Abstract: The present invention provides compounds I and II and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present invention provides a method for inhibiting Hsp70 activity. In some embodiments, the present invention provides a method of treating a subject suffering from or susceptible to a disease, disorder, or condition responsive to Hsp70 inhibition comprising administering to the subject a therapeutically effective amount of a provided compound. In some embodiments, the present invention provides a method for treating or preventing cancer in a subject suffering therefrom, comprising administering to a patient in need thereof a therapeutically effective amount of a provided compound.

Abstract: The present disclosure in various embodiments teaches methods of treating patients in need of treatment with a Factor Xa inhibitor, and who are also concomitantly administered verapamil.

Abstract: The present invention provides compounds I and II and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present invention provides a method for inhibiting Hsp70 activity. In some embodiments, the present invention provides a method of treating a subject suffering from or susceptible to a disease, disorder, or condition responsive to Hsp70 inhibition comprising administering to the subject a therapeutically effective amount of a provided compound. In some embodiments, the present invention provides a method for treating or preventing cancer in a subject suffering therefrom, comprising administering to a patient in need thereof a therapeutically effective amount of a provided compound.

Abstract: After sending M consecutive DUP ACKs, M generally being three, the TCP receiver generates DUP ACKs every N packets, with N greater than one, with the eventually transmitted DUP ACK containing SACK information. After receiving the third DUP ACK the TCP transmitter uses the positive acknowledgements provided in the SACK information in the TCP header to inflate the congestion window. With the reduced DUP ACKs from the TCP receiver to the TCP transmitter, the impact of TCP DUP ACKs on the data rate from the TCP receiver to the TCP transmitter is substantially reduced.

Abstract: After sending M consecutive DUP ACKs, M generally being three, the TCP receiver generates DUP ACKs every N packets, with N greater than one, with the eventually transmitted DUP ACK containing SACK information. After receiving the third DUP ACK the TCP transmitter uses the positive acknowledgements provided in the SACK information in the TCP header to inflate the congestion window. With the reduced DUP ACKs from the TCP receiver to the TCP transmitter, the impact of TCP DUP ACKs on the data rate from the TCP receiver to the TCP transmitter is substantially reduced.

Abstract: The SACK scoreboard is used in slow recovery and the SACK scoreboard and an application programmed timeout are used to determine the initial CWND in slow recovery. The CWND is calculated so that all packets will be recovered before the application times out. A new socket option is provided for an application to program an application timeout (say APP_TO). This value is used in conjunction with the RTT (round trip time) to determine the initial CWND value to insure completion before timeout. Along with the timeout, the application can also set the mode as “soft,” where the CWND value is set to “1” as conventional but when that packet is ACKed, the CWND value is increased immediately to a modified calculated value to allow timely recovery.

Abstract: The present invention provides adiabatic plug flow reactors suitable for the production of chlorinated and/or fluorinated propene and higher alkenes from the reaction of chlorinated and/or fluorinated alkanes and chlorinated and/or fluorinated alkenes. The reactors comprise one or more designs that minimize the production of by-products at a desired conversion.

Abstract: Novel systems and methods are provided that rapidly separate particles from a liquid. In an embodiment, a small volume of liquid (such as a blood sample, or any other solution with a concentration of particles) is input into a flow device implemented as a unilateral channel. When activated by an acoustic energy source (such as an ultrasound pulse), gas-liquid interfaces naturally occurring between the liquid in the flow device and a plurality of gas-filled cavities that line the channel will oscillate and create stable cavitation streaming within a localized region of the surrounding liquid. These oscillations create micro-vortices that gently remove and trap particles and debris from the liquid and adjacent surfaces. Fluid and particle manipulation can thus be accomplished on a passive, disposable chip that is placed on top of an external acoustic transducer with a coupling medium.

Abstract: After sending M consecutive DUP ACKs, M generally being three, the TCP receiver generates DUP ACKs every N packets, with N greater than one, with the eventually transmitted DUP ACK containing SACK information. After receiving the third DUP ACK the TCP transmitter uses the positive acknowledgements provided in the SACK information in the TCP header to inflate the congestion window. With the reduced DUP ACKs from the TCP receiver to the TCP transmitter, the impact of TCP DUP ACKs on the data rate from the TCP receiver to the TCP transmitter is substantially reduced.

Abstract: When in Fast Recovery, Extended Fast Recovery operation starts a timer on the retransmission of each packet. The time expires in one adjusted round trip time. If there has not been an acknowledgement for the retransmitted packet and the Extended Fast Recovery timer expires, it is assumed that the retransmitted packet was lost and must be retransmitted again. Extended Fast Recovery operation keeps retransmitting the packet, once every adjusted round trip time, until an acknowledgement is received or the slow recovery timer expires. Segment Timing is an addition to Extended Fast Recovery where every sent packet is timed separately from the time of first transmission, not just retransmitted packets.

Abstract: The present invention provides isothermal multitube reactors suitable for the production of chlorinated and/or fluorinated propene and higher alkenes from the reaction of chlorinated and/or fluorinated alkanes and chlorinated and/or fluorinated alkenes. The reactors utilize a feed mixture inlet temperature at least 20° C. different from a desired reaction temperature.

Abstract: The present invention provides isothermal multitube reactors suitable for the production of chlorinated and/or fluorinated propene and higher alkenes from the reaction of chlorinated and/or fluorinated alkanes and chlorinated and/or fluorinated alkenes. The reactors utilize a feed mixture inlet temperature at least 20° C. different from a desired reaction temperature.

Abstract: The present invention provides adiabatic plug flow reactors suitable for the production of chlorinated and/or fluorinated propene and higher alkenes from the reaction of chlorinated and/or fluorinated alkanes and chlorinated and/or fluorinated alkenes. The reactors comprise one or more designs that minimize the production of by-products at a desired conversion.

Abstract: An organic additive is removed from a ceramic honeycomb by an improved method by contacting each end of the extruded honeycomb with a member that has a gas permeability no greater than the outer wall, the member essentially covering the ends and heating the honeycomb to a temperature sufficient to remove the organic additive.