Abstract: The present invention relates to quaternary nitrogen-containing phosphate compounds, and the pharmaceutically-acceptable salts and esters thereof having the general structure: ##STR1## wherein: Z is a saturated, unsaturated, or aromatic, monocyclic or polycyclic carbocycle or monocyclic or polycyclic heterocycle containing one or more heteroatoms selected from O, S, or N;Y is N.sup.+ (R.sup.8).sub.2 or C(R.sup.1).sub.2 and when Y is C(R.sup.1).sub.2, at least one R.sup.2 must be N.sup.+ (R.sup.8).sub.3 ;R.sup.1, R.sup.2, R.sup.5, and R.sup.8 are defined in claim 1, m and n are integers from 0 to 10; m+n is from 0 to 10;R is COOH; PO.sub.3 H.sub.2 ; SO.sub.3 H; or P(O)(OH)R.sub.4, wherein R.sub.4 is substituted or unsubstituted alkyl of 1-8 carbons atoms.The present invention further relates to pharmaceutical compostions containing a safe and effective amount of a compound of the present invention, and pharmaceutically-acceptable excipients.

Abstract: A self-drilling/self-tapping fastener which is suitable for attaching a sprinkler system to a metal supporting structure has a driving head and an integral shank with a threaded portion. Process-hardening and threading of the shank harden the shank to a degree of hardness that retains sufficient ductility for resisting vibration loads. The drill tip at the end of the shank and the lead threads adjacent the drill tip are locally hardened to a relatively high degree of hardness for drilling and tapping the metal support members. A graduated transition zone separates the high-hardness zone from the lower-hardness zone, which allows for a single fastener to exhibit two distinctly different material properties in one fastener. The fastener through this dual process also exhibits two distinct load-carrying capabilities.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen;(e) W is O or S; and(f) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;(b) X is selected from the group consisiting of O, S, SO, or SO.sub.2 ;(c) Y is independently hydrogen or straight, branched or cyclic alkyl or aralkyl having from 1 to about 3 carbon atoms; or the Y's are bonded together to form an alkanyl ring having from 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen;(e) R.sub.1 and R.sub.2 are each independently hydrogen or straight, branched or cyclic alkyl, unsubstituted or substituted, carboxyl, carboxamido, alkoxycarbonyl or alkylcarbonyl; and(f) Het is a heteroaryl group comprising one or more rings containing from about 5 to about 8 atoms in the rings and wherein at least one ring has at least one heteroatom selected from O, N, or S,pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: A compound having the structure: ##STR1## wherein (a) W is --C(X')--NRR' or --NR--C(X')R';(b) X and X' are independently O or S;(c) each Y is independently hydrogen or straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms;(d) Z is unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl or benzyl, Z having from 3 to about 10 atoms other than hydrogen;(e) R and R' are each independently selected from hydrogen, hydroxy straight, branched or substituted alkyl having from 1 to about 6 carbon atoms, and cyclic alkyl having from 3 to about 7 carbon atoms; unsubstituted or substituted aryl, heteroaryl or heterocyclic groups; or R and R' are bonded together to form a ring having from from 3 to about 8 atoms wherein about 1 to about 4 atoms may be heteroatoms;pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3;(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen;(e) R.sub.1 is hydrogen or straight, branched or cyclic alkyl, aryl or C(.dbd.NH)--NHR.sub.4 ; and(f) R.sub.2, R.sub.3, and R.sub.4, are independently hydrogen, straight, branched or cyclic alkyl having from one to 10 carbon atoms, or aryl; R.sub.2 and R.sub.3 can be bonded together to form a ring having 5 or 6 atoms.pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

Abstract: A self-drilling stud particularly suited for use in normal weight or lightweight composite deck system where the use of standard weld studs is inappropriate because of the relatively thin material cross-section of the steel support member. The stud is heat treated to a dual-hardness level so that a portion of the stud is capable of drilling the support member and the decking. The remaining portion of the stud remains relatively ductile so that it can withstand and transfer shear loads imposed by shifting of the concrete slab which overlies the decking to the main support members. The stud is a single piece fastener which includes specially formed annular flanges which enhance interlocking between the stud, the concrete slab and support members.

Abstract: A fastener assembly for anchoring masonry to a wall support stud includes a sealing member releasably seated in a retaining groove. The fastener threads into the support stud and is affixed to a hole in the masonry with a bonding agent. The retaining groove holds the sealing member in place during the installation of the fastener, and a break-off groove enables the fastener to be severed inside the masonry. After the fastener has been severed, the sealing member can be relocated inside the masonry to a pre-determined sealing position, thereby insuring the use of a controlled volume of bonding agent.

Abstract: An improved fastener having a non-circular head with a concave recess providing a datum useful in centering the head relative to a non-circular socket of a driving member is disclosed. The recess may have a frusto-conical wall defining an upper, circular edge or substantially triangular walls defining an upper, non-circular edge. An improved tool useful to drive the improved fastener is also disclosed. In the improved tool, a driving member has a tubular extension with a non-circular socket, and a centering pin is axially movable toward and extended position, in which a convex end of the centering pin fits into the concave recess of the screw head when the socket of the tool extension is axially fitted over the fastener head. The centering pin is biased toward the extended position.