Abstract: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for robot motion planning using unmanned aerial vehicles (UAVs). One of the methods includes determining that a current plan for performing a particular task with a robot requires modification; in response, generating one or more flight plans for an unmanned aerial vehicle (UAV) based on a robotic operating environment comprising the robot; obtaining, using the UAV in accordance with the one or more flight plans, a new measurement of the robotic operating environment comprising the robot; and generating, based at least on a difference between the new measurement of the robotic operating environment and a previous measurement of the robotic operating environment, a modified plan for performing the particular task with the robot.

Abstract: A guard for a space access device is configured to output air flow through a distal end portion thereof. The guard includes q housing having a proximal end opening, a distal end opening, and a filter portion positioned between the proximal and distal end openings. The filter includes a first plate having a first opening therethrough and a second plate having a second opening therethrough. When the first plate is overlaid in contact with the second plate, this forms an aperture that extends through both the first and second plates.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for a mobile robotic frame system. In some implementations, a mobile robot includes a motorized frame that is configured to travel to a location. The mobile robot includes a positioning assembly coupled to the motorized frame, a robotic arm having a manipulator, and sensors coupled to the motorized frame. A control system is configured to process data from the sensors and, based on the data from the sensors, provide control data to (i) move the motorized frame, (ii) adjust one or more movable components of the positioning assembly, and (ii) move the robotic arm relative to the motorized frame. The one or more movable components and the robotic arm are operable to position the manipulator at any position in a three-dimensional work volume with 6 degrees of freedom while the motorized frame remains at the location.

Abstract: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.

Abstract: Systems, methods, and apparatuses are described for verifying the authenticity of an integrated circuit device. An integrated test apparatus may use quiescent current and/or conducted electromagnetic interference readings to determine if a device under test matches the characteristics of an authenticated device. Deviations from the characteristics of the authenticated device may be indicative of a counterfeit device.

Abstract: A guard for a space access device is configured to output air flow through a distal end portion thereof. The guard includes q housing having a proximal end opening, a distal end opening, and a filter portion positioned between the proximal and distal end openings. The filter includes a first plate having a first opening therethrough and a second plate having a second opening therethrough. When the first plate is overlaid in contact with the second plate, this forms an aperture that extends through both the first and second plates.

Abstract: Systems, methods, and apparatuses are described for verifying the authenticity of an integrated circuit device. An integrated test apparatus may use quiescent current and/or conducted electromagnetic interference readings to determine if a device under test matches the characteristics of an authenticated device. Deviations from the characteristics of the authenticated device may be indicative of a counterfeit device.

Abstract: The apparatus includes a moveable support platform within the container to reduce a distance that items fall into the container when stowed. The support platform is lowered by a movement mechanism as items are placed into the container. The movement mechanism may be a bladder filled with air, a biasing device, a pneumatic device, or a mechanical device. The moveable support may form a bottom portion of the container during transport of the container. In some instances, the movement mechanism may lift items out of the container to empty the container at a destination.

Abstract: Guards for a space access device are configured to be attached to, as well as removed from the space access device by hand, without the need to resort to any tools to perform the attachment or the removal. A distal guard includes at least first and second filters separated by at least one convoluted pathway, and also includes outwardly extending members projecting outwardly from a base of the distal guard. A proximal guard forms at least one convoluted pathway with a cap forming a proximal end of the space access device. A pull tab provides redundancy against failure. The pull tab may be incorporated into the distal guard.

Abstract: A method and/or electrochemical cell for utilising one or more gas diffusion electrodes (GDEs) in an electrochemical cell, the one or more gas diffusion electrodes have a wetting pressure and/or a bubble point exceeding 0.2 bar. The one or more gas diffusion electrodes can be subjected to a pressure differential between a liquid side and a gas side. A pressure on the liquid side of the GDE over the gas side does not exceed the wetting pressure of the GDE during operation (in cases where a liquid electrolyte side has higher pressure), and/or a pressure on the gas side of the GDE over the liquid side, does not exceeds the bubble point of the GDE (in cases where the gas side has the higher pressure).

Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

Abstract: A digital analytics system comprises a data management system including data extraction modules and a data storage system. The data extraction modules extract data from data sources and store the data in storage units. An analytics engine system including analytics engines and interfaces to retrieve data relevant to the analytics engines from the storage units. The analytics engines may perform prescriptive or descriptive analytics on the retrieved data. An applications interface and storage stores applications. The applications may be executed using information generated by the prescriptive or descriptive analytics performed by the analytics engines.

Abstract: A guard configured to form an air flow channel with a space access device and to clear debris therefrom includes a surface configured to interface with an opposing surface of the space access device to form the air flow channel. A connector is configured to attach the guard to the space access device so that the surface and the opposing surface are oriented in predetermined positions to establish the air flow channel. A wiper extends from at least a portion of the surface, the wiper being configured such that upon rotation of the guard relative to the space access device, the wiper contacts and moves the debris.

Abstract: A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.

Abstract: Systems, methods, and apparatuses are described for verifying the authenticity of an integrated circuit device. An integrated test apparatus may use quiescent current and/or conducted electromagnetic interference readings to determine if a device under test matches the characteristics of an authenticated device. Deviations from the characteristics of the authenticated device may be indicative of a counterfeit device.

Abstract: Systems, methods, and apparatuses are described for verifying the authenticity of an integrated circuit device. An integrated test apparatus may use quiescent current and/or conducted electromagnetic interference readings to determine if a device under test matches the characteristics of an authenticated device. Deviations from the characteristics of the authenticated device may be indicative of a counterfeit device.

Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.