUTCHEN, LAURA MCCOLE, MIN ZHANG, YAT-CHEN CHOU, MARY ANN FRANDEN
  • ZYMOMONAS WITH IMPROVED ETHANOL PRODUCTION IN MEDIUM CONTAINING CONCENTRATED SUGARS AND ACETATE
    Publication number: 20090221078
    Abstract: Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas further engineered to reduce activity of the himA gene were found to have increased ethanol production in comparison to a parental strain, when cultured in medium comprising xylose and acetate.
    Type: Application
    Filed: October 30, 2008
    Publication date: September 3, 2009
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Perry G. Caimi, Yat-Chen Chou, Mary Ann Franden, Kyle Knoke, Luan Tao, Paul V. Viitanen, Min Zhang, Yuying Zhang
  • ZYMOMONAS WITH IMPROVED ETHANOL PRODUCTION IN MEDIUM CONTAINING CONCENTRATED SUGARS AND ACETATE
    Publication number: 20090203099
    Abstract: Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas strains further engineered to reduce activity of the himA gene were found to have increased ethanol production in comparison to a parental strain, when cultured in mixed-sugars medium comprising xylose, and, in particular, in the presence of acetate.
    Type: Application
    Filed: October 30, 2008
    Publication date: August 13, 2009
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Perry G. Caimi, Yat-Chen Chou, Mary Ann Franden, Kyle Knoke, Luan Tao, Paul V. Viitanen, Min Zhang, Yuying Zhang
  • Recombinant lactobacillus for fermentation of xylose to lactic acid and lactate
    Patent number: 5798237
    Abstract: A recombinant Lactobacillus MONT4 is provided which has been genetically engineered with xylose isomerase and xylulokinase genes from Lactobacillus pentosus to impart to the Lactobacillus MONT4 the ability to ferment lignocellulosic biomass containing xylose to lactic acid.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: August 25, 1998
    Assignee: Midwest Research Institute
    Inventors: Stephen K. Picataggio, Min Zhang, Mary Ann Franden, James D. Mc Millan, Mark Finkelstein