Abstract: The present invention relates to a pharmaceutical composition and a process for the preparation of a tablet containing a growth hormone secretagogue as the active ingredient. The tablet is prepared by forming a powder blend of the active ingredient N-[1(R)-[(1,2-dihydro-1-methanesulfonyl-spiro[3H-indole-3,4'-piperdin]-1'- yl)carbonyl]-2-(phenylmethyl-oxy)ethyl]-2-amino-2-methyl-propanamide, or a pharmaceutically acceptable salt thereof, in particular the methanesulfonate salt, with a binder/diluent, a first diluent, a second diluent, a first portion of a disintegrant, and a lubricant; wet granulating the powder blend with a solution of ethanol/water to form granules; drying the granules to remove the ethanol/water; adding a second portion of a disintegrant; lubricating the granules; and compressing the dried granules into the desired tablet form.

Abstract: Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.

Abstract: Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.

Abstract: Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.

Abstract: A smoke detector that operates on the principle of scattered light is disclosed that has the capability of an operating sensitivity that is tens of times greater than that of smoke detectors presently available. Plural light sources are used, their light rays directed radially toward the center of a cylindrical detector chamber having a mirrored wall that reflects light back toward the chamber's center, thereby to brightly illuminate a central detection zone. Scattered light from smoke in this zone is detectable by a photocell at right angles to the converging multiple light rays. To obtain highly improved stability of the light output that enables ultra-high sensitivity, the light sources are light-emitting diodes in series connection and they are driven by a very stable constant voltage source that also powers the photocell detector. This system gains impressive sensitivity while reducing nuisance alarms that have been a common problem regarding efforts to increase smoke detector sensitivity.