Abstract: The present invention relates to an aptamer not binding to the receptor-binding domain of the SARS-CoV-2 spike glycoprotein nor inhibiting the interaction of the receptor-binding domain (RED) of spike glycoprotein with angiotensin-converting enzyme II (ACE2) and/or comprising or consisting of a nucleotide sequence SEQ ID NO: 1, a composition comprising the aptamer, and the use of the aptamer in the detection of SARS-CoV-2 or diagnosis or treatment of a SARS-CoV-2 infection.

Abstract: A method of treating cooling circuit water of industrial plants (2) contaminated with organic substances and inorganic particles, comprises the following steps: a) separating the organic substances and inorganic particles from the cooling circuit water to obtain precleaned cooling circuit water; b) cooling the precleaned cooling circuit water by an open cooling tower (11) to obtain cooled precleaned cooling circuit water; c) desalinating at least a partial volume flow of the cooled precleaned cooling circuit water by an desalination plant (14) to obtain cleaned cooling circuit water; and d) adding bacteria capable of degrading organic substances present in the cooling circuit water. The bacteria are added to the cooling circuit water before the separation in accordance with step a), before the cooling in accordance with step b) and/or before the desalination in accordance with step c), to form a biological cleaning stage.

Abstract: Disclosed herein is a method for the production of isopentenyl diphosphate, dimethylallyl diphosphate and/or isoprenoids derived therefrom.

Abstract: The invention pertains to novel methods to increase the tolerance of microbial host cells to toxic substance, for example terpenes and alcohols and other membrane disrupting substances, as well as modified organism with such an increased tolerance a compared to the unmodified organism.

Abstract: A drain guard for a sink equipped with a garbage disposal, the drain guard having a support ring and at least two interior surfaces extending inward and terminating internal of the support ring. The interior surfaces may have free edges that are laterally proximate but separated by a vertical distance to allow for the passage of food waste but prevent utensils and other objects from entering the garbage disposal.

Abstract: The present disclosure relates to methods for producing human milk oligosaccharide (HMO) core structures using glycosidases from family GH20 hexosaminidases. In particular, the present disclosure provides methods for producing lacto-N-triose II (LNT II) and/or lacto-N-tetraose (LNT) by reacting glucosamine-oxazoline and/or lacto-N-biose-oxazoline with lactose catalysed by an enzyme of the glycoside hydrolase family 20 (GH20) according to the classification of the Carbohydrate-Active-Enzymes (CAZy) database. Specific optimized enzymes are identified to catalyse the reactions.

Abstract: The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.

Abstract: Described herein are methods for the production of ammonium acrylate or salts thereof from acrylonitrile using nitrilase as a catalyst.

Abstract: The invention provides an improved method of isolating the 3-(E)-isomer of an unsaturated carboxylic acid from a mixture of corresponding (E/Z)isomers. More particularly, the present invention relates to an improved method for the biocatalytic preparation of (3E,7E)-homofarnesylic acid; as well as a novel biocatalytic method for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations having an increased content of (3E,7E)-homofarnesol. The present invention also relates to methods of preparing(?)-ambroxby applying (3E,7E)-homofarnesylic acid or (3E,7E)-homofarnesol as obtained according to the invention as starting material.

Abstract: The invention relates to a roll stand (2) for rolling, in particular cold-rolling, metal products, comprising at least one actuator (16) which can be actuated for actively damping vibrations in the roll stand (2), and at least one supporting roll (10) which is non-adjustable or can be adjusted exclusively via a readjusting device for pass line adjustment (13) of the roll stand (2) for supporting a working roll (5) and/or intermediate roll of the roll stand (2), wherein the supporting roll (10) is guided at the ends via a respective bearing unit (11) on a rack (8) of the roll stand (2). In order to enable an optimal active damping of vibrations in a roll stand (2) of this type with low engineering effort, the invention proposes that the supporting roll (10) is supported on the actuator (16) via at least one bearing unit (11) and that the actuator (16) is supported on a section (17) of the rack (8) either directly or indirectly via at least one component (14) of the readjustment device (13).

Abstract: The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.

Abstract: A valve drive includes a transfer arrangement with an intermediate lever arrangement having a first roller element and an intermediate lever, and a drag lever arrangement having a drag lever. The first roller element is connected to a circumferential contour of a camshaft. The intermediate lever includes a second roller element and a working curve connected to the drag lever. A slotted guide is provided for the intermediate lever arrangement which is engaged by a guide roller element. A torsion spring element with first and second ends engages the intermediate lever arrangement. The first end rests on the cylinder housing portion. The second end acts on a counter bearing rigidly connected with the intermediate lever. The first and second roller element axes are arranged to introduce a force into the intermediate lever which presses the guide roller element against the slotted guide and the first roller element against the camshaft.

Abstract: A method for operating a casting/rolling system and to a corresponding system for casting and rolling an endless strand material. The casting/rolling system comprises a strand casting machine and a rolling train arranged downstream of the strand casting machine. The method has the following step: controlling the drive for the rollers of the first roller frame of the rolling train by means of a drive control in response to a target value specification of the pass sequence model. Furthermore, the drive of the at least one strand guiding roller is controlled by a strand guiding roller drive control in response to a target value specification of the strand casting machine drive model.

Abstract: The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.

Abstract: The invention provides an improved method of isolating the 3-(E)-isomer of an unsaturated carboxylic acid from a mixture of corresponding (E/Z)isomers. More particularly, the present invention relates to an improved method for the biocatalytic preparation of (3E,7E)-homofarnesylic acid; as well as a novel biocatalytic method for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations having an increased content of (3E,7E)-homofarnesol. The present invention also relates to methods of preparing(?)-ambroxby applying (3E,7E)-homofarnesylic acid or (3E,7E)-homofarnesol as obtained according to the invention as starting material.

Abstract: The present invention relates to methods of producing sugar phosphates by enzymatic transphosphorylation, wherein the phosphoryl transfer from phosphate donor substrates to sugar substrates is catalyzed by an enzyme having alpha-glucose-1-phosphatase activity. Furthermore, the present invention relates to a biocatalyst having sucrose phosphorylase as well as alpha-glucose-1-phosphatase activity and its use. The production of an enzyme having alpha-glucose-1-phosphatase activity and its use in the transphosphorylation of sugar substrates is also presented herein.

Abstract: The present invention relates to biocatalytic methods, comprising purely enzymatic, mixed enzymatic-fermentative and purely fermentative methods, for the direct single-step conversion of L-fucitol to L-fucose, in order to easily obtain L-fucose at high amounts and levels of purity. Suitable recombinant microorganisms and fungi are further disclosed and also the use thereof in said method for the single-step conversion to L-fucose.

Abstract: An aluminum hot strip rolling mill including a multi-stand tandem finishing rolling train (2), at least one winding reel (8) arranged downstream, in the rolling direction, of the multi-stand tandem finishing rolling train, a cooling section (4) provided in the outlet region of the aluminum hot strip rolling mill, and at least one trimmer (6) paired with the multi-stand tandem finishing rolling train and arranged downstream, in the rolling direction, in the rolling direction, of the multi-stand tandem rolling mill train.

Abstract: The present invention relates to a method for the regioselective hydroformylation of polyunsaturated acyclic hydrocarbons, which are 1, 3 butadienes, which, in the 2 position, bear a saturated or monounsaturated or polyunsaturated acyclic hydrocarbon radical. The present invention also relates to the production of secondary products of these hydroformylation products, especially of ambrox.

Abstract: The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.