Abstract: A shoe midsole has a sole plate, a plurality of blades integrally standing on the sole plate, a cover bonded to the circumference of the sole plate, and a fluid sealed between the sole plate and the cover. A first concave part in a shape equivalent to a sole of a foot is formed on the surface of the sole plate, on which the plurality of blades stand, wherein the plurality of blades are accommodated within the first concave part. The plurality of blades are aligned at a predetermined interval in a direction nearly orthogonal to the longitudinal direction of the sole plate, and some of the plurality of blades are tilted toward the toe.

Abstract: In the method for controlling a tunable wavelength laser, information designating an oscillation wavelength is inputted. A driving condition for causing laser oscillation at a first wavelength is acquired from a memory. A control value of wavelength characteristics of the etalon and a difference between the first wavelength and a second wavelength are referred to, and a control value of wavelength characteristics of the etalon for causing laser oscillation at the second wavelength is calculated. The control value of wavelength characteristics of the etalon are assigned to the tunable wavelength laser, and a wavelength is controlled so that a wavelength sensing result becomes a first target value. Information indicating a wavelength shift amount from the designated oscillation wavelength is inputted. The wavelength sensing result is calculated as a second target value. The wavelength is controlled so that the wavelength sensing result becomes the second target value.

Abstract: A driving condition for causing the tunable wavelength laser to conduct laser oscillation at a first wavelength is acquired. a driving condition for causing the tunable wavelength laser to conduct laser oscillation at the second wavelength is calculated. The tunable wavelength laser is driven based on the driving condition of the second wavelength, feedback control that changes the driving condition of the tunable wavelength laser based on a difference between an output of the wavelength sensing unit and the target value is performed, and the tunable wavelength laser is caused to oscillate at the second wavelength. The driving condition of the tunable wavelength laser obtained by the feedback control when oscillation has occurred at the second wavelength is stored in the memory. Thereafter, the tunable wavelength laser is driven with reference to the stored driving condition of the tunable wavelength laser.

Abstract: The method for controlling a wavelength-tunable laser comprises a first step of acquiring a driving condition of the wavelength-tunable laser for laser oscillation at a first wavelength, and a second step of calculating according to the driving condition of the first wavelength and a wavelength difference between the first wavelength and a second wavelength different from the first wavelength a control value or target value of a wavelength characteristic of the second wavelength in the wavelength detection unit, so as to calculate a driving condition for driving the wavelength-tunable laser, the second step including a step of selecting according to the wavelength difference one of etalon slopes having respective gradients identical and opposite to a gradient of an etalon slope used for controlling the first wavelength.

Abstract: A novel podophyllotoxin derivative, which is capable of releasing a drug without depending on biological enzymes and can be expected to have an effective therapeutic effect and is soluble in water has been demanded. A polymer having a polyethyleneglycol structural unit and two or more succinic monoamide structural units, particularly a polymer conjugate of a podophyllotoxin in which a carboxylic acid group of polyethyleneglycol/polyaspartic acid copolymer and a hydroxyl group of podophyllotoxin and linked via an ester bond is provided.

Abstract: A method of controlling a wavelength tunable laser to control an oscillation wavelength based on a difference between a detection result of a wavelength by a wavelength detecting unit and a target value, the method includes: acquiring a first drive condition of the wavelength tunable laser to make the wavelength tunable laser oscillate at a first wavelength from a memory; calculating a second drive condition to drive the wavelength tunable laser at a second wavelength by referring to the first drive condition and a wavelength difference between the first wavelength and the second wavelength, the second wavelength differing from the first wavelength; and driving the wavelength tunable laser based on the second drive condition calculated at the calculating of the second drive condition.

Abstract: A method of controlling a wavelength-tunable laser selecting an oscillation wavelength with a combination of a plurality of wavelength selection portions of which wavelength peak is different from each other, comprising: a first step of confirming a control direction of the wavelength selection portion in a case where a setting value is changed from a first setting value for achieving the first wavelength to a second setting value for achieving the second wavelength; a second step of setting a setting value that is shifted from the second setting value in a direction that is opposite of a pre-determined changing direction on the wavelength selection portion as a prepared setting value, when the control direction confirmed in the first step is opposite to the pre-determined changing direction; and a third step of changing the prepared setting value set in the second step to the second setting value.

Abstract: There is provided a waterproof structure for the electrical junction box includes a stepwise portion in which a punched hole has to be provided for molding a locking projection on a peripheral wall of a main-body case. The waterproof structure prevents intrusion of a droplet from an outside into the main-body case via the punched hole and thereby improves waterproof performance. An extended portion 37d is provided on a left wall portion 22 of the main-body case 2 for moving the position of the punched hole which should be provided in the stepwise portion 35 toward the side of the locking projection 33. A hole-sealing portion 47a is provided at a edge portion 42a of the left wall portion 42 of the cover 4, the hole-sealing portion 47a is configured to cover the entire opening of the punched hole 37 moved toward the side of the locking projection 33 in a state where the cover is attached to the main-body case 2.

Abstract: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A? oligomers, but do not recognize soluble A? monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.

Abstract: A method of controlling a wavelength-tunable laser selecting an oscillation wavelength with a combination of a plurality of wavelength selection portions of which wavelength peak is different from each other, comprising: a first step of confirming a control direction of the wavelength selection portion in a case where a setting value is changed from a first setting value for achieving the first wavelength to a second setting value for achieving the second wavelength; a second step of setting a setting value that is shifted from the second setting value in a direction that is opposite of a pre-determined changing direction on the wavelength selection portion as a prepared setting value, when the control direction confirmed in the first step is opposite to the pre-determined changing direction; and a third step of changing the prepared setting value set in the second step to the second setting value.

Abstract: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A? oligomers, but do not recognize soluble A? monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.

Abstract: A method of controlling a wavelength-tunable laser selecting an oscillation wavelength with a combination of a plurality of wavelength selection portions of which wavelength peak is different from each other, comprising: a first step of confirming a control direction of the wavelength selection portion in a case where a setting value is changed from a first setting value for achieving the first wavelength to a second setting value for achieving the second wavelength; a second step of setting a setting value that is shifted from the second setting value in a direction that is opposite of a pre-determined changing direction on the wavelength selection portion as a prepared setting value, when the control direction confirmed in the first step is opposite to the pre-determined changing direction; and a third step of changing the prepared setting value set in the second step to the second setting value.

Abstract: A shoe midsole has a sole plate, a plurality of blades integrally standing on the sole plate, a cover bonded to the circumference of the sole plate, and a fluid sealed between the sole plate and the cover. A first concave part in a shape equivalent to a sole of a foot is formed on the surface of the sole plate, on which the plurality of blades stand, wherein the plurality of blades are accommodated within the first concave part. The plurality of blades are aligned at a predetermined interval in a direction nearly orthogonal to the longitudinal direction of the sole plate, and some of the plurality of blades are tilted toward the toe.

Abstract: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A? oligomers, but do not recognize soluble A? monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.

Abstract: There is provided a waterproof structure for the electrical junction box includes a stepwise portion in which a punched hole has to be provided for molding a locking projection on a peripheral wall of a main-body case. The waterproof structure prevents intrusion of a droplet from an outside into the main-body case via the punched hole and thereby improves waterproof performance. An extended portion 37d is provided on a left wall portion 22 of the main-body case 2 for moving the position of the punched hole which should be provided in the stepwise portion 35 toward the side of the locking projection 33. A hole-sealing portion 47a is provided at a edge portion 42a of the left wall portion 42 of the cover 4, the hole-sealing portion 47a is configured to cover the entire opening of the punched hole 37 moved toward the side of the locking projection 33 in a state where the cover is attached to the main-body case 2.

Abstract: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A? oligomers, but do not recognize soluble A? monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.

Abstract: Disclosed is an antibody having a high inhibitory effect on amyloid fibril formation. An antibody is produced by using a liposome containing a GM1 ganglioside at a predetermined ratio as an immunogen. Thus, the sequences of four types of antibodies each having a high inhibitory effect on amyloid fibril formation can be provided.

Abstract: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A? oligomers, but do not recognize soluble A? monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.

Abstract: Disclosed is an antibody having a high inhibitory effect on amyloid fibril formation. An antibody is produced by using a liposome containing a GM1 ganglioside at a predetermined ratio as an immunogen. Thus, the sequences of four types of antibodies each having a high inhibitory effect on amyloid fibril formation can be provided.

Abstract: The present inventors successfully produced monoclonal antibodies that are specific to only soluble A? oligomers, but do not recognize soluble A? monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.