Patents by Inventor Mechthild Rieping

Mechthild Rieping has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050095688
    Abstract: The invention relates to a process for the preparation of L-amino acids, especially L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the family Enterobacteriaceae which produce the desired L-amino acid and in which at least one or more genes selected from the group comprising lpd, aceE and aceF, or nucleotide sequences coding therefor, is (are) enhanced and, in particular, overexpressed, b) enrichment of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the desired L-amino acid.
    Type: Application
    Filed: September 10, 2004
    Publication date: May 5, 2005
    Inventors: Mechthild Rieping, Thomas Hermann, Mike Farwick
  • Publication number: 20050089971
    Abstract: The invention provides a process for the preparation of D-pantothenic acid and/or its salts or animal feed additives containing them by the fermentation of microorganisms of the family Enterobacteriaceae, especially those which already produce D-pantothenic acid, wherein the nucleotide sequence(s) coding for the ytfP and/or yjfA open reading frames (ORF) are attenuated or, in particular, switched off, individually or together, in the microorganisms.
    Type: Application
    Filed: August 22, 2002
    Publication date: April 28, 2005
    Inventor: Mechthild Rieping
  • Publication number: 20050074791
    Abstract: The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.
    Type: Application
    Filed: March 19, 2004
    Publication date: April 7, 2005
    Applicants: Degussa-Huls Aktiengesellachaft, Forschungszentrum Julich GmbH
    Inventors: Caroline Kreutzer, Stephan Hans, Mechthild Rieping, Bettina Mockel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm, Miroslav Patek
  • Publication number: 20050069993
    Abstract: The invention relates to a process for the preparation of L-amino acids, in particular L-threonine.
    Type: Application
    Filed: June 14, 2002
    Publication date: March 31, 2005
    Inventor: Mechthild Rieping
  • Publication number: 20050064561
    Abstract: This invention relates to a process for the production of L-amino acids, in particular L-threonine, in which the following steps are performed: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid, in which at least one or more of the genes, selected from the group iclR and fadR, or nucleotide sequences coding therefor, are enhanced, in particular overexpressed, b) accumulation of the desired L-amino acid in the medium or in the cells of the bacteria and c) isolation of the desired L-amino acid.
    Type: Application
    Filed: September 26, 2002
    Publication date: March 24, 2005
    Applicant: DEGUSSA AG
    Inventors: Mechthild Rieping, Nicole Siebelt
  • Publication number: 20050059124
    Abstract: The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which at least one or more of the genes chosen from the group consisting of sucA and sucB, or nucleotide sequences which code for these, is or are enhanced, in particular over-expressed, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the desired L-amino acid.
    Type: Application
    Filed: July 3, 2002
    Publication date: March 17, 2005
    Inventor: Mechthild Rieping
  • Publication number: 20050054066
    Abstract: The invention relates to a process for the preparation of L-amino acids, in particular L-threonine.
    Type: Application
    Filed: June 14, 2002
    Publication date: March 10, 2005
    Inventor: Mechthild Rieping
  • Publication number: 20050032178
    Abstract: A process for the fermentive preparation of an L-amino acid, in particular L-threonine, comprising: a) fermentation of a microorganism of the Enterobacteriaceae family which produces the desired L-amino acid and in which the rseB gene or nucleotide sequences which code for it is enhanced, in particular, over-expressed, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation or recovery of the desired L-amino acid.
    Type: Application
    Filed: July 10, 2003
    Publication date: February 10, 2005
    Applicant: DEGUSSA AG
    Inventors: Mechthild Rieping, Nicole Siebelt
  • Publication number: 20040259214
    Abstract: A process for the preparation of D-pantothenic acid and/or salts thereof or feedstuffs additives comprising these by fermentation of microorganisms of the Enterobacteriaceae family, in particular those which already produce D-pantothenic acid, in which the nucleotide sequence(s) in the microorganisms which code(s) for the cysK gene is/are enhanced, in particular over-expressed.
    Type: Application
    Filed: June 13, 2002
    Publication date: December 23, 2004
    Applicant: DEGUSSA AG
    Inventors: Thomas Hermann, Birgit Witteck, Mechthild Rieping, Daniela Kruse
  • Publication number: 20040241812
    Abstract: The invention relates to a process for the preparation of L-amino acids, in particular L-threonine.
    Type: Application
    Filed: May 7, 2004
    Publication date: December 2, 2004
    Inventor: Mechthild Rieping
  • Publication number: 20040241813
    Abstract: The invention relates to a process for the preparation of L-amino acids, in particular L-threonine.
    Type: Application
    Filed: December 23, 2003
    Publication date: December 2, 2004
    Inventor: Mechthild Rieping
  • Publication number: 20040241814
    Abstract: The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid and in which at least one or more of the genes chosen from the group consisting of rseA and rseC, or nucleotide sequences which code for these, is or are enhanced, in particular over-expressed, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the desired L-amino acid.
    Type: Application
    Filed: January 20, 2004
    Publication date: December 2, 2004
    Inventor: Mechthild Rieping
  • Publication number: 20040235122
    Abstract: The present invention relates to a process for the production of L-amino acids by fermentation of recombinant microorganisms of the Enterobacteriaceae family, wherein
    Type: Application
    Filed: April 5, 2004
    Publication date: November 25, 2004
    Inventors: Mechthild Rieping, Mike Farwick
  • Publication number: 20040214294
    Abstract: The invention provides a process for the production of L-amino acids, in particular L-threonine, in which the following steps are performed:
    Type: Application
    Filed: March 30, 2004
    Publication date: October 28, 2004
    Inventor: Mechthild Rieping
  • Publication number: 20040191885
    Abstract: The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out:
    Type: Application
    Filed: December 12, 2003
    Publication date: September 30, 2004
    Inventor: Mechthild Rieping
  • Patent number: 6746855
    Abstract: The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.
    Type: Grant
    Filed: January 8, 2003
    Date of Patent: June 8, 2004
    Assignees: Dégussa-Hüls Aktiengesellschaft, Forschungszentrum Jülich GmbH
    Inventors: Caroline Kreutzer, Stephan Hans, Mechthild Rieping, Bettina Mockel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm, Miroslav Patek
  • Publication number: 20040082040
    Abstract: The invention relates to amino acid-producing bacteria from the family Enterobacteriaceae, in particular from the species Escherichia coli, which contain a stop codon chosen from the group amber, ochre and opal in the nucleotide sequence for the coding region of the rpoS gene and a suppressor for a stop codon chosen from the group amber suppressor, ochre suppressor and opal suppressor. This invention also relates to a process for preparing amino acids, in particular L-threonine, using these bacteria.
    Type: Application
    Filed: January 21, 2003
    Publication date: April 29, 2004
    Applicant: Degussa AG
    Inventors: Mechthild Rieping, Nicole Siebelt
  • Patent number: 6727086
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the sigH gene, and a host-vector system having a coryneform host bacterium in which the sigH gene is present in attenuated form and a vector which carries at least the sigH gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: April 27, 2004
    Assignee: Degussa AG
    Inventors: Brigitte Bathe, Indra Schröder, Mechthild Rieping, Achim Marx, Mike Farwick, Walter Pfefferle, Thomas Hermann
  • Patent number: 6689592
    Abstract: A process for the enzymatic production of D-pantothenic acid and/or its salts or feedstuffs additives containing the latter by fermentation of microorganisms of the family Enterobacteriaceae, in particular those that already produce D-pantothenic acid, wherein the nucleotide sequence(s) coding for the serC gene is/are enhanced, in particular overexpressed, in the microorganisms.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: February 10, 2004
    Assignee: Degussa AG
    Inventors: Mechthild Rieping, Thomas Hermann, Walter Pfefferle
  • Patent number: 6686183
    Abstract: A method br the fermentative preparation of D-pantothenic acid and/or its salts or feedstuff additives containing these. Said method comprising fermentation of Escherichia coli microorganisms wherein at least one of the nucleotide sequence(s) coding for the gcvT, gcvH, and gcvP gene is overexpressed.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: February 3, 2004
    Assignee: Degussa AG
    Inventors: Mechthild Rieping, Thomas Hermann