Abstract: This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or ?-thalassemia).

Abstract: A plastic container has a main body portion, a neck portion and a molded feature such as an anti-rotation lug adjacent to the neck portion. The molded feature has a volume that is less than a volume that would be defined by the maximum external dimensions of the feature. This reduces the shrinkage differential between the molded feature and the neck portion, which could otherwise cause sealing problems with a closure as a result of deformation of the neck portion. A method of blow molding a plastic container with a reduced volume of the molded feature is also disclosed.

Abstract: The present invention encompasses compounds of formula (I) wherein the groups R1 to R7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: The present disclosure may include, for example, a tunable capacitor having a decoder for generating a plurality of control signals, and an array of tunable switched capacitors comprising a plurality of fixed capacitors coupled to a plurality of switches. The plurality of switches can be controlled by the plurality of control signals to manage a tunable range of reactance of the array of tunable switched capacitors. Additionally, the array of tunable switched capacitors is adapted to have non-uniform quality (Q) factors. Additional embodiments are disclosed.

Abstract: A matching system of a communication device that incorporates teachings of the present disclosure may include, for example, a controller that executes instructions facilitating selection of a subset of usage scenarios according to a usage condition of a communication device. An impedance circuit is adjusted based on a subset of different tuning scenarios corresponding to the subset of usage scenarios to facilitate an impedance match to an antenna of the communication device. A group of operational parameters is obtained for each tuning scenario change between the subset of different tuning scenarios. Multiple operational parameters obtained at each of the subset of different tuning scenarios at different times are processed for each tuning scenario and a tuning scenario is selected based on a determination as to which of the processed operational parameters correlates with a predetermined performance goal. Additional embodiments are disclosed.

Abstract: A system comprises an unmanned aerial vehicle, UAV. The UAV comprises a camera having one or more camera properties. The system is configured to provide privacy in relation to the camera when the UAV is below a predetermined altitude. The system is configured such that said privacy in relation to the camera is not provided when the UAV is above said predetermined altitude.

Abstract: The present disclosure may include, for example, a tunable capacitor having a decoder for generating a plurality of control signals, and an array of tunable switched capacitors comprising a plurality of fixed capacitors coupled to a plurality of switches. The plurality of switches can be controlled by the plurality of control signals to manage a tunable range of reactance of the array of tunable switched capacitors. Additionally, the array of tunable switched capacitors is adapted to have non-uniform quality (Q) factors. Additional embodiments are disclosed.

Abstract: An unmanned aerial vehicle, UAV, is operable in an autonomous mode. The UAV comprises an upwards-configurable sensor an actuator and a controller. The upwards-configurable sensor is configurable in an upwards-facing configuration during an autonomous procedure such that a field of view of the upwards-configurable sensor includes airspace directly above the UAV during the autonomous procedure. The controller is operable to control the actuator during the autonomous procedure based on data captured by the upwards-configurable sensor to cause the UAV to make physical contact with an object in the airspace directly above the UAV during the autonomous procedure.

Abstract: The present invention relates to polycyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R4, R7 to R10, Y and A are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: An implant driver for engaging an orthopedic implant for selective advancement and retraction of the implant. The implant driver includes a first jaw assembly comprising a helical cam surface corresponding with a first direction of rotation. The first jaw assembly is operative to engage, in response to rotation in the first direction, the implant using spherical jaw members disposed in constrictive helical channels. The implant driver includes a second jaw assembly comprising a helical cam surface corresponding with a second direction of rotation. The second jaw assembly is operative to engage, in response to rotation in the second direction, the implant using spherical jaw members disposed in constrictive helical channels. Absent rotation of the first and second jaw assemblies, the spherical jaws may not restrict relative axial movement between the implant and the implant driver to allow for advancement and/or retraction of the instrument relative to the implant.

Abstract: The present invention encompasses compounds of formula (I), wherein the groups R1 to R7 have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.

Abstract: An unmanned aerial vehicle (UAV) comprises a controller. The controller of the UAV causes the UAV to access an interior of an object. The controller of the UAV causes the UAV to clean at least part of the interior of the object.

Abstract: A UAV comprises a camera and an image processor. The camera is operable to output captured image data corresponding to a first representation of a scene within a field of view of the camera. The scene includes an item. The image processor is configured to receive the captured image data. The image processor is configured, in response to recognising a predetermined object indicative of the presence of the item in the first representation, to generate image data corresponding to a second, different representation of the scene. A part of the scene that is associated with the item in the first representation is represented differently in the first and second representations. The image processor is configured to output the generated image data.

Abstract: In one aspect, the present disclosure relates to a method which, in one example embodiment, can include reading text data corresponding to messages and creating semantic annotations to the text data to generate annotated messages. Creating the semantic annotations can include generating, at least in part by at least one trained statistical language model, predictive labels as annotations corresponding to language patterns associated with the text data. The method further includes aggregating the annotated messages and storing information associated with the aggregated annotated messages in a message store, and performing, based on information from the message store and associated with the messages, global analytics functions.

Abstract: A method of forming an integrated circuit can include forming a heterostructure over a substrate structure, wherein the given substrate structure comprises a given semiconductor material. The method can include etching a castellated channel region in an e-mode device area of the heterostructure that defines a plurality of ridge channels interleaved between a plurality of trenches, the ridge channels comprising another semiconductor material. The method can also include forming an isolation region on the heterostructure to electrically isolate the e-mode device area from a d-mode device area of the heterostructure. The method can further include forming a mask with an opening that defines a castellated gate opening overlying the castellated channel region and the mask defines an opening overlaying a single planar gate overlying the d-mode device area of the heterostructure. The method can also include performing a contact fill with conductive material to form a castellated gate contact.

Abstract: An unmanned aerial vehicle, UAV, includes (i) a camera having a field of vision including, in use, a portion of a vehicle to be cleaned, (ii) a liquid container comprising waterless carwash liquid, (iii) a liquid dispenser operable to cause the waterless carwash liquid comprised in the liquid container to be dispensed from the liquid container, (iv) a cleaning implement, and (v) a controller communicatively coupled to the camera, the liquid dispenser and the cleaning implement. The controller is operable (a) to cause the liquid dispenser to dispense the waterless carwash liquid from the liquid container onto the portion of the vehicle to be cleaned and (b) to control the cleaning implement to clean the portion of the vehicle to be cleaned.

Abstract: The present disclosure may include, for example, a tunable capacitor having a decoder for generating a plurality of control signals, and an array of tunable switched capacitors comprising a plurality of fixed capacitors coupled to a plurality of switches. The plurality of switches can be controlled by the plurality of control signals to manage a tunable range of reactance of the array of tunable switched capacitors. Additionally, the array of tunable switched capacitors is adapted to have non-uniform quality (Q) factors. Additional embodiments are disclosed.

Abstract: A handheld computing device comprises: a display; a camera operable to capture image data representing a scene, the scene comprising a UAV; an RF receiver configured to receive identification data wirelessly from the UAV as a result of the UAV having broadcast the identification data; and a controller configured to cause the received identification data and/or data based on the received identification data to be displayed on the display at the same time as a representation of the UAV.

Abstract: A system can obtain an operational metric associated with the transceiver, determine a target figure of merit based on a compromise between a desired transmitter performance and a desired receiver, determine a current figure of merit based on the operational metric, and adjust the variable reactance component of the impedance matching circuit based on a comparison of the current figure of merit with the target figure of merit. Other embodiments are disclosed.