Abstract: The present invention relates to Factor IX polypeptides conjugated to heparosan (HEP) polymers, methods for the manufacture thereof and uses of such conjugates. The resultant conjugates may be used—for example—in the treatment or prevention of bleeding disorders such as haemophilia B.

Abstract: The present invention relates to FVIII conjugated to heparosan (HEP) polymers, methods for the manufacture thereof and uses of such conjugates. The resultant conjugates may be used in the treatment or prevention of bleeding disorders such as haemophilia.

Abstract: The present invention relates to the conjugation of Factor VII polypeptides with heparosan polymers.

Abstract: An apparatus and method for supplying virgin sealer and reclaim sealer to a sealer applicator. A closed loop path including a first fluid flow path is coupled between a source of virgin sealer and the applicator and includes a recirculation path from the applicator back to the source of virgin material. A reclaim sealer supply is coupled to the first fluid flow path. Valves open and close the virgin sealer supply and the reclaim sealer supply to alternately supply virgin sealer or reclaim sealer to the applicator. Whenever the first fluid flow path contains reclaim sealer, a valve blocks flow to the recirculation path to prevent reclaim sealer from being recirculated into the source of virgin sealer.

Abstract: The present invention relates to a multi-touch display system that supports both multi-touch human input as well as input from a digital pen. The display system has a display panel that is configured to allow human touches along a front surface to be detected and tracked. The display panel also includes a location pattern that preferably covers the viewable areas of the display panel. The location pattern is configured to allow any location within the location pattern to be detected by analyzing a portion of the display pattern that is associated with the particular location. The digital pen is used to “write” on the display panel, wherein such a writing function involves detecting the location where writing occurs and controlling display content that is displayed on the display panel to reflect what is being written.

Abstract: Method and system aspects for mapping tasks to iteratively improve task assignment in a heterogeneous computing (HC) system include identifying a current machine that defines a makespan in the HC system. Further included is the reassigning of at least one task from the current machine to at least one alternate machine in the HC system according to a predefined reassignment constraint. Reassigning also includes reassigning the at least one task when the at least one alternate machine can perform the at least one task in addition to previously assigned work while finishing in less time than the time of the makespan reduced by time required for the task being reassigned.

Abstract: A collaboration system provides enhanced user interface to enable users to interact with electronic devices. In one embodiment, users can add content to a digital system by using a pen that streams coordinates so that input to the digital system may be based on conventional pen and paper handwriting. In another embodiment, a pie-based menu system is used for input to large display area digital devices in which an occluded portion of the pie-based menu system is not used for direct input by the user. The selection of which areas of the pie-based menu system should be omitted from use is adaptive and responsive to whether the user is left-handed or right-handed, and the wrist angle defined by the user's posture. In still another embodiment, an ergonomic open-shaped pie menu system is provided to facilitate selection of options on a digital surface.

Abstract: A control element is provided, in particular for a motor vehicle, including a material through which light can be passed and whish is provided with at least one opaque coating provided with symbols, and having a transparent enamel layer on the coating, wherein nanoparticles are introduced into the enamel layer and the coating and the enamel layer are removed by means of a laser.

Abstract: Provided are a method, system, and article of manufacture for using a resource context to access resources and source data for a transform. A transform receives a request to transform source data and calls a resource context. The resource context initializes a resource object for the transform and acquires associations to source data and resources needed by the transform. The resource context maintains the acquired associations to source data and resources in the resource object for the transform and supplies the associations to the source data and resources to the transform. The transform transforms the source data using the resources to produce output and provides the output to the resource context.

Abstract: The present invention provides methods and systems for a customizable collector application, which automates multiple diagnostic techniques to obtain sets of diagnostic information. The collector application is easily customizable for use by different products, and may reduce the diagnostic information gathering to a single session. This includes gathering all of the required sets of information about a product problem, the hardware environment, the maintenance levels of the operating system environment, and the involved middleware, both local and distributed. In addition, the collector application has a reusable framework designed to have minor external customization for each product that requires its' service. The output of the collector application may be provided in a format, such as XML, that is viewable by another application, such as browser.

Abstract: The present invention relates to a multi-touch display system that supports both multi-touch human input as well as input from a digital pen. The display system has a display panel that is configured to allow human touches along a front surface to be detected and tracked. The display panel also includes a location pattern that preferably covers the viewable areas of the display panel. The location pattern is configured to allow any location within the location pattern to be detected by analyzing a portion of the display pattern that is associated with the particular location. The digital pen is used to “write” on the display panel, wherein such a writing function involves detecting the location where writing occurs and controlling display content that is displayed on the display panel to reflect what is being written.

Abstract: The present invention relates to a multi-touch display system that supports both multi-touch human input as well as input from a digital pen. The display system has a display panel that is configured to allow human touches along a front surface to be detected and tracked. The display panel also includes a location pattern that preferably covers the viewable areas of the display panel. The location pattern is configured to allow any location within the location pattern to be detected by analyzing a portion of the display pattern that is associated with the particular location. The digital pen is used to “write” on the display panel, wherein such a writing function involves detecting the location where writing occurs and controlling display content that is displayed on the display panel to reflect what is being written.

Abstract: A control element is provided, in particular for a motor vehicle, including a material through which light can be passed and whish is provided with at least one opaque coating provided with symbols, and having a transparent enamel layer on the coating, wherein nanoparticles are introduced into the enamel layer and the coating and the enamel layer are removed by means of a laser.

Abstract: The Designated Hitter Pitching Training System (DH) is a silhouette figure of a batter that stands in the batter's box during bullpen sessions for baseball and fastpitch softball pitchers of all ages and skill levels. Constructed of durable polyethylene, the DH comes in three sizes: the Pro (6?2?), Varsity (5?8?) and Youth (5?2?). The DH provides a more realistic, game-like way for pitchers to practice and will improve a pitcher's ability to more consistently throw their pitches in the strike zone, as well as pitch more accurately and confidently to the inside part of the plate with the Inside Pitch Target. All of this will combine to improve game performance. The DH can also be used by pitchers and catchers as part of their practice activities such as throwing to bases, bunt defense, pitchouts, and intentional walks.

Abstract: A method for providing computer services is provided. The method includes receiving deployments of common standards transform services from each of one or more transform service providers, registering each deployment as a transform service provider, receiving a request for a transform service from a customer, matching the requested grid service with a deployment, linking the customer with a provider of the matched registered deployment and the provider performing a transform on data provided by the customer.

Abstract: The present invention provides methods and systems for a customizable collector application, which automates multiple diagnostic techniques to obtain sets of diagnostic information. The collector application is easily customizable for use by different products, and may reduce the diagnostic information gathering to a single session. This includes gathering all of the required sets of information about a product problem, the hardware environment, the maintenance levels of the operating system environment, and the involved middleware, both local and distributed. In addition, the collector application has a reusable framework designed to have minor external customization for each product that requires its' service. The output of the collector application may be provided in a format, such as XML, that is viewable by another application, such as browser.

Abstract: Provided are a method, system, and article of manufacture for using a resource context to access resources and source data for a transform. A transform receives a request to transform source data and calls a resource context. The resource context initializes a resource object for the transform and acquires associations to source data and resources needed by the transform. The resource context maintains the acquired associations to source data and resources in the resource object for the transform and supplies the associations to the source data and resources to the transform. The transform transforms the source data using the resources to produce output and provides the output to the resource context.

Abstract: A flange for a vehicle exhaust system includes a central opening, bolt holes spaced from the central opening, an annular groove spaced from the central opening formed in a first surface of the flange, and an annular protrusion spaced from the central opening formed in a second surface of the flange. The annular groove and the annular protrusion generally have the same configuration taken in a radial cross-section of each.

Abstract: Method and system aspects for mapping tasks to iteratively improve task assignment in a heterogeneous computing (HC) system include identifying a current machine that defines a makespan in the HC system. Further included is the reassigning of at least one task from the current machine to at least one alternate machine in the HC system according to a predefined reassignment constraint. Reassigning also includes reassigning the at least one task when the at least one alternate machine can perform the at least one task in addition to previously assigned work while finishing in less time than the time of the makespan reduced by time required for the task being reassigned.

Abstract: The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.