Abstract: Provided herein are compounds of Formula I, or a pharmaceutically acceptable salt thereof: which are useful as PARP inhibitors, as well as pharmaceutical compositions comprising them and methods for their use in treating disorders.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: A computer-implemented expertise mining system is configured to update an expertise database based on a recommender's out of office and/or auto-reply settings for a communication application, such as an email application or social media application. The expertise system obtains the recommender's auto-reply settings directly from the communication application. The auto-reply settings include message body text for out of office and auto-reply messages. The expertise system then extracts recommendation data from the auto-reply settings; and updates an expertise database based on the recommendation data extracted from the auto-reply settings.

Abstract: To evaluate a network's performance in processing communications related to a target transaction, a set of “reference” communications corresponding to the target transaction are compared to a larger set of communications in the network in a “production” environment, to identify the occurrence of the target transaction in the production environment. Preferably, the reference communications are recorded in a laboratory environment that models the production environment, or recorded from the production environment during a period of minimal other activities. A variety of filters are used to eliminate communications in the production environment that are apparently unrelated to the target transaction, including filters based on the time-order of communications among the nodes, the size of the packets being communicated, and the content of the communications.

Abstract: Disclosed are various embodiments for an experience service. An experience service determines if a client device requesting a network page is to receive a modified user experience. Transformation code corresponding to the user experience is communicated to the client device. The client device executes the transformation code to modify a rendering of the requested network page.

Abstract: An integrated system for facilitating local treatment in an organ and capable of universally interfacing with other devices and systems is provided. The integrated system comprises an imaging system interface module configured to functionally associate with an imaging system capable of presenting to a user, through a user-interface device, parameters indicating a mode of operation of the imaging system. The imaging system interface module is configured to receive at least one of the parameters, to interpret such parameter and to allow the integrated system to assume a mode of operation according the parameter. The integrated system further comprises a treatment tool interface module, configured to receive and detect a treatment event signal from a portable treatment tool. The treatment event signal indicates a treatment event, thereby allowing establishing a time of the treatment event and thereby establishing a locality of a treatment provided to the organ by the portable treatment tool.

Abstract: Systems and methods are disclosed for calling desired contacts using a standalone smartphone or other portable device, selecting and using contact information from a customer relationship management (CRM) system, and automatically updating the CRM system with the outcome of each conversation. In addition, systems and methods are disclosed for automatically integrating an automated calling system with a customer relationship management system, contact management system, and/or task management system, so that historical information stored concerning past contact activity and automated calling sessions relating to contacts is automatically updated in the customer relationship management system, contact management system, and/or task management system.

Abstract: The present disclosure relates to techniques of configuring a layout of graphical objects for display. In one example process, the device detects a scroll request and determines whether the scroll request meets predetermined criteria. If the scroll request meets the criteria, the device configures the layout of graphical objects that are to be displayed once the display is scrolled so that the graphical objects are arranged on the display differently than the arrangement in which the graphical objects would have been displayed, had the layout not been configured. If the scroll request does not meet the criteria, the device forgoes the configuration of the layout of graphical objects.

Abstract: The present disclosure relates to techniques of configuring a layout of graphical objects for display. In one example process, the device detects a scroll request and determines whether the scroll request meets predetermined criteria. If the scroll request meets the criteria, the device configures the layout of graphical objects that are to be displayed once the display is scrolled so that the graphical objects are arranged on the display differently than the arrangement in which the graphical objects would have been displayed, had the layout not been configured. If the scroll request does not meet the criteria, the device forgoes the configuration of the layout of graphical objects.

Abstract: Systems and methods using Information-invariant Data Transformation (IIDT) in the transfer of files from an un-trusted to a trusted computer system are disclosed. The IIDT alters the data representation of information, without altering the meaning of the information to a degree that is perceptible to a human consumer of that information. The data transformation operations eliminate embedded malware thereby providing secure transfer of files between the un-trusted and trusted computer systems.

Abstract: A system and method for reducing the likelihood of concurrency errors by identifying vulnerable segments of computer code and stalling other virtual machine threads of execution. According to one embodiment of the present invention, the vulnerable segment is identified at runtime, for example in a dynamic translator. According to another embodiment of the present invention, the vulnerable segment is identified ahead of time, for example in a static translator. According to yet another embodiment of the present invention, the vulnerable segment is identified in the binary translator of a virtual machine monitor.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: This invention relates to an inflatable placemat that functions as a portable sanitary eating area for infants, children or adults with special needs. The inflatable placemat comprises a cavity for food serving and can be secured to a tabletop or a non-porous planar surface by suction cups or similar means. The inflatable placemat further comprises a skirt that folds over the edge of the tabletop for sanitary purposes and creates an additional layer of protection between a user and the edge of a tabletop.

Abstract: An alarm system described herein can be used in commercial, public, or governmental buildings and can be activated by any individual when an intruder poses imminent threat; can contain a portable, removable, self-defense mechanism; can notify everyone within the building of the threat; records surveillance video; and can immediately notify police of an intruder posing serious threat to the public. There remains a vital need in public, commercial, residential and governmental buildings for a robust intruder alarm system that protects the public, warns other patrons, notifies the police, and records crime scene information. The embodiments disclosed herein attempt to provide a method and apparatus for protecting people in the presence of a threatening intruder.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.

Abstract: A massage roller comprises a central spinal recess portion, a circular wall portion on each side of the spinal recess portion, and an outer portion extending outwardly from each of the circular wall portions, the outer portion having a first diameter at or near the circular wall portion, and a second diameter remote from the circular wall portion, the second diameter being larger than the first diameter.

Abstract: A computer network is disclosed that includes a first domain and a second domain. The second domain has a higher security classification than the first domain. The computer network also comprises a Temporal Separation Cross Domain Gateway (TSEP-CDG) having a temporal separation hardware interlock. The interlock is configured to physically prevent communication between the first and second domains. It connects with the first domain in a first state to allow the TSEP-CDG to receive data from the first domain. The TSEP-CDG executes an information-invariant data transformation (IIDT) on the received data before it is available to the second domain. The IIDT alters the representation of the data while conveying the same information, disrupting anti-malware present in the received data. The temporal separation hardware interlock is configured for connection with the second domain in a second state to allow the TSEP-CDG to transmit the transformed data to the second domain.

Abstract: A controller implemented on computing equipment may be used to control switches in a network. End hosts and service devices may be coupled to the switches in the network. The controller may generate a virtual network topology of virtual switches and virtual routers. The controller may control the virtual routers and/or virtual switches to perform service insertion. The controller may perform service insertion by controlling the virtual routers and/or virtual switches to redirect network traffic through one or more selected service devices. The controller may determine which network traffic is to be redirected to which service devices based on a service insertion policy that identifies network traffic and services to be performed on the network traffic.

Abstract: A medical attachment for use on the free end of a suction catheter extending into the middle ear of a patient is disclosed. The attachment can be part of a kit of plural attachments, each attachment being configured for accomplishing a different task. Each attachment includes a proximal base portion and an angularly extending distal portion terminating in a working tip. The working tip can be a foam member, a spade shaped member, or a pointed member. The base portion serves to releasably mount the attachment on the free end of the suction catheter. Also disclosed is a specially constructed suction catheter including a tip in the form of a foam member, a spade shaped member, or a pointed tip member.