Abstract: Provided herein are compositions and methods for diagnosis and therapy through targeted nano-delivery to injured brain endothelium. In some aspects, the compositions comprise a population of polyester derived nanoparticles, wherein each polyester derived nanoparticle comprises a) a therapeutic agent encapsulated therein for treating traumatically injured, inflamed, diseased, or disrupted endothelial cells, and b) a targeting ligand bound to the nanoparticle, wherein the targeting ligand binds to a biomarker for the injured, inflamed, diseased, or disrupted endothelial cells, are provided. The nanoparticles can be used for targeting difficult-to-reach injury sites, including the blood brain barrier and brain tissue.

Abstract: Disclosed are devices for improving viability of isolated islets or ?-cells and stimulating insulin production from isolated islets or ?-cells and uses thereof for treating type 1 diabetes.

Abstract: A system and method for instantly measuring and updating customer loyalty for one or more brands on a digital world map through utilization of color and digits is disclosed. The system may include a measuring and updating customer loyalty for one or more brands non-transitory storage media. The method may include uploading a measuring and updating customer loyalty for one or more brands non-transitory storage media onto a memory system declaring brand loyalty thereby increasing a brand's indicia color on a digital world map and retracting brand loyalty thereby decreasing the brand's indicia color on the digital world map.

Abstract: A message is received containing a notification of a change to a longterm value. The one or more longterm accounts are updated. After updating the longterm blockchain, one or more transaction accounts are updated by an update amount, the update amount generated based on the change to the one or more longterm accounts such that a total value of all transaction accounts in the transaction blockchain is based on an aggregate measure of all of the longterm accounts in the longterm blockchain.

Abstract: Embodiments described herein provide a method of forming a low-k carbon-doped silicon oxide (CDO) layer having a high hardness by a plasma-enhanced chemical vapor deposition (PECVD) process. The method includes providing a carrier gas at a carrier gas flow rate and a CDO precursor at a precursor flow rate to a process chamber. A radio frequency (RF) power is applied at a power level and a frequency to the CDO precursor. The CDO layer is deposited on a substrate within the process chamber.

Abstract: The present invention features a superporous hydrogel scaffold for corneal regeneration or replacement and a method for producing the same. The superporous hydrogel is composed of a poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) copolymer mixed with collagen. The scaffold can be used as a suturable hybrid corneal implant or keratoprosthesis.

Abstract: A system and method for instantly measuring and updating customer loyalty for one or more brands on a digital world map through utilization of color and digits is disclosed. The system may include a measuring and updating customer loyalty for one or more brands non-transitory storage media. The method may include uploading a measuring and updating customer loyalty for one or more brands non-transitory storage media onto a memory system declaring brand loyalty thereby increasing a brand's indicia color on a digital world map and retracting brand loyalty thereby decreasing the brand's indicia color on the digital world map.

Abstract: Disclosed are scaffolds for regeneration of articular cartilage which are applicable to both the superficial zone and the middle zone of articular cartilage, and a method for manufacturing the same. The scaffolds have sufficient mechanical properties to support the implantation and regeneration of chondrocytes, and allow cells to show high cell viability with a high content of sulfated glycosaminoglycans (GAGs). In addition, being applicable to both the superficial zone and the middle zone of articular cartilage, the scaffolds facilitate cell adhesion and provide biomimetic surface environments that are effective for growing and differentiating stem cells. Therefore, the scaffolds are helpful in regenerating damaged articular cartilage, thus finding applications in stem cell therapy for articular cartilage damage and disease. Also, the application of the scaffolds can be extended to prostheses of the ear and the nose in plastic surgery.

Abstract: The present invention features a hybrid superporous hydrogel scaffold for cornea regeneration and a method for producing the same. The hybrid hydrogel is composed of a superporous poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) copolymer mixed with collagen. The hybrid scaffold can be used as a suturable hybrid corneal implant or keratoprosthesis.

Abstract: The present invention features a hybrid superporous hydrogel scaffold for cornea regeneration and a method for producing the same. The hybrid hydrogel is composed of a superporous hydrogen matrix with collagen and cells embedded within the pores of the matrix.

Abstract: The invention is designed to maximize equipment/asset utilization while managing and limiting over-production and manufacturing. The invention provides a venue for equipment/s owner/lessor to rent/lease out their equipment/s to prospective lessor/renter. Equipment/s or Asset/s ranging from but not limited to automobiles, cranes, boats, planes, jet ski, camper home, timeshare, club memberships, tools, tractors, bulldozers, pavers, trailers, Bikes, Convertibles, Vans, Trucks, etc. The invention allows idle equipment to be put to work thru a third party that will assure smooth transaction. The invention seeks to provide the following services to enable lease/rental agreements between Owner/Lessor and Lessee/Renters: Brokerage, Agency, Insurance, Bond, Escrow, Guarantee, Waivers, Storage, Maintenance, Conflict Arbitration, etc. The invention will allow for Lessor/Owner and Lessee/Renters to book/reserve/lease/rent their Equipment/Assets in an efficient and secure manner.