Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: A multi-rank system includes multiple circuit ranks communicating over a common data line to multiple data receivers, each corresponding to one or more of the ranks and each having a corresponding reference voltage generator and clock timing adjustment circuit, such that a rank to communicate on the shared data line is switched without reconfiguring outputs of either the reference voltage generators or the clock timing adjustment circuits.

Abstract: Systems and methods for controlling autonomous vehicle are provided. A method can include obtaining, by a computing system, data indicative of a plurality of objects in a surrounding environment of the autonomous vehicle. The method can further include determining, by the computing system, one or more clusters of the objects based at least in part on the data indicative of the plurality of objects. The method can further include determining, by the computing system, whether to enter an operation mode having one or more limited operational capabilities based at least in part on one or more properties of the one or more clusters. In response to determining that the operation mode is to be entered by the autonomous vehicle, the method can include controlling, by the computing system, the operation of the autonomous vehicle based at least in part on the one or more limited operational capabilities.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: The invention relates to a filter insert for insertion into a filter housing of a fluid filter, comprising a filter material, which is designed to be flowed through by a fluid to be filtered during operation of the fluid filter from a raw side to a pure side of the fluid filter, and to a floatable radio module, which is designed to float on a water quantity located in a water collection area of the fluid filter during operation of the fluid filter.

Abstract: A computer implemented method for identifying substitute products for a target product via a distributor's product management computer system, the method includes: receiving, at a distributor's product management computer system, data representing a target product of interest to a user of the system, wherein the target product is described by a plurality of variable-value attributes associated therewith; processing the received data through a machine-learning-produced algorithm and thereby generating data representing a first set of substitute product candidates for the target product and wherein each substitute product candidate has a corresponding match-score that represents a degree of determined similarity between that substitute product candidate and the target product; transforming the generated data that represents the first set of substitute product candidates into data representing a refined set of substitute product candidates by processing the generated data utilizing a constraint-based algorithm;

Abstract: Disclosed herein are systems, methods, and computer program products for operating a lidar system (LS). The methods comprise: receiving result values (RVs) from photodetectors (the RVs based on operations performed by each photodetector to facilitate measurements associated with a light signal reflected off an object external to LS); combining different sets of RVs to generate super pixels; using super pixels to obtain spatiotemporal coherence metrics; selecting a subset of light pulses or a group of RVs based on the spatiotemporal coherence metrics; and detecting a distance between LS and object based on the selected subset of light pulses or the selected group of RVs. The methods enable variable resolution imaging systems in which the resolution of the pixel can be configured to automatically integrate a variable number of spatial and temporal measurements that belong to the same object to improve detection quality rather than using a fixed number of measurements.

Abstract: Hybrid nanomaterials, methods of making the nanomaterials, and methods of using the nanomaterials to detect hydrogen gas.

Abstract: A product management computer system that can include one or more processors, and a computer-readable medium comprising instructions stored therein, which when executed by the processors, can cause the processors to: receive data representing a target product of interest to a user of the system, wherein the target product is described by a plurality of variable-value attributes associated; process the received data through a machine-learning-produced algorithm and generating data representing a first set of substitute product candidates for the target product and wherein each substitute product candidate has a corresponding match-score that represents a degree of determined similarity between that substitute product candidate and the target product; transform the generated data that represents the first set of substitute product candidates into data representing a refined set of substitute product candidates by processing the generated data utilizing a constraint-based algorithm; and output data representing

Abstract: A differential for a vehicle includes a final drive gear with a final drive gear spline, a differential carrier with a differential carrier spline, and an axially slidable clutch. The axially slidable clutch includes a first clutch spline drivingly engaged with a one of the final drive gear spline or the differential carrier spline and a second clutch spline for selectively drivingly engaging with the other one of the final drive gear spline or the differential carrier spline. In an example embodiment, the differential also includes a pair of side gears, each including an inner spline for drivingly engaging a respective axle shaft, a pair of radially offset spider gears, each drivingly engaged with both of the side gears, and a shaft extending through the pair of radially offset spider gears into the differential carrier.

Abstract: Various bone fixation device embodiments include both a fixation device (such as a screw) and a detachable driver device, with the fixation device having an elongate uncannulated fixation shaft, a sharp distal tip, and a proximal head having a first coupling structure and a proximal flat surface, and the detachable driver device having an elongate driver shaft and a distal head having a second coupling structure and a distal flat surface. Further implementations include a combination device comprising both a detachable driver device and a fixation device, along with related systems and methods. In addition, a stabilization device is provided that can be coupled to a detachable driver device and an attachment device to help maintain the coupling of the driver device and the attachment device and help to maintain the coupling thereof during a procedure.

Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

Abstract: A product management computer system that can include one or more processors, and a computer-readable medium comprising instructions stored therein, which when executed by the processors, can cause the processors to: receive data representing a target product of interest to a user of the system, wherein the target product is described by a plurality of variable-value attributes associated; process the received data through a machine-learning-produced algorithm and generating data representing a first set of substitute product candidates for the target product and wherein each substitute product candidate has a corresponding match-score that represents a degree of determined similarity between that substitute product candidate and the target product; transform the generated data that represents the first set of substitute product candidates into data representing a refined set of substitute product candidates by processing the generated data utilizing a constraint-based algorithm; and output data representing

Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, a pharmaceutical use thereof, and a method for preparing the same. According to the present invention, the novel compounds, optical isomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; internal secretion; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, and chromosomal aberration.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: An inspection apparatus includes a specimen stage configured to retain a specimen, at least three imaging devices arranged in a triangular array positioned above the specimen stage, each of the at least three imaging devices configured to capture an image of the specimen, one or more sets of lights positioned between the specimen stage and the at least three imaging devices, and a control system in communication with the at least three imaging devices.

Abstract: Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Scaffolds are placed into the tubular lumens in order to help maintain the shape, anchor the filling structures in place, and provide improved blood flow transition into and out of the tubular lumens.

Abstract: Fibrous structures comprising spunbond filaments and solid additives and methods for making such fibrous structures are provided.

Abstract: Aspects described herein may relate to a transaction exchange platform using a streaming data platform (SDP) and microservices to process transactions according to review and approval workflows. The transaction exchange platform may receive transactions from origination sources, which may be added to the SDP as transaction objects. Microservices on the transaction exchange platform may interact with the transaction objects based on configured workflows associated with the transactions. Processing on the transaction exchange platform may facilitate clearing and settlement of transactions. Some aspects may provide for dynamic and flexible reconfiguration of workflows and/or microservices. Other aspects may provide for data snapshots and workflow tracking, allowing for monitoring, quality control, and auditability of transactions on the transaction exchange platform.