Patents by Inventor Megumi Kawai

Megumi Kawai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted &bgr;-amino acid inhibitors of methionine aminopeptidase-2
    Patent number: 6242494
    Abstract: A class of substituted b-amino acids are potent inhibitor of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: June 5, 2001
    Assignee: Abbott Laboratories
    Inventors: Richard A. Craig, Jack Henkin, Megumi Kawai, Linda M. Lynch, Jyoti Patel, George S. Sheppard, Jieyi Wang
  • Sulfamate containing macrocyclic immunomodulators
    Patent number: 6121257
    Abstract: The present invention relates to novel compounds of formula I: ##STR1## which are useful as immunomodulators, in particular, macrolide immunosuppressants. The invention also relates to the preparation of compounds of formula I, compositions containing such compounds, and methods of using such compounds.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: September 19, 2000
    Assignee: Abbott Laboratories
    Inventors: Megumi Kawai, Indrani W. Gunawardana
  • Method for adjusting engaged clearance between rotors of screw compressor and apparatus therefor
    Patent number: 5910001
    Abstract: A method of adjusting the engaged clearance between rotors of a screw compressor which has a male rotor and a female rotor inside a casing, both of the rotors being rotated while maintaining a required very small clearance using timing gears fixed individually to the rotors through shrink fitting, wherein the very small clearance between the rotors is set to a required value by loosening the shrink fitting between one of the timing gears and the rotor on which the one of the timing gears is mounted, while movement of the other of the timing gears is being restricted; and intermittently applying torques to the rotor on which the one of the timing gears is mounted using a servo motor. In this way, it is possible to obtain a screw compressor in which a very small clearance between the rotors can be set to a required value in a short time, and in which high reliability in the symmetrizing adjustment and a high compressing performance can be obtained.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: June 8, 1999
    Assignee: Hitachi Techno Engineering Co., Ltd.
    Inventors: Kenichi Takahashi, Hiroyuki Matsuno, Hiroyasu Obata, Megumi Kawai
  • Macrocyclic immunomodulators
    Patent number: 5708002
    Abstract: Immunomodulatory macrocyclic compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is selected from one of the formulae ##STR2## as well as pharmaceutical compositions containing the same.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: January 13, 1998
    Assignee: Abbott Laboratories
    Inventors: Jay R. Luly, Megumi Kawai, Yat Sun Or, Paul Wiedeman, Rolf Wagner
  • Macrocyclic immunomodulators
    Patent number: 5604294
    Abstract: Immunomodulatory macrocyclic compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein Y is selected from one of the formulae ##STR2## as well as pharmaceutical compositions containing the same and methods of their use.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: February 18, 1997
    Inventors: Jay R. Luly, Megumi Kawai, Yat S. Or, Paul E. Wiedeman, Rolf Wagner
  • Substituted alicyclic amine-containing macrocyclic immunomodulators
    Patent number: 5561140
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R.sup.104 and R.sup.105 is hydrogen, and the other of R.sup.104 and R.sup.105 is a group having the formula ##STR2## as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: October 1, 1996
    Assignee: Abbott Laboratories
    Inventors: Megumi Kawai, Jay R. Luly
  • Macrocyclic immunomodulators
    Patent number: 5561228
    Abstract: Immunomodulatory macrocyclic compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is a group having the formula ##STR2## as well as pharmaceutical compositions containing the same.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: October 1, 1996
    Assignee: Abbott Laboratories
    Inventors: Yat S. Or, Jay R. Luly, Megumi Kawai, Rolf Wagner, Paul E. Wiedeman
  • Substituted alicyclic-aliphatic amine-containing macrocyclic immunomodulators
    Patent number: 5561139
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R.sup.104 and R.sup.105 is hydrogen, and the other of R.sup.104 and R.sup.105 is a radical having the formula ##STR2## as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: October 1, 1996
    Assignee: Abbott Laboratories
    Inventors: Jay R. Luly, Megumi Kawai
  • Heterocycle-containing macrocyclic immunomodulators
    Patent number: 5541193
    Abstract: Immunomodulatory macrocyclic compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R.sup.107, R.sup.108, R.sup.109 and R.sup.110 is a radical having the formula ##STR2## as well as pharmaceutically compositions containing such compounds and methods of immunomodulatory therapy utilizing the same.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 30, 1996
    Assignee: Abbott Laboratories
    Inventors: Megumi Kawai, Yat S. Or, Jay R. Luly
  • Substituted aliphatic amine-containing macrocyclic immunomodulators
    Patent number: 5541189
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R.sup.104 and R.sup.105 is hydrogen, and the other of R.sup.104 and R.sup.105 is a radical having the formula ##STR2## as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: July 30, 1996
    Assignee: Abbott Laboratories
    Inventors: Jay R. Luly, Megumi Kawai
  • Substituted alicyclic amine-containing macrocyclic immunomodulators
    Patent number: 5530119
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R.sup.104 and R.sup.105 is hydrogen, and the other of R.sup.104 and R.sup.105 is a group having the formula ##STR2## as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: June 25, 1996
    Assignee: Abbott Laboratories
    Inventors: Megumi Kawai, Jay R. Luly
  • Substituted alicyclic aliphatic-amine containing macrocyclic immunomodulators
    Patent number: 5530120
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R.sup.104 and R.sup.105 is hydrogen, and the other of R.sup.104 and R.sup.105 is a radical having the formula ##STR2## as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: June 25, 1996
    Assignee: Abbott Laboratories
    Inventors: Jay R. Luly, Megumi Kawai
  • Substituted aliphatic amine-containing macrocyclic immunomodulators
    Patent number: 5457194
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R.sup.104 and R.sup.105 is hydrogen, and the other of R.sup.104 and R.sup.105 is a radical having the formula ##STR2## as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.
    Type: Grant
    Filed: July 30, 1993
    Date of Patent: October 10, 1995
    Assignee: Abbott Laboratories
    Inventors: Jay R. Luly, Megumi Kawai
  • Macrocyclic immunomodulators
    Patent number: 5457111
    Abstract: Immunomodulatory macrocyclic compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is selected from one of the formulae ##STR2## as well as pharmaceutical compositions containing the same.
    Type: Grant
    Filed: November 9, 1993
    Date of Patent: October 10, 1995
    Assignee: Abbott Laboratories
    Inventors: Jay R. Luly, Megumi Kawai, Yat S. Or, Paul Wiedeman, Rolf Wagner
  • Hexa- and heptapeptide anaphylatoxin-receptor ligands
    Patent number: 5387671
    Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states.Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.
    Type: Grant
    Filed: December 27, 1990
    Date of Patent: February 7, 1995
    Assignee: Abbott Laboratories
    Inventors: Megumi Kawai, Paul Wiedeman, Jay R. Luly, Yat S. Or
  • Hexapeptide anaphylatoxin-receptor ligands
    Patent number: 5386011
    Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states.Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.
    Type: Grant
    Filed: December 27, 1990
    Date of Patent: January 31, 1995
    Assignee: Abbott Laboratories
    Inventors: Paul E. Wiedeman, Megumi Kawai, Jay R. Luly, Yat S. Or, Rolf Wagner
  • Anaphylatoxin-receptor ligands
    Patent number: 5223485
    Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q-T are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.
    Type: Grant
    Filed: June 19, 1991
    Date of Patent: June 29, 1993
    Assignee: Abbott Laboratories
    Inventors: Megumi Kawai, Yat S. Or, Paul E. Wiedeman, Jay R. Luly, Mikel P. Moyer
  • Terminally modified tri-, tetra- and pentapeptide anaphylatoxin receptor ligands
    Patent number: 5190922
    Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.
    Type: Grant
    Filed: June 4, 1991
    Date of Patent: March 2, 1993
    Assignee: Abbott Laboratories
    Inventors: Jay R. Luly, Megumi Kawai, Paul E. Wiedeman