Abstract: This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.

Abstract: Compounds of formula (I): wherein: X is a group of formula (B): ?and R1, R2, R4, n, x, y and z are as defined within are described. Processes for their preparation and their use in the treatment of disorders mediated by the neuropeptide Y5 receptor in a warm-blooded animal, such as a human being, are also described.

Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).

Abstract: The use of a compound of formula (I) in the manufacture of a medicament for the treatment, in a warm-blooded animal, of disorders mediated by the neuropeptide Y5 receptor: wherein: R1, R2, R3 and X1-X6 are as defined within or a pharmaceutically acceptable salt, prodrug or solvate thereof, is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described.

Abstract: Spun-bond nonwoven material made of continuous filaments or fibers, whereby the continuous filaments or fibers are multi-component filaments, in particular bi-component filaments, with a low-melting component on the outer surface. The spun-bond nonwoven material is thermally bonded in a calender. The spun-bond nonwoven material has a mass per unit area of more than 40 g/m2.

Abstract: A distraction osteogenesis fixture to be anchored in a bone, including a lower anchor, a translational screw, and an upper anchor. At least a portion of the lower anchor is externally threaded. At least a portion of the lower anchor includes an anti-rotational feature. The lower anchor includes an internal passage. At least a portion of the internal passage is threaded. At least a portion of the translational screw is externally threaded such that the translational screw is receivable by the threaded internal passage of the lower anchor. The upper anchor includes an internal passage for receiving a portion of the lower anchor and has an anti-rotational feature for engaging the anti-rotational feature of the lower anchor. The internal passage of the upper anchor includes a surface for engaging the translational screw. At least a portion of the upper anchor is externally threaded.

Abstract: A distraction osteogenesis fixture to be anchored in a bone, including a lower anchor, a translational screw, and an upper anchor. At least a portion of the lower anchor is externally threaded. At least a portion of the lower anchor includes an anti-rotational feature. The lower anchor includes an internal passage. At least a portion of the internal passage is threaded. At least a portion of the translational screw is externally threaded such that the translational screw is receivable by the threaded internal passage of the lower anchor. The upper anchor includes an internal passage for receiving a portion of the lower anchor and has an anti-rotational feature for engaging the anti-rotational feature of the lower anchor. The internal passage of the upper anchor includes a surface for engaging the translational screw. At least a portion of the upper anchor is externally threaded.

Abstract: A distraction osteogenesis fixture to be anchored in a bone, including a lower anchor, a translational screw, and an upper anchor. At least a portion of the lower anchor is externally threaded. At least a portion of the lower anchor includes an anti-rotational feature. The lower anchor includes an internal passage. At least a portion of the internal passage is threaded. At least a portion of the translational screw is externally threaded such that the translational screw is receivable by the threaded internal passage of the lower anchor. The upper anchor includes an internal passage for receiving a portion of the lower anchor and has an anti-rotational feature for engaging the anti-rotational feature of the lower anchor. The internal passage of the upper anchor includes a surface for engaging the translational screw. At least a portion of the upper anchor is externally threaded.

Abstract: A method of determining at least the concentration of a component from the intensity of electromagnetic waves with at least two selected wavelengths which are reflected by human tissue or transmitted through human tissue comprises firstly the step of converting the intensities of the received electromagnetic signals into at least one first and one second time-dependent electric signal. Then a time-discrete transformation of the first and of the second electric signal into the frequency domain is performed to determine first and second spectral values of the first and of the second signal. Complex combinatorial values are formed from said first and second spectral values and physiologically relevant combinatorial values are selected by evaluating the complex combinatorial values according to given criteria for the physiological relevance thereof. Finally, the concentration of the component is calculated by using the selected combinatorial values or by using the frequencywise-associated spectral values.