Abstract: A process for synthesizing 2-methoxymethyl-1,4-benzenediamine, its derivatives of formula (IV) and the salts thereof, which comprises a reductive amination step. The preferred final product is 2-methoxymethyl-1,4-benzenediamine of formula (IV-a). These compounds may be used as primary intermediates in compositions for dyeing keratin fibers.

Abstract: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]aminolacetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

Abstract: A process for synthesizing 2-methoxymethyl-1,4-benzenediamine, its derivatives of formula (IV) and the salts thereof, which comprises a reductive amination step. The preferred final product is 2-methoxymethyl-1,4-benzenediamine of formula (IV-a). These compounds may be used as primary intermediates in compositions for dyeing keratin fibers.

Abstract: The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

Abstract: The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

Abstract: The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

Abstract: The invention provides an installation tool for use with a battery operated drill or a corded electric drill for repetitive installation of caulk-in anchors. The installation tool utilizes the mechanical advantage of a threaded shaft to improve consistency of the holding reliability of the caulk-in anchor and controls the anchor setting process to insure proper installation while reducing installation time. The installation tool does not rely on bottom setting or a hammer strike to set the anchor, but can be set at a depth independent of hole depth. In one embodiment, the tool can be used with a through hole in the substrate and uses a combination of a threaded shaft and a controlled sensing spring to insure a more uniform installation of the anchor within the substrate across the entire length of the sleeve portion of the anchor, along with a visual check of proper setting of the anchor.

Abstract: The present invention provides a process for the efficient assembly of Boc-protected 3-aminohydantoins/thiohydantoins and 3-aminodihydrouracils/dihydrothiouracils via a one-pot solution phase or solid phase synthesis from readily available starting materials.

Abstract: The invention provides an installation tool for use with a battery operated drill or a corded electric drill for repetitive installation of caulk-in anchors. The installation tool utilizes the mechanical advantage of a threaded shaft to improve consistency of the holding reliability of the caulk-in anchor and controls the anchor setting process to insure proper installation while reducing installation time. The installation tool does not rely on bottom setting or a hammer strike to set the anchor, but can be set at a depth independent of hole depth. In one embodiment, the tool can be used with a through hole in the substrate and uses a combination of a threaded shaft and a controlled sensing spring to insure a more uniform installation of the anchor within the substrate across the entire length of the sleeve portion of the anchor, along with a visual check of proper setting of the anchor.

Abstract: A drive tool which does not require any upper-body force from an operator to install a fastener. The drive tool includes a top portion which is engageable with a drive source and a lower portion which is engageable with a fastener. The drive tool includes springs which are configured to urge the lower portion and upper portion of the tool away from each other (i.e. relative movement) and provide that a generally axial force is applied to the fastener engaged with the lower portion of the tool. As a result, the operator does not need to apply any upper-body axial force to the drive tool to install the fastener. Preferably, the lower portion of the drive tool includes one or more foot pads on which an operator may stand, and the spring(s) become compressed when the operator stands on the foot pad(s).

Abstract: An improved anchor device or fastening member which is particularly suited for use in the attachment of various fixtures and equipment to masonry, concrete, and other hard and/or friable substrates includes a head and a shank depending therefrom. The shank has a first threaded portion having a predetermined thread angle and a predetermined hardness, and a second threaded portion having a predetermined thread angle and a predetermined hardness. The first threaded portion is proximate to the head and the second threaded portion extends from the first threaded portion. The thread angle of the first threaded portion is different than the thread angle of the second threaded portion. In addition, the hardness of the first threaded portion is softer than the hardness of the second threaded portion. This provides for a more ductile anchorage when the fastening member is engaged with the substrate.

Abstract: A drive tool which does not require any upper-body force from an operator to install a fastener. The drive tool includes a top portion which is engageable with a drive source and a lower portion which is engageable with a fastener. The drive tool includes springs which are configured to urge the lower portion and upper portion of the tool away from each other (i.e. relative movement) and provide that a generally axial force is applied to the fastener engaged with the lower portion of the tool. As a result, the operator does not need to apply any upper-body axial force to the drive tool to install the fastener. Preferably, the lower portion of the drive tool includes one or more foot pads on which an operator may stand, and the spring(s) become compressed when the operator stands on the foot pad(s).

Abstract: A drive tool having a top portion which is engageable with a drive source and a lower portion engageable with a fastener. The drive tool includes an axial load assist mechanism configured to urge the lower portion and upper portion of the tool away from each other (i.e. relative movement) such that a generally axial force is applied to the fastener engaged with the lower portion of the tool. As a result, the amount of upper body axial force an operator must apply to the drive tool to install the fastener is reduced.

Abstract: A novel process of forming a member, process of forming an extruded and axially twisted member, such as a drill, a fastener, a self-drilling/tapping fastener, and the member formed by the process is disclosed. The process includes the steps of: providing a blank; extruding a predetermined shape along at least a section of the blank, thereby forming at least two first portions and at least two portions on the extruded section; forming a head on the end of the blank to define a head and a shank; and axially twisting at least a section of the first and second portions a predetermined amount. As a result of the twisting step, each first portion forms a spiral along the length of the twisted section and each second portion forms a spiral along the length of the twisted section. The first portions alternate with the second portions and each second portion defines a spiral groove for transporting material along the length of the shank. The resulting member can be threaded along all or a portion of the shank.

Abstract: A compound having structure (1) wherein (a) X is selected from the group consisting of O, S, SO, or SO.sub.2 ; (b) each Y is independently hydrogen or straight, branched or cyclic alkanyl having from 1 to about 4 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms; (c) Z is branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (d) W is O or S; and (e) R is straight, branched or cyclic alkyl or aryl, saturated or mono- or di-unsaturated with double or triple bonds, R having from 1 to about 15 atoms other than hydrogen; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen;(e) W is O or S; and(f) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; and(e) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; and(e) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.Pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pair using such compounds.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;(b) X is selected from the group consisiting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; and(e) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: An improved anchor device or fastening member which is particularly suited for use in the attachment of various fixtures and equipment to masonry, concrete, and other hard and/or friable substrates includes a head and a shank depending therefrom. The shank has a first threaded portion having a predetermined thread angle and a predetermined hardness, and a second threaded portion having a predetermined thread angle and a predetermined hardness. The first threaded portion is proximate to the head and the second threaded portion extends from the first threaded portion. The thread angle of the first threaded portion is different than the thread angle of the second threaded portion. In addition, the hardness of the first threaded portion is softer than the hardness of the second threaded portion. This provides for a more ductile anchorage when the fastening member is engaged with the substrate.