Patents by Inventor Michael R. Ladisch
Michael R. Ladisch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190376110Abstract: Biodynamic imaging (BDI) performs Doppler spectroscopy of intracellular motion in living samples. The present disclosure describes novel methods and systems to perform: 1) BDI of living 3D tissue culture exposed to bacteria; 2) BDI of living biopsies exposed to bacteria; 3) BDI of infected tissues responding to antibiotics. A novel new element is the use of immortalized cancer cells to generate tissues that act as “biosensors” or “reporters” of bacterial infection, for cells as found directly in aqueous samples and cells that have been concentrated through filtration, centrifugation or a combination while maintaining them in a viable form. Pathogenicity is assessed through the spectral Doppler signatures of the changes in tissue dynamics induced by the bacteria.Type: ApplicationFiled: June 7, 2019Publication date: December 12, 2019Applicant: Purdue Research FoundationInventors: Michael R. Ladisch, David D. Nolte, John J. Turek, Eduardo de Aquino Ximenes, Honggu Choi
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Patent number: 10144785Abstract: Described are processes that include the non-enzymatic, hydrolytic liquefaction of lignocellulosic biomass to form digest slurries and heat recovery from such digest slurries. Due to enhanced flow properties of the digest slurries such heat recovery can be efficiently conducted in spiral, plate and frame or other heat exchanger designs, with the recovered heat going to unit operations of the process such as heating incoming pretreatment media for the liquefaction. Processes can also involve additional hydrolytic digestion of some or all of the initial slurry components with enzyme and/or additional heat recovery from the initial slurry by direct contact heat exchange in which a portion of the digest slurry liquids is flashed to vapor and that vapor is condensed onto incoming lignocellulosic biomass to the process. Processes as described can be integrated into ethanol manufacture by fermentation of sugars from the digested compositions.Type: GrantFiled: July 29, 2011Date of Patent: December 4, 2018Assignee: Purdue Research FoundationInventors: Michael R. Ladisch, Nathan Mosier, Youngmi Kim, Justin van Rooyen
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Patent number: 10125454Abstract: Described are methods for pretreating lignocellulosic biomass that comprise thermally conditioning the biomass by flow processing an aqueous slurry of the biomass through an outer passage(s) of one or more heat exchange devices while circulating a heat exchange fluid through an inner passage(s) of the heat exchange device(s). Also described are methods for producing fermentation products, especially ethanol, from the pretreated biomass.Type: GrantFiled: June 26, 2009Date of Patent: November 13, 2018Assignees: Purdue Research Foundation, Bowen Engineering CorporationInventors: Michael R. Ladisch, Brian Stater, Bradley Spindler
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Patent number: 10093951Abstract: Whole corn kernels or particles thereof are enzymatically disassembled. The method can produce a solid starch fraction, a solid pericarp fraction, and a liquid fraction. A high purity starch solids product can be provided suitable for use as a feedstock in other chemical processes.Type: GrantFiled: October 10, 2014Date of Patent: October 9, 2018Assignee: Purdue Research FoundationInventors: Michael R. Ladisch, Youngmi Kim
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Patent number: 9777341Abstract: Described are methods for pretreating lignocellulosic biomass that comprise passing a hot aqueous biomass slurry through a heat exchange passage from an inlet to an outlet and locally regulating pressure in the passage by feed of a pressurized liquid medium to one or more intermediate locations of the passage. Also described are methods for producing ethanol from the pretreated biomass.Type: GrantFiled: June 26, 2009Date of Patent: October 3, 2017Assignees: Purdue Research Foundation, Bowen Engineering CorporationInventors: Michael R. Ladisch, Brian Stater, Bradley Spindler
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Patent number: 9651551Abstract: Described are methods and systems useful in the processing of food samples to detect pathogenic cells in the samples. Embodiments include homogenizing a food sample, digesting solids of the homogenized food sample, and removing lipids from the homogenized food sample. Cells in the sample can then be concentrated using hollow fiber membrane filtration. Regeneration cycles can enable multiple reuses of the hollow fiber membrane filter. Systems and processes herein can be automated, under the control of a computer.Type: GrantFiled: September 26, 2014Date of Patent: May 16, 2017Assignee: Purdue Research FoundationInventors: Michael R. Ladisch, Eduardo Ximenes
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Publication number: 20170022523Abstract: Described are processes for the liquefaction of lignocellulosic biomass under the digestive action of dicarboxylic acid(s). Such digests can exhibit enhanced flowability, reduced volume, and significant biomass conversion to dissolved components, and can in some embodiments be further liquefied by contact with an enzyme. Products resultant of these steps can be used for their sugar content to manufacture biofuels or other products.Type: ApplicationFiled: June 7, 2016Publication date: January 26, 2017Inventors: Michael R. Ladisch, Nathan Mosier, Youngmi Kim
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Patent number: 9359619Abstract: Described are processes for the liquefaction of lignocellulosic biomass under the digestive action of dicarboxylic acid(s). Such digests can exhibit enhanced flowability, reduced volume, and significant biomass conversion to dissolved components, and can in some embodiments be further liquefied by contact with an enzyme. Products resultant of these steps can be used for their sugar content to manufacture biofuels or other products.Type: GrantFiled: January 30, 2013Date of Patent: June 7, 2016Assignee: Purdue Research FoundationInventors: Michael R. Ladisch, Nathan Mosier, Youngmi Kim
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Patent number: 9221733Abstract: Mixtures of ethanol and water are dehydrated using starch pearls to adsorb and remove water. Vapor-phase adsorption equilibrium capacities of cassava starch pellets (tapioca pearls) having different particle sizes are disclosed, and tapioca pearl particles are shown to be surprisingly more effective for dehydrating 88 to 97% w/w feed ethanol than corn grits. The adsorption equilibrium curve and BET surface area measurement show that the adsorption capacity of tapioca pearls is a function of surface area available to water molecules. SEM images demonstrate that the particle architecture required for the adsorption and dehydration properties is that of a core-shell configuration with pre-gel starch acting as a central scaffold holding together other particles to the outer layer of the particle. The outer surface area of the pearls, populated with dry starch granules, is the main factor determining the adsorption capacity of the pearls.Type: GrantFiled: August 14, 2013Date of Patent: December 29, 2015Assignees: Purdue Research Foundation, Archer Daniels Midland CompanyInventors: Youngmi Kim, Richard L. Hendrickson, Nathan Mosier, Michael R. Ladisch, Ahmad K. Hilaly
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Publication number: 20150293094Abstract: Described are methods and systems useful in the processing of food samples to detect pathogenic cells in the samples. Embodiments include homogenizing a food sample, digesting solids of the homogenized food sample, and removing lipids from the homogenized food sample. Cells in the sample can then be concentrated using hollow fiber membrane filtration. Regeneration cycles can enable multiple reuses of the hollow fiber membrane filter. Systems and processes herein can be automated, under the control of a computer.Type: ApplicationFiled: September 26, 2014Publication date: October 15, 2015Inventors: Michael R. Ladisch, Eduardo Ximenes
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Publication number: 20150024471Abstract: Whole corn kernels or particles thereof are enzymatically disassembled. The method can produce a solid starch fraction, a solid pericarp fraction, and a liquid fraction. A high purity starch solids product can be provided suitable for use as a feedstock in other chemical processes.Type: ApplicationFiled: October 10, 2014Publication date: January 22, 2015Inventors: Michael R. Ladisch, Youngmi Kim, Richard L. Hendrickson
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Patent number: 8921648Abstract: Methods for increasing yield of fermentable sugars from plant stover are provided. The methods include using plants homozygous for two brown midrib mutations, bm1 and bm3. The methods also include using plants homozygous for a mutation in a gene that results in reduced cinnamyl alcohol dehydrogenase activity, and a mutation in a gene that results in reduced 5-hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity. The methods also include using transgenic plants that have reduced cinnamyl alcohol dehydrogenase activity and reduced 5-hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity in comparison with wild-type plants.Type: GrantFiled: June 13, 2011Date of Patent: December 30, 2014Assignee: Purdue Research FoundationInventors: Willem Evert Vermerris, Michael R. Ladisch, Nathan S. Mosier
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Patent number: 8790904Abstract: The disclosure describes a process for the conversion of lignocellulosic biomass to ethanol utilizing a dicarboxylic acid such as maleic acid as an enzyme mimic to hydrolyze the hemicellulose and cellulose of the biomass. Controlling the condition of the maleic acid hydrolysis can selectively hydrolyze the hemicellulose giving as a result a liquid portion rich in xylose and a solid portion rich in glucan. The glucan can be further hydrolyzed to produce a glucose containing material. The sugar materials can be fermented to produce ethanol which is recovered. The dicarboxylic acid is then recovered from the residue left after the ethanol is removed from the fermentation material, and the recovered dicarboxylic acid is recycled to the beginning of the process to treat additional lignocellulosic biomass.Type: GrantFiled: April 13, 2012Date of Patent: July 29, 2014Assignees: Purdue Research Foundation, Bowen Engineering CorporationInventors: Nathan Mosier, Michael R. Ladisch, Brian Stater, Bradley Spindler
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Publication number: 20140141480Abstract: Mixtures of ethanol and water are dehydrated using starch pearls to adsorb and remove water. Vapor-phase adsorption equilibrium capacities of cassava starch pellets (tapioca pearls) having different particle sizes are disclosed, and tapioca pearl particles are shown to be surprisingly more effective for dehydrating 88 to 97% w/w feed ethanol than corn grits. The adsorption equilibrium curve and BET surface area measurement show that the adsorption capacity of tapioca pearls is a function of surface area available to water molecules. SEM images demonstrate that the particle architecture required for the adsorption and dehydration properties is that of a core-shell configuration with pre-gel starch acting as a central scaffold holding together other particles to the outer layer of the particle. The outer surface area of the pearls, populated with dry starch granules, is the main factor determining the adsorption capacity of the pearls.Type: ApplicationFiled: August 14, 2013Publication date: May 22, 2014Applicants: Archer Daniels Midland Company, Purdue Research FoundationInventors: Youngmi Kim, Richard L. Hendrickson, Nathan Mosier, Michael R. Ladisch, Ahmad K. Hilaly
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Publication number: 20130330788Abstract: Described are processes for the liquefaction of lignocellulosic biomass under the digestive action of dicarboxylic acid(s). Such digests can exhibit enhanced flowability, reduced volume, and significant biomass conversion to dissolved components, and can in some embodiments be further liquefied by contact with an enzyme. Products resultant of these steps can be used for their sugar content to manufacture biofuels or other products.Type: ApplicationFiled: January 30, 2013Publication date: December 12, 2013Inventors: Michael R. Ladisch, Nathan Mosier, Youngmi Kim
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Publication number: 20120322121Abstract: The disclosure describes a process for the conversion of lignocellulosic biomass to ethanol utilizing a dicarboxylic acid such as maleic acid as an enzyme mimic to hydrolyze the hemicellulose and cellulose of the biomass. Controlling the condition of the maleic acid hydrolysis can selectively hydrolyze the hemicellulose giving as a result a liquid portion rich in xylose and a solid portion rich in glucan. The glucan can be further hydrolyzed to produce a glucose containing material. The sugar materials can be fermented to produce ethanol which is recovered. The dicarboxylic acid is then recovered from the residue left after the ethanol is removed from the fermentation material, and the recovered dicarboxylic acid is recycled to the beginning of the process to treat additional lignocellulosic biomass.Type: ApplicationFiled: April 13, 2012Publication date: December 20, 2012Inventors: Nathan Mosier, Michael R. Ladisch, Brian Stater, Bradley Spindler
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Publication number: 20120315683Abstract: Described are processes for producing a product, such as ethanol, from lignocellulosic biomass, and producing a burnable fuel material from byproducts. The burnable fuel material can be burned on site to produce energy to feed back into the production process.Type: ApplicationFiled: April 13, 2012Publication date: December 13, 2012Inventors: Nathan Mosier, Michael R. Ladisch, Jerry B. Warner
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Publication number: 20120058524Abstract: Methods for increasing yield of fermentable sugars from plant stover are provided. The methods include using plants homozygous for two brown midrib mutations, bm1 and bm3. The methods also include using plants homozygous for a mutation in a gene that results in reduced cinnamyl alcohol dehydrogenase activity, and a mutation in a gene that results in reduced 5-hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity. The methods also include using transgenic plants that have reduced cinnamyl alcohol dehydrogenase activity and reduced 5-hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity in comparison with wild-type plants.Type: ApplicationFiled: June 13, 2011Publication date: March 8, 2012Inventors: Willem Evert Vermerris, Michael R. Ladisch, Nathan S. Mosier
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Publication number: 20110212499Abstract: Described are methods for pretreating lignocellulosic biomass that comprise passing a hot aqueous biomass slurry through a heat exchange passage from an inlet to an outlet and locally regulating pressure in the passage by feed of a pressurized liquid medium to one or more intermediate locations of the passage. Also described are methods for producing ethanol from the pretreated biomass.Type: ApplicationFiled: June 26, 2009Publication date: September 1, 2011Inventors: Michael R. Ladisch, Brian Stater, Bradley Spindler
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Publication number: 20110183379Abstract: Described are methods for pretreating lignocellulosic biomass that comprise thermally conditioning the biomass by flow processing an aqueous slurry of the biomass through an outer passage(s) of one or more heat exchange devices while circulating a heat exchange fluid through an inner passage(s) of the heat exchange device(s). Also described are methods for producing fermentation products, especially ethanol, from the pretreated biomass.Type: ApplicationFiled: June 26, 2009Publication date: July 28, 2011Inventors: Michael R. Ladisch, Brian Stater, Bradley Spindler