Patents by Inventor Masahiro Toyoda

Masahiro Toyoda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240131241
    Abstract: A blood purification apparatus includes a line section, a duplex pump, and a control unit. The line section includes a dialysate introduction line and a drain-liquid discharge line. The control unit is configured to execute a blood purification treatment process and a defatting washing process. The blood purification treatment process is executed when blood purification treatment is performed in which dialysate is delivered to a dialyzer. The dialysate is prepared by mixing an A-drug solution and a B-drug solution introduced into the line section and diluting the A-drug solution and the B-drug solution to predetermined concentrations. The defatting washing process is executed when defatting washing is performed in which oil and fat in the line section is removed by causing a sodium carbonate solution to flow through the line section. The sodium carbonate solution is obtained by heating the B-drug solution introduced into the line section.
    Type: Application
    Filed: December 26, 2023
    Publication date: April 25, 2024
    Applicant: NIKKISO COMPANY LIMITED
    Inventors: Satoru KAWARABAYASHI, Masahiro TOYODA, Kensaku TANAKA
  • Publication number: 20240123129
    Abstract: A blood purification apparatus includes a line section, a duplex pump, and a control unit. The line section includes a dialysate introduction line and a drain-liquid discharge line. The control unit executes a blood purification treatment process and a defatting washing process. The blood purification treatment process is executed when blood purification treatment is performed in which dialysate is delivered to a dialyzer. The dialysate is prepared by diluting an A-drug solution and a B-drug solution. The defatting washing process is executed when defatting washing is performed where oil and fat in the line section is removed by causing a sodium carbonate solution obtained from the B-drug solution introduced into the line section to flow through the line section. The control unit uses a heating unit and a deaerator when executing a bicarbonate-solution-generating process where the sodium carbonate solution is generated by a predetermined amount while carbon dioxide is discharged.
    Type: Application
    Filed: December 27, 2023
    Publication date: April 18, 2024
    Applicant: NIKKISO COMPANY LIMITED
    Inventors: Satoru KAWARABAYASHI, Masahiro TOYODA, Kensaku TANAKA
  • Patent number: 11948673
    Abstract: A blood purification system is provided that is capable of effectively utilizing accumulated histories stored during blood purification treatment and that helps take a quick and appropriate action in response to any event that occurs unsteadily or any transition of a parameter. The blood purification system includes an extracting unit that searches histories accumulated in a storage unit and extracts, as reference histories, a plurality of histories each including any of events having occurred during the current session of blood purification treatment or a plurality of histories each including a parameter approximate to that observed during the current session of blood purification treatment; a list-creating unit that creates a list of the plurality of reference histories extracted by the extracting unit; and a display control unit that controls the list created by the list-creating unit to be displayed on a display unit.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: April 2, 2024
    Assignee: Nikkiso Company Limited
    Inventors: Naoyuki Aota, Masahiro Toyoda, Yasunobu Hagiwara
  • Publication number: 20240041562
    Abstract: [Problem] To increase the flexibility, cutting ability, and/or fracture resistance of a dental file. [Solution] A cross-sectional shape of a dental file 100 includes an arc-shaped portion 111, and first to third linear portions 112 to 114 that are continuous sequentially from the arc-shaped portion 111. The diameter of a virtual circle 101 including the arc-shaped portion 111 is configured to decrease from a proximal end portion toward a distal end portion. A connection point 122 between the first and second linear portions 112 and 113, and a connection point 123 between the second and third linear portions 113 and 114 are located inside the virtual circle 101. An angle A11 that a diameter passing through a connection point 121 forms with the first linear portion 112 is set in such a manner as to increase from the proximal end portion toward the distal end portion.
    Type: Application
    Filed: September 29, 2020
    Publication date: February 8, 2024
    Inventors: Kazuhiko MATSUTANI, Masamitsu OGINO, Masahiro TOYODA, Yuto YOSHIZAWA, Hiroaki KOBAYASHI, Atsuya YAGI
  • Patent number: 11642446
    Abstract: A blood purification system is provided that is capable of effectively utilizing accumulated histories stored during blood purification treatment and that helps take a quick and appropriate action in response to a particular incident that occurs unsteadily. In a blood purification system, a history stored in a storage device includes particular incidents having occurred unsteadily in blood purification treatment. The blood purification system includes an extracting device capable of searching the histories accumulated in the storage device and extracting a desired one of the particular incidents, a calculating device capable of calculating a time when the particular incident extracted by the extracting device occurs a predetermined or more number of times as a frequent-occurrence time slot, and a display control device capable of displaying the frequent-occurrence time slot calculated by the calculating device on a display during a current session of blood purification treatment.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: May 9, 2023
    Assignee: Nikkiso Company Limited
    Inventors: Naoyuki Aota, Masahiro Toyoda, Yasunobu Hagiwara
  • Patent number: 11471574
    Abstract: A blood-purification-treatment support system is capable of making an accurate judgement of whether or not any treatment conditions for blood purification treatment should be changed. The blood-purification-treatment support system is capable of supporting blood purification treatment. The system includes a storage device that stores patient-specific patient data that are acquired on a plurality of days including at least no-treatment days on which blood purification treatment is not conducted, an estimating device that compares the patient data for the plurality of days stored in the storage device with one another and estimates a pre-treatment patient state regarding blood purification treatment, and a judging device that judges from the pre-treatment patient state estimated by the estimating device whether or not any treatment conditions for blood purification treatment should be changed.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: October 18, 2022
    Assignee: Nikkiso Company Limited
    Inventors: Hitoshi Goto, Kunihiko Akita, Masahiro Toyoda
  • Patent number: 11458238
    Abstract: A blood purification apparatus is provided that is capable of detecting an abnormal state of puncture into a blood vessel with an arterial puncture needle or a venous puncture needle.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: October 4, 2022
    Assignee: Nikkiso Company Limited
    Inventors: Hitoshi Goto, Masahiro Toyoda, Tomoya Murakami, Kunihiko Akita
  • Patent number: 11458237
    Abstract: A blood purification apparatus that detects dislodgement of a puncture needle is provided. The apparatus includes an arterial electrode, a venous electrode, a power source capable of causing a current to flow through an arterial puncture needle and a venous puncture needle that are stuck in a patient, a body-surface electrode closely attached to a body surface of the patient, a detection device capable of acquiring a heart rate of the patient in accordance with an electrical signal detected by the body-surface electrode, a monitoring device capable of monitoring in real time the current flowing through the arterial electrode or the venous electrode and a change in an impedance in a body of the patient that is detected by the detection device, and an identifying device capable of identifying a dislodged state where the arterial puncture needle or the venous puncture needle is dislodged from the patient, in accordance with the change in the impedance that is an object of monitoring by the monitoring device.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: October 4, 2022
    Assignee: Nikkiso Company Limited
    Inventors: Hitoshi Goto, Kunihiko Akita, Masahiro Toyoda
  • Patent number: 11419963
    Abstract: A blood purification apparatus with a blood circuit that allows a patient's blood to extracorporeally circulate and a blood purifier connected to the blood circuit and that purifies the blood in extracorporeal circulation are attachable, the blood purification apparatus including a dialysate introduction line through which dialysate is introduced into the blood purifier; a dialysate drain line through which waste dialysate resulting from blood purification performed by the blood purifier is drained from the blood purifier; and a concentration-detecting unit that detects a concentration of a predetermined substance in the waste dialysate flowing through the dialysate drain line.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: August 23, 2022
    Assignee: Nikkiso Company Limited
    Inventors: Satoru Kawarabayashi, Shinya Hasegawa, Tomoya Murakami, Kunihiko Akita, Masahiro Toyoda
  • Publication number: 20220119265
    Abstract: Provided are exfoliated graphite that rarely folds, rarely curls, and rarely causes corrosion of an electrode when used as the electrode material, and a method for manufacturing the exfoliated graphite. Exfoliated graphite being graphene or a laminate of graphene sheets, the exfoliated graphite having a ratio 2 D/G of 0.5 or more and 5.0 or less, the ratio 2 D/G being a peak area ratio of a 2 D band to a G band in a Raman. spectrum measured. using Raman spectroscopy, and a halogen content of 1,000 ppm or less.
    Type: Application
    Filed: February 26, 2020
    Publication date: April 21, 2022
    Applicants: SEKISUI CHEMICAL CO., LTD., OITA UNIVERSITY
    Inventors: Hiroji FUKUI, Akira NAKASUGA, Masahiro TOYODA
  • Publication number: 20220016327
    Abstract: Provided are a connection structure and a blood purifying device which are capable of enhancing the durability of seal members. This connection structure 1 is roughly configured to be provided with: a connection part 3 attached to a main body 90 which has a housing 20, a diaphragm 25, a chamber 2, and a coupling 30 for connecting an output port 27, and which has a pressure sensor 10a for detecting a pressure PK of a gas K output from the coupling 30; and a seal member which is sandwiched by the lateral surface 270 of the output port 27 and the lateral surface 302 of the coupling 30, and which moves while changing the seal position when connecting or disconnecting the chamber 2 and the connection part 3.
    Type: Application
    Filed: December 2, 2019
    Publication date: January 20, 2022
    Inventors: Hikaru Ito, Fumitoshi Henmi, Takayuki Suzuki, Masahiro Toyoda
  • Patent number: 11179507
    Abstract: A blood purification apparatus to which a blood circuit that allows a patient's blood to extracorporeally circulate and a blood purifier connected to the blood circuit and that purifies the blood in extracorporeal circulation are attachable, the blood purification apparatus including a dialysate introduction line through which dialysate is introduced into the blood purifier; a dialysate drain line through which waste dialysate resulting from blood purification performed by the blood purifier is drained from the blood purifier; and a concentration-detecting unit that detects a concentration of a predetermined substance in the waste dialysate resulting from the blood purification by the blood purifier and flowing through the dialysate drain line.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: November 23, 2021
    Assignee: Nikkiso Company Limited
    Inventors: Satoru Kawarabayashi, Shinya Hasegawa, Tomoya Murakami, Kunihiko Akita, Masahiro Toyoda
  • Patent number: 11090419
    Abstract: Provided is a blood purification apparatus which can continue to accurately monitor a blood purification treatment state even if treatment conditions are changed during blood purification treatment. The blood purification apparatus can perform real-time monitoring on the blood purification treatment state, based on a concentration change in a discharge solution which is obtained by an arithmetic device. The blood purification apparatus includes a treatment condition change device that sets or changes treatment conditions as requested, and that causes a discharge solution concentration sensor to previously detect concentration of the discharge solution under the respective treatment conditions, and a storage device that stores the concentration of the discharge solution under the respective treatment conditions which is detected by the discharge solution concentration sensor in the treatment condition change device, as a first predetermined value corresponding to the respective treatment conditions.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: August 17, 2021
    Assignee: Nikkiso Company Limited
    Inventors: Tomoya Murakami, Kunihiko Akita, Masahiro Toyoda
  • Publication number: 20210077703
    Abstract: A blood purification apparatus including a blood circuit including an arterial blood circuit and a venous blood circuit and that allows a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a blood purifier between the arterial blood circuit and the venous blood circuit that purifies the blood flowing through the blood circuit having a blood flow route through which the blood extracorporeally circulating through the blood circuit flows and a dialysate flow route through which dialysate flows, the blood flow route and the dialysate flow route being separated from each other by a blood purification membrane for purifying the blood; an ultrafiltration unit that performs ultrafiltration by filtering out water from the blood in the blood flow route through the blood purification membrane and draining the water through the dialysate flow route; and a substitution-fluid supply unit that supplies substitution fluid into the blood c
    Type: Application
    Filed: November 25, 2020
    Publication date: March 18, 2021
    Inventors: Shinya Hasegawa, Satoru Kawarabayashi, Masahiro Toyoda, Kunihiko Akita
  • Publication number: 20210077704
    Abstract: A blood purification apparatus that accurately calculates the colloid osmotic pressure of a patient's blood. A dialyzer included in the blood purification apparatus has thereinside blood flow routes and dialysate flow routes that are separated from each other by hollow fibers. An ultrafiltration pump draws out water from the blood in the blood flow routes through the hollow fibers into the dialysate flow routes. Four detecting units measure the pressures of liquid flowing into the blood flow routes, the liquid discharged from the blood flow routes, dialysate flowing into the dialysate flow routes, and the dialysate discharged from the dialysate flow routes. The pressures at the four positions, the transmembrane pressure difference can be calculated. The blood flow routes are filled with a priming solution, and the transmembrane pressure difference (TMPa) is measured. Subsequently, the blood flow routes are filled with the patient's blood, and the transmembrane pressure difference (TMPb) is measured.
    Type: Application
    Filed: November 25, 2020
    Publication date: March 18, 2021
    Inventors: Shinya Hasegawa, Satoru Kawarabayashi, Masahiro Toyoda, Kunihiko Akita
  • Patent number: 10940253
    Abstract: A blood purification apparatus where neither an arterial puncture needle nor a venous puncture needle is stuck in the patient can be checked automatically when it is attempted to activate a blood pump in an unconnected step. A blood purification apparatus includes a blood circuit for circulating blood, a dialyzer for purifying the blood, a blood pump provided to an arterial blood circuit for delivering liquid when activated, and a control device that executes a connected step when blood pump is activated with an arterial puncture needle (a) and a venous puncture needle (b) being stuck in the patient and an unconnected step in which the blood pump is activated with neither the arterial puncture needle (a) nor the venous puncture needle (b) being stuck in the patient.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: March 9, 2021
    Assignee: Nikkiso Company Limited
    Inventors: Masahiro Toyoda, Akira Sugioka
  • Patent number: 10940252
    Abstract: A blood purification apparatus with an arterial puncture needle or a venous puncture needle is stuck in the patient can be easily notified at the activation of a blood pump in an unconnected step. A blood purification apparatus includes a blood circuit for circulating blood, a dialyzer capable of purifying the blood, a blood pump provided to an arterial blood circuit for delivering a liquid, and a control device that executes a connected step in which the blood pump is activated when an arterial puncture needle (a) and a venous puncture needle (b) are in the patient and an unconnected step in which the blood pump is activated with neither the arterial puncture needle (a) nor the venous puncture needle (b) being stuck in the patient. The control device establishes, in the unconnected step, a restricted state where the behavior of the blood pump at the activation of the blood pump is restricted.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: March 9, 2021
    Assignee: Nikkiso Company Limited
    Inventors: Masahiro Toyoda, Akira Sugioka
  • Publication number: 20210052799
    Abstract: A blood purification apparatus that includes a blood circuit including an arterial blood circuit provided with an arterial puncture needle and a venous blood circuit provided with a venous puncture needle with which an access vessel is puncturable, the blood circuit allowing blood of the patient to extracorporeally circulate; a blood purifier connected to the arterial blood circuit and to the venous blood circuit and that purifies the blood flowing through the blood circuit; a blood pump provided to the arterial blood circuit; a recirculating-blood-detecting unit capable of detecting recirculating blood when the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump, the recirculating blood being blood once returned to the patient from the venous blood circuit and reintroduced into the arterial blood circuit; and a recirculation-rate-calculating unit capable of calculating recirculation rate, the recirculation rate being a proportion of the recircul
    Type: Application
    Filed: October 16, 2020
    Publication date: February 25, 2021
    Inventors: Kunihiko Akita, Shinya Hasegawa, Masahiro Toyoda
  • Patent number: 10751462
    Abstract: A medical apparatus in which the measurement of an electrocardiogram and the detection of blood leakage that may occur if an accessing unit comes off the patient can be performed accurately without fail, and with which the efficiency in the operation to be performed before the treatment can be improved. A medical apparatus includes a blood purification device including an accessing unit formed of a venous puncture needle stickable into a patient, electrocardiogram-measuring devices closely attached to a skin of the patient and being capable of measuring an electrocardiogram of the patient, and a blood-leakage-detecting device attached to a position near the accessing unit and being capable of detecting blood of the patient that may leak from the accessing unit. The medical apparatus further includes an integrated detecting device provided as a unit including the electrocardiogram-measuring device and the blood-leakage-detecting device.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: August 25, 2020
    Assignee: Nikkiso Company Limited
    Inventors: Hitoshi Goto, Masahiro Toyoda, Tomoya Murakami, Shigeaki Funamura
  • Patent number: 10737670
    Abstract: A brake fluid pressure control device for a vehicle that can perform fluid pressure control on the brake fluid pressure applied to wheel brakes. It is determined whether the pressure increasing time in the current pressure increasing control exceeds determination time which is set on the basis of the pressure increasing time in past pressure increasing control. If the pressure increasing time in the current pressure increasing control exceeds the determination time, it is determined that the road surface on which the vehicle is travelling has changed from the road surface with a low coefficient of friction to the road surface with a high coefficient of friction.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: August 11, 2020
    Assignee: NISSIN KOGYO CO., LTD.
    Inventors: Masahiro Toyoda, Teruyoshi Yamakawa