Patents by Inventor Megumi Kawai

Megumi Kawai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unnatural Analogues of Calcitriol and Uses Thereof
    Publication number: 20180327354
    Abstract: Disclosed is a compound of Formula (I) in which R1, R2, R3, R4, R5, R6, X, and a are defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are a pharmaceutical composition comprising a compound or salt thereof of Formula (I) and a method of treating a disease which benefits from the modulation of the vitamin D receptor, such as a bone disorder, cardiovascular disease, a cardiovascular complication associated with renal disease, endothelial dysfunction, hyperparathyroidism, hypocalcemia, an immune disorder, left ventricular hypertrophy, a proliferative disease, proteinuria, renal disease, and thrombosis.
    Type: Application
    Filed: April 9, 2018
    Publication date: November 15, 2018
    Inventor: Megumi Kawai
  • Imidazopyridines as a novel scaffold for multi-targeted kinase inhibition
    Patent number: 9051315
    Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: June 9, 2015
    Assignee: AbbVie Inc.
    Inventors: Nwe Y. Ba-maung, Richard F. Clark, Scott A. Erickson, Steve D. Fidanze, Megumi Kawai, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang
  • Vitamin D Receptor Agonists and Uses Thereof
    Publication number: 20120115824
    Abstract: Disclosed is a compound of Formula (I) in which R1, R2, R3, R4, R5, R6, X, and a are defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are a pharmaceutical composition comprising a compound or salt thereof of Formula (I) and a method of treating a disease which benefits from the modulation of the vitamin D receptor, such as a bone disorder, cardiovascular disease, a cardiovascular complication associated with renal disease, endothelial dysfunction, hyperparathyroidism, hypocalcemia, an immune disorder, left ventricular hypertrophy, a proliferative disease, proteinuria, renal disease, and thrombosis.
    Type: Application
    Filed: April 12, 2010
    Publication date: May 10, 2012
    Applicant: VIDASYM, LLC
    Inventor: Megumi Kawai
  • IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION
    Publication number: 20110124632
    Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Application
    Filed: October 18, 2010
    Publication date: May 26, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Nwe Y. Ba-maung, Richard F. Clark, Scott A. Erickson, Steve D. Fidanze, Megumi Kawai, Robert A. Mantei, George S. Sheppard, Bryan K. Sorensen, Gary T. Wang
  • Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors
    Patent number: 7772231
    Abstract: Compounds of formula (25) that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: August 10, 2010
    Assignee: Abbott Laboratories
    Inventors: George S. Sheppard, Gary T. Wang, Fabio Palazzo, Randy L Bell, Robert A. Mantei, Jieyi Wang, Robert D. Hubbard, Megumi Kawai, Scott A. Erickson, Nwe BaMaung, Steve D. Fidanze
  • Sulfonamides having antiangiogenic and anticancer activity
    Patent number: 7491718
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: February 17, 2009
    Assignee: Abbott Laboratories
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • PROTEIN KINASE INHIBITORS
    Publication number: 20070203143
    Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Application
    Filed: December 28, 2006
    Publication date: August 30, 2007
    Inventors: George Sheppard, Gary Wang, Fabio Palazzo, Randy Bell, Robert Mantei, Jieyi Wang, Robert Hubbard, Megumi Kawai, Scott Erickson, Nwe BaMaung, Steve Fidanze
  • 3-Amino-2-hydroxyalkanoic acids and their prodrugs
    Patent number: 7030262
    Abstract: Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: April 18, 2006
    Assignee: Abbott Laboratories
    Inventors: Nwe Y. BaMaung, Richard A. Craig, Jack Henkin, Megumi Kawai, Xenia B. Searle, George S. Sheppard, Jieyi Wang
  • Hydrazide and alkoxyamide angiogenesis inhibitors
    Patent number: 6887863
    Abstract: Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: May 3, 2005
    Assignee: Abbott Laboratories
    Inventors: Richard A. Craig, Megumi Kawai, Linda M. Lynch, Jyoti R. Patel, George S. Sheppard, Jieyi Wang, Fan Yang, Nwe Ba-Maung, Xenia Beebe Searle
  • Antiangiogenic drug to treat cancer, arthritis and retinopathy
    Patent number: 6849757
    Abstract: Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: February 1, 2005
    Assignee: Abbott Laboratories
    Inventors: Megumi Kawai, Jack Henkin, George S. Sheppard, Richard A. Craig
  • Hydrazide and alkoxyamide angiogenesis inhibitors
    Publication number: 20040167126
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: February 19, 2004
    Publication date: August 26, 2004
    Inventors: Richard A. Craig, Megumi Kawai, Linda M. Lynch, Jyoti R. Patel, George S. Sheppard, Jieyi Wang, Fan Yang, Nwe Ba-Maung, Xenia Beebe Searle
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040167128
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: October 8, 2003
    Publication date: August 26, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040157836
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: September 23, 2003
    Publication date: August 12, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
  • 3-Amino-2-hydroxyalkanoic acids and their prodrugs
    Publication number: 20040122098
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: August 6, 2003
    Publication date: June 24, 2004
    Inventors: Nwe Y. BaMaung, Richard A. Craig, Jack Henkin, Megumi Kawai, Xenia B. Searle, George S. Sheppard, Jieyi Wang
  • Antiangiogenic drug to treat cancer, arthritis and retinopathy
    Publication number: 20040110959
    Abstract: Compounds having Formula I 1
    Type: Application
    Filed: July 10, 2003
    Publication date: June 10, 2004
    Inventors: Megumi Kawai, Jack Henkin, George S. Sheppard, Richard A. Craig
  • Sulfonamides having antiangiogenic and anticancer activity
    Publication number: 20040068012
    Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
    Type: Application
    Filed: October 8, 2002
    Publication date: April 8, 2004
    Inventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki Hwan Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang
  • Antiangiogenic drug to treat cancer, arthritis and retinopathy
    Patent number: 6632961
    Abstract: Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: October 14, 2003
    Assignee: Abbott Laboratories
    Inventors: Megumi Kawai, Jack Henkin, George S. Sheppard, Richard A. Craig
  • 3-substituted indole antiproliferative angiogenesis inhibitors
    Publication number: 20020091148
    Abstract: 3-Substituted indole carbohydrazides having the formula 1
    Type: Application
    Filed: September 14, 2001
    Publication date: July 11, 2002
    Inventors: Nwe Y. BaMaung, Richard A. Craig, Megumi Kawai, Jieyi Wang, Yujia Dai, Yan Guo, George Sheppard, Mary K. Verzal, Anil Vasudevan, Michael Michaelides
  • Hydrazide and alkoxyamide angiogenesis inhibitors
    Publication number: 20020002152
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: April 12, 2001
    Publication date: January 3, 2002
    Inventors: Richard A. Craig, Megumi Kawai, Linda M. Lynch, Jyoti R. Patel, George S. Sheppard, Jieyi Wang, Fan Yang, Nwe Ba-Maung
  • 3-substituted indole angiogenesis inhibitors
    Patent number: 6323228
    Abstract: 3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: November 27, 2001
    Assignee: Abbott Laboratories
    Inventors: Nwe Y. BaMaung, Richard A. Craig, Megumi Kawai, Jieyi Wang