Abstract: The present invention relates to probes, methods and apparatus for the detection of the presence or absence of non-contiguous cis-located nucleic acid sequences which are characteristic of alleles including those relating to the human leukocyte antigen (HLA) which is of interest in the field of human transplantation and disease.

Abstract: A method and system for increasing the efficiency of packet processing within a packet protocol handler. In accordance with the method of the present invention packet processing tasks are performed on multiple processors or threads concurrently and in a pipelined fashion. Subsequent protocol packet processing tasks for processing a single packet are performed on multiple processors or threads, acting as stages of a pipeline. The assignment of tasks to processors or threads is performed dynamically, by checking the availability of a processor or thread in the subsequent pipeline stage. The availability determination includes determining the available capacity of the input work queue associated with each processor or thread. If the subsequent pipeline stage is overloaded, the task is assigned to another processor or thread that is not overloaded.

Abstract: The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and removing at least the recombinant MHC molecules to which antibodies to said recombinant MHC molecules contained within the sample have bound. This method allows the depletion of one or more specific MHC particularly HLA allele antibodies from a sample.

Abstract: A method and system for increasing the efficiency of packet processing within a packet protocol handler. In accordance with the method of the present invention packet processing tasks are performed on multiple processors or threads concurrently and in a pipelined fashion. Subsequent protocol packet processing tasks for processing a single packet are performed on multiple processors or threads, acting as stages of a pipeline. The assignment of tasks to processors or threads is performed dynamically, by checking the availability of a processor or thread in the subsequent pipeline stage. The availability determination includes determining the available capacity of the input work queue associated with each processor or thread. If the subsequent pipeline stage is overloaded, the task is assigned to another processor or thread that is not overloaded.

Abstract: The invention provides a method of detecting the presence of anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and detecting the binding or absence of binding of antibodies to said recombinant MHC molecules. This method allows the detection and/or identification of one or more specific MHC particularly HLA allele antibodies.

Abstract: A system implementing a methodology for determining the exponent in parallel with determining the fractional shift during normalization according to partitioning the exponent into partial exponent groups according to the fractional shift data flow, determining all possible partial exponent values for each partial exponent group according to the fractional data flow, and providing the exponent by selectively combining possible partial exponents from each partial exponent group according to the fractional data flow. There is also provided a system implementing a methodology for generating the sticky bit during normalization. Sticky bit information is precalculated and multiplexed according to the fractional dataflow. In an embodiment of the invention, group sticky signals are calculated in tree form, each group sticky having a number of possible sticky bits corresponding to the shift increment amount of the multiplexing.

Abstract: A system implementing a methodology for determining the exponent in parallel with determining the fractional shift during normalization according to partitioning the exponent into partial exponent groups according to the fractional shift data flow, determining all possible partial exponent values for each partial exponent group according to the fractional data flow, and providing the exponent by selectively combining possible partial exponents from each partial exponent group according to the fractional data flow. There is also provided a system implementing a methodology for generating the sticky bit during normalization. Sticky bit information is precalculated and multiplexed according to the fractional dataflow. In an embodiment of the invention, group sticky signals are calculated in tree form, each group sticky having a number of possible sticky bits corresponding to the shift increment amount of the multiplexing.

Abstract: A system implementing a methodology for determining the exponent in parallel with determining the fractional shift during normalization according to partitioning the exponent into partial exponent groups according to the fractional shift data flow, determining all possible partial exponent values for each partial exponent group according to the fractional data flow, and providing the exponent by selectively combining possible partial exponents from each partial exponent group according to the fractional data flow. There is also provided a system implementing a methodology for generating the sticky bit during normalization. Sticky bit information is precalculated and multiplexed according to the fractional dataflow. In an embodiment of the invention, group sticky signals are calculated in tree form, each group sticky having a number of possible sticky bits corresponding to the shift increment amount of the multiplexing.

Abstract: An adder which takes advantage of the early arriving bits of a time skewed operand to provide a result to an add or substract operation without additional latency. Possible partial results are calculated and then selectively combined according to the late arriving data as the late arriving data becomes available. In an embodiment of the present invention, a first operand is partitioned into groups according to the arrival time of the skewed data, and possible partial results for each group are calculated for the full range of partial inputs that affect it. In addition, the high order groups are calculated with and without a borrow (carry) which is propagated from a low order group. Once the delayed partial operands are known and the borrows (carrys) determined the partial results are gated through multiplexers according to the borrows and partial results, and thus the result is provided with a delay similar to the delay in arrival of the skewed operand.