Patents by Inventor Michael R. Ladisch
Michael R. Ladisch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7968764Abstract: Methods for increasing yield of fermentable sugars from plant stover are provided. The methods include using plants homozygous for two brown midrib mutations, bm1 and bm3. The methods also include using plants homozygous for a mutation in a gene that results in reduced cinnamyl alcohol dehydrogenase activity, and a mutation in a gene that results in reduced 5 -hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity. The methods also include using transgenic plants that have reduced cinnamyl alcohol dehydrogenase activity and reduced 5 -hydroxyconiferaldehyde/5-hydroxyconiferyl alcohol O-methyltransferase activity in comparison with wild-type plants.Type: GrantFiled: May 2, 2006Date of Patent: June 28, 2011Assignee: Purdue Research FoundationInventors: Willem Evert Vermerris, Michael R. Ladisch, Nathan S. Mosier
-
Patent number: 7566383Abstract: A method and system for recovering heat from a pretreated hot biomass stream is described. The method and system for heat recovery includes a flash cooler connected to a direct contact condenser. A liquid portion of the hot biomass stream flashes into vapors upon the hot biomass stream entering the flash cooler. The flashed vapors are transferred to the direct contact condenser. The flashed vapors and an incoming cold biomass stream subsequently come into contact with each other in the direct contact condenser, thereby causing heat to be transferred from the hot biomass stream to the cold biomass stream. As the heat transfer occurs, the flashed vapors condense onto the surface of the cold biomass.Type: GrantFiled: June 17, 2005Date of Patent: July 28, 2009Assignee: Purdue Research FoundationInventors: Rollo J. Everett, Nathan S. Mosier, Jerry L. Weiland, Gary Welch, Michael R. Ladisch
-
Patent number: 7547526Abstract: Methods and kits for the isolation of organisms. Such methods and kits are particularly useful for concentrating and recovering viable organisms from food material. The recovered organisms are of sufficient number and purity to allow detection using a biochip device.Type: GrantFiled: March 15, 2005Date of Patent: June 16, 2009Assignee: Purdue Research FoundationInventors: Michael R. Ladisch, Xingya Liu, Amanda C. Stewart, Wan-Tzu Chen, Nathan S. Mosier, Thomas Huang, Jeremiah Bwatwa, Richard Hendrickson
-
Patent number: 7410709Abstract: A bio-battery includes a biomolecular energy source, a first electrode and a second electrode. In some configurations, a bio-battery may also include a first cell containing the first electrode and the biomolecular energy source, and a second cell having a reducible substrate and the second electrode. The first cell can be in ionic communication with the second cell, for example by a proton exchange membrane. Various biomolecular energy sources can be used, including proton donor molecules or electrolytically oxidizable molecules. For example, the biomolecular energy source can be selected from the group consisting of Nicotinamide Adenine Dinucleotide (NADH), Nicotinamide Adenine Dinucleotide Phosphate (NADPH) and 5,10-Methylenetetrahydrofolate Reductase (FADH).Type: GrantFiled: June 24, 2004Date of Patent: August 12, 2008Assignee: Purdue Research FoundationInventors: Michael R. Ladisch, Nathan S. Mosier, Eric M. Perkins
-
Patent number: 7306924Abstract: A method for collecting a microbiological substance utilizes a micro fabricated biochip having a collection chamber. A fluid sample containing a microbiological entity of interest is delivered to the collection chamber in the biochip. Then a non-uniform electric field is generated in the collection chamber, to retain the microbiological entity of interest in the collection chamber. The microbiological entity is retained through dielectrophoresis induced by the energization of the electrodes by a periodically applied, alternating current.Type: GrantFiled: June 26, 2002Date of Patent: December 11, 2007Assignee: Purdue Research FoundationInventors: Rafael Gomez, Rashid Bashir, Arun K. Bhunia, Michael R. Ladisch, J. Paul Robinson
-
Patent number: 6716620Abstract: A microscale biosensor for use in the detection of target biological substances including molecules and cells is a microfluidic system with integrated electronics, inlet-outlet ports and interface schemes, high sensitivity detection of pathogen specificity, and processing of biological materials at semiconductor interfaces. A fabrication process includes an all top-side processing for the formation of fluidic channels, planar fluidic interface ports, integrated metal electrodes for impedance measurements, and a glass cover sealing the non-planar topography of the chip using spin-on-glass as an intermediate bonding layer. Detection sensitivity is enhanced by small fluid volumes, use of a low-conductivity buffer, and electrical magnitude or phase measurements over a range of frequencies.Type: GrantFiled: March 26, 2001Date of Patent: April 6, 2004Assignee: Purdue Research FoundationInventors: Rashid Bashir, Rafael Gomez, Michael R. Ladisch
-
Publication number: 20030157587Abstract: A method for collecting a microbiological substance utilizes a microfabricated biochip having a collection chamber. A fluid sample containing a microbiological entity of interest is delivered to the collection chamber in the biochip. Then a non-uniform electric field is generated in the collection chamber, to retain the microbiological entity of interest in the collection chamber. The microbiological entity is retained through dielectrophoresis induced by the energization of the electrodes by a periodically applied, alternating current.Type: ApplicationFiled: June 26, 2002Publication date: August 21, 2003Inventors: Rafael Gomez, Rashid Bashir, Arun K. Bhunia, Michael R. Ladisch, J. Paul Robinson
-
Publication number: 20030036054Abstract: A microscale biosensor for use in the detection of target biological substances including molecules and cells is a microfluidic system with integrated electronics, inlet-outlet ports and interface schemes, high sensitivity detection of pathogen specificity, and processing of biological materials at semiconductor interfaces. A fabrication process includes an all top-side processing for the formation of fluidic channels, planar fluidic interface ports, integrated metal electrodes for impedance measurements, and a glass cover sealing the non-planar topography of the chip using spin-on-glass as an intermediate bonding layer. Detection sensitivity is enhanced by small fluid volumes, use of a low-conductivity buffer, and electrical magnitude or phase measurements over a range of frequencies.Type: ApplicationFiled: June 14, 2002Publication date: February 20, 2003Applicant: Purdue Research FoundationInventors: Michael R. Ladisch, Rashid Bashir, Arun K. Bhunia, Rafael Gomez
-
Publication number: 20010053535Abstract: A microscale biosensor for use in the detection of target biological substances including molecules and cells is a microfluidic system with integrated electronics, inlet-outlet ports and interface schemes, high sensitivity detection of pathogen specificity, and processing of biological materials at semiconductor interfaces. A fabrication process includes an all top-side processing for the formation of fluidic channels, planar fluidic interface ports, integrated metal electrodes for impedance measurements, and a glass cover sealing the non-planar topography of the chip using spin-on-glass as an intermediate bonding layer. Detection sensitivity is enhanced by small fluid volumes, use of a low-conductivity buffer, and electrical magnitude or phase measurements over a range of frequencies.Type: ApplicationFiled: March 26, 2001Publication date: December 20, 2001Applicant: PURDUE RESEARCH FOUNDATIONInventors: Rashid Bashir, Arun K. Bhunia, Rafael Gomez, Michael R. Ladisch, J. Paul Robinson, Ayda Sarikaya
-
Patent number: 5846787Abstract: Disclosed are processes for pretreating cellulosic materials in liquid water by heating the materials in liquid water at a temperature at or above their glass transition temperature but not substantially exceeding 220.degree. C., while maintaining the pH of the reaction medium in a range that avoids substantial autohydrolysis of the cellulosic materials. Such pretreatments minimize chemical changes to the cellulose while leading to physical changes which substantially increase susceptibility to hydrolysis in the presence of cellulase.Type: GrantFiled: July 11, 1994Date of Patent: December 8, 1998Assignee: Purdue Research Foundation Office of Technology TransferInventors: Michael R. Ladisch, Karen L. Kohlman, Paul L. Westgate, Joseph R. Weil, Yiqi Yang
-
Patent number: 4345973Abstract: A method for dehydration and/or enrichment of aqueous alcohol mixtures wherein the mixtures in the vapor state are contacted with a dehydration agent which is composed of cellulose, caboxymethylcellulose, cornmeal, cracked corn, corn cobs, wheat straw, bagasse, starch, hemicellulose, wood chips, other grains, other agricultural residues or mixtures thereof.Type: GrantFiled: August 25, 1980Date of Patent: August 24, 1982Assignee: Purdue Research FoundationInventors: Michael R. Ladisch, George T. Tsao
-
Patent number: 4281063Abstract: A process for treating cellulosic materials to obtain glucose therefrom, which process includes an initial acid or base treatment of the cellulosic materials to remove hemicellulose, followed by a solvent treatment of the solid residue to dissolve the native cellulose contained therein. The dissolved cellulose is separated from the solid lignin-containing residue, whereafter the cellulose is reprecipitated by contacting the solution thereof with water. The reprecipitated cellulose is hydrolyzed to glucose either by acid or enzyme hydrolysis. If desired, the cellulose may be reprecipitated and hydrolyzed in the presence of the lignin-containing solid, the latter being separated from the glucose.Type: GrantFiled: October 3, 1979Date of Patent: July 28, 1981Assignee: Purdue Research FoundationInventors: George T. Tsao, Michael R. Ladisch, Christine M. Ladisch, Teh-An Hsu
-
Patent number: 4265675Abstract: A nontoxic cellulose solvent and process for forming and utilizing the same. The solvent includes a metal chelating agent, a metal compound, an oxygen scavenging stabilizing agent and a caustic swelling agent with the disclosed solvent being prepared in either aqueous or solid form. The solvent is caused to contact cellulosic materials in order to dissolve cellulose therefrom. The dissolved cellulose may be reprecipitated and may then be hydrolyzed by cellulose enzyme or acid to yield glucose with lignin being removed either before or after hydrolysis has occurred.Type: GrantFiled: October 3, 1979Date of Patent: May 5, 1981Assignee: Purdue Research FoundationInventors: George T. Tsao, Bruce E. Dale, Michael R. Ladisch
-
Patent number: 4174976Abstract: A process to yield glucose from cellulose through acid hydrolysis. Cellulose is recovered from cellulosic materials, preferably by pretreating the cellulosic materials by dissolving the cellulosic materials in Cadoxen or a chelating metal caustic swelling solvent and then precipitating the cellulose therefrom. Hydrolysis is accomplished using an acid, preferably dilute sulfuric acid, and the glucose is yielded substantially without side products. Lignin may be removed either before or after hydrolysis.Type: GrantFiled: March 8, 1978Date of Patent: November 20, 1979Assignee: Purdue Research FoundationInventors: George T. Tsao, Michael R. Ladisch, Arindam Bose