Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

Abstract: A pharmaceutical composition for use as medicament that inhibits autocrine Human Chorionic Gonadotropin (HCG) production and thus carcinogenesis in adult human cells, the composition comprising at least a first pharmaceutically acceptable carrier and an active agent that is a competitively binding progesterone antagonist binding to steroid receptors of human cells, wherein the composition is provided in units designed for the monthly, semi-annual or annual application of the active agent in annual dosages in the range between 0.1 mg to 10.0 mg per kg of person/body-weight.

Abstract: The invention relates to a windshield wiper device (100) comprising a driving means (110) and a control unit (130) for the driving means (110). An operating characteristic map (140) is provided, in which a maximum torque to be output by the driving means (110) and a minimum rotational speed of the driving means (110) are stored.

Abstract: A pharmaceutical composition for use as medicament that inhibits autocrine Human Chorionic Gonadotropin (HCG) production and thus carcinogenesis in adult human cells, the composition comprising at least a first pharmaceutically acceptable carrier and an active agent that is a competitively binding progesterone antagonist binding to steroid receptors of human cells, wherein the composition is provided in units designed for the monthly, semi-annual or annual application of the active agent in annual dosages in the range between 0.1 mg to 10.0 mg per kg of person/body-weight.

Abstract: A pharmaceutical composition for use as medicament that inhibits inhibits autocrine Human Chorionic Gonadotropin (HCG) production and thus carcinogenesis in adult human cells, the composition comprising at least a first pharmaceutically acceptable carrier and an active agent that is a competitively binding progesterone antagonist binding to steroid receptors of human cells, wherein the composition is provided in units designed for the monthly, semi-annual or annual application of the active agent in annual dosages in the range between 0.1 mg to 10.0 mg per kg of person/body-weight.

Abstract: An apparatus and method for the pre and post processing of radar signals to allow for improved measuring of circular depolarization ratio data in a weather radar. The system uses a phase shifter, which is periodically calibrated to ensure proper polarity, to alter the transmission phase of one channel of a radar transmission output. Reflectivity signals are then processed in accordance with rules dependent upon the transmission phase shift to reliably extract circular depolarization ratio (“CDR”) data from the reflectivity signals. CDR data is used to enhance hydrometer recognition in a weather radar system.

Abstract: A mixer-sparger assembly includes a first body portion, a second body portion, a gasket positioned between the first and second body portions to form a seal between the two body portions, an inlet disposed in the first body portion, a fluid chamber disposed in the first body portion or the second body portion and in fluid communication with the inlet, and an outlet disposed in the first body portion or the second body portion and in fluid communication with the fluid chamber, wherein the first and second body portions are comprised of a material having a density of greater than about 1.0 g/cm3, and a plurality of supports to form a self-standing assembly.

Abstract: An apparatus and method for the pre and post processing of radar signals to allow for improved measuring of circular depolarization ratio data in a weather radar. The system uses a phase shifter, which is periodically calibrated to ensure proper polarity, to alter the transmission phase of one channel of a radar transmission output. Reflectivity signals are then processed in accordance with rules dependent upon the transmission phase shift to reliably extract circular depolarization ratio (“CDR”) data from the reflectivity signals. CDR data is used to enhance hydrometer recognition in a weather radar system.

Abstract: Assembling jig for mounting panel structure elements onto a surface of a CFRP-panel, comprising a base frame on which several positioning boards are transversely attached, which are parallel arranged one to another for supporting the CFRP-panel on an upper mounting surface, wherein the base frame comprises at least one metal bar for coupling the positioning boards consisting of a material having a thermal expansion coefficient which corresponds to the thermal expansion coefficient of the CFRP-material of the panel in order to provide a tolerance compensation system in at least longitudinal direction of the base frame.

Abstract: Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.

Abstract: Systems and methods for chronic disease management are disclosed. In some embodiments, a method includes, at a server having one or more processors and memory storing one or more programs for execution by the one or more processors, obtaining one or more user-specific socio-cognitive vectors corresponding to a first user. The method further includes creating a user-specific engagement model in accordance with the one or more obtained socio-cognitive vectors, and generating a user-specific chronic disease management plan for the first user, in accordance with the user-specific engagement model.

Abstract: A self-guided geosteering assembly having an on-board, automated guidance system that incorporates a detailed subsurface earth model and well path to geosteer the assembly along a formation. While advancing along the formation, the guidance system continually monitors data related to formation characteristics and the formation/tool location, compares the data to the earth model and well path, and adjusts the direction of the assembly accordingly. In addition, the data may be utilized to update the earth model in real-time.

Abstract: A vertebral rod connector includes a first portion configured to engage a fastener construct and define a first longitudinal axis. A second portion is configured to engage a vertebral rod and define a second longitudinal axis disposed transverse to the first longitudinal axis. A flexible linking portion is disposed for connecting the first portion with the second portion. The linking portion has a bifurcated configuration oriented transverse to the first longitudinal axis. Methods of use are disclosed.

Abstract: A pharmaceutical composition for use as medicament that inhibits inhibits autocrine Human Chorionic Gonadotropin (HCG) production and thus carcinogenesis in adult human cells, the composition comprising at least a first pharmaceutically acceptable carrier and an active agent that is a competitively binding progesterone antagonist binding to steroid receptors of human cells, wherein the composition is provided in units designed for the monthly, semi-annual or annual application of the active agent in annual dosages in the range between 0.1 mg to 10.0 mg per kg of person/body-weight.

Abstract: A system for determining if a tire of a vehicle is improperly inflated. The system includes a radar, a wheel speed sensor, and a controller. The radar is configured to emit a signal to detect a reflection of the signal off of an object positioned perpendicular to the vehicle, and to output an indication of a speed of the vehicle. The wheel speed sensor is configured to sense a speed of a wheel of the vehicle. The controller is configured to receive the indication of the speed of the vehicle from the radar, to calculate a speed of the vehicle based on the sensed speed of the wheel, and to determine a tire of the wheel is improperly inflated when the speed of the vehicle calculated using the wheel speed sensor varies by more than a predetermined amount from the speed of the vehicle determined using the radar signal.

Abstract: The present invention is concerned with methods for the de novo sequencing of polypeptides from data obtained from mass spectrometry devices, particularly from (MS)n devices.

Abstract: Skeletal stabilization systems include a base, a longitudinal member, and a retaining member. The base includes an engagement surface with a surface area that is positionable in contact with a bone to atraumatically or traumatically engage the base to the bone. The retaining member engages the base to retain the longitudinal member relative to the base so that the longitudinal member can provide a desired stabilization effect to one or more adjacent bony portions.

Abstract: A process for electrolyzing a material to change at least a portion of the material from a first chemical state to a second chemical state includes placing a known quantity of a first substance into either a mixing chamber or an electrolysis chamber of an integrated electrochemical reactor, placing a known quantity of a second substance into the other chamber free of the first substance; sealing an opening to isolate an internal volume within the reactor; rotating the reactor to form a mixture, rotating the reactor again such that the mixture is transferred to the electrolysis chamber; electrolyzing the mixture in the electrolysis chamber to change at least a portion of the mixture from the first chemical state to the second chemical state; and analyzing the first substance, or analyzing the second substance, or analyzing the first chemical state, or analyzing the second chemical state, or any analytical combinations thereof.

Abstract: The present invention is concerned with methods for the de novo sequencing of polypeptides from data obtained from mass spectrometry devices, particularly from (MS)n devices.

Abstract: The invention relates to compositions and methods for treating an activated B-Cell Diffuse Large B-Cell Lymphoma (ABC-DLBCL). Specifically, the invention relates to treating ABC-DLBCL by administering an NF-?B Essential Modulator (NEMO) Binding Domain (NBD) peptide or a mimetic thereof that inhibits NF-?B activation.