Abstract: A folding bicycle trailer that converts between a bicycle trailer mode, a stroller mode, and a folded mode. The trailer has a frame having a first and second side frame assemblies, and a floor assembly. Each side frame assembly has a front wheel and a rear wheel. The front wheels are removed from the frame in the bicycle trailer mode, and are connected to the frame in the stroller and folded modes. A connection arm removably connects to a bicycle in bicycle trailer mode. The connection arm is removable in the stroller and folded modes, but can be connected to the trailer in a second position in those modes. The trailer has a removable push bar for stroller mode. The first and second side frame assemblies remain vertical but move closer to one another in the folded mode.

Abstract: A mold assembly including a spacer positioned or disposed between a back-up plate and a cavity block, the mold assembly, and a method of coupling the back-up plate and the cavity block of the mold assembly using a fastener including the spacer substantially as described above, in order to provide spring-loaded self-adjusting alignment between mating mold inserts.

Abstract: A crossing gate mechanism includes a gate mechanism enclosure defining an interior space, external wires located substantially outside the gate mechanism enclosure, and a terminal board positioned within the interior space of the gate mechanism enclosure. The external wires are connected to the terminal board. The terminal board is coupled to and swingable relative to the gate mechanism enclosure.

Abstract: Methods, systems and apparatus for associating electronic devices together based on received audio commands are described. Methods for associating an audio-controlled device with a physically separate display screen device such that information responses can then be provided in both audio and graphic formats using the two devices in conjunction with each other are described. The audio-controlled device can receive audio commands that can be analyzed to determine the author, which can then be used to further streamline the association operation.

Abstract: An example multi-chamber beverage container includes a first chamber containing a first fluid, a second chamber containing at least one second consumable item different than the first fluid, and a tab attached to a connector. The connector extends through the second chamber. The example multi-chamber beverage container further includes a first seal between the first chamber and the second chamber. The first seal is attached to the connector and is configured to be broken in response to activation of the tab to move the connector such that the first chamber and the second chamber are in fluid communication.

Abstract: Electro-optic (EO) devices having an EO polymer core comprising a first host polymer and a first nonlinear optical chromophore (NLOC); and a cladding comprising a second host polymer and a second NLOC, and methods of preparing the same; wherein the first NLOC has a first bridge covalently bonded to an electron-accepting group and an electron-donating group; wherein the second NLOC has a second bridge covalently bonded to an electron-accepting group and an electron-donating group; and wherein the second bridge is less conjugated than the first bridge such that the cladding has an index of refraction that is less than that of the EO polymer core, and wherein the second NLOC is present in the second host polymer in a concentration such that the cladding has a conductivity equal to or greater than at least 10% of the conductivity of the EO polymer core at a poling temperature.

Abstract: A line launcher includes a launcher body extending along a longitudinal axis between a rear end and a front end. The line launcher further includes a handle, a trigger, and a removable battery. The line launcher further includes a compressed gas charge assembly. The line launcher further includes an elongated barrel coupled to the body at the front end. The line launcher further includes a throwline assembly, the throwline assembly including a projectile and a throwline, the projectile insertable into and ejectable from the elongated barrel.

Abstract: Oil compositions and compositions thereof that can form nanoemulsions or microemulsions are disclosed. Such compositions and compositions thereof can be useful for antimicrobial properties and be used to treat or prevent microbial infections.

Abstract: A system for analyzing fluid flow in unconventional, hydraulically-fractured porous media. In one embodiment, the system comprises a reservoir test sample, wherein the reservoir test sample comprises a core barrel, annular fluid, a synthetic tubing, supporting layers, and a core sample stack, wherein the core sample stack comprises one or more core slots.

Abstract: A method of making a trim article includes the steps of 1) obtaining specified criteria of a target component part comprised of a plurality of materials; 2) processing the specified criteria into a design envelope that includes parameters of the target component part within which the trim article to be created is to be confined, 3) inputting the design envelope into an additive manufacturing device supplied with a single forming material; and 4) forming the trim article using the additive manufacturing device from the single material. The formed trim article includes an outer casing with an interior portion having one or more lattice matrices disposed therein and having varying density profiles to simulate the specified criteria of the target component part. The formed trim article is created as a fully integrated monolithic whole via the additive manufacturing device.

Abstract: The present disclosure relates to controlling drug release in cross-linked poly(valerolactone) based matrices. In one aspect, the compounds or pharmaceutically acceptable salts thereof include a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol (PEG) copolymer. In some embodiments, at least a portion of allylvalerolactone residues within the copolymer are crosslinked with a crosslinker. In some embodiments, the compound has a polydispersity index of less than or equal to 1.5. In one aspect, a method is described herein, comprising: (a) polymerizing valerolactone residues, allylvalerolactone, and polyethylene glycol residues in the presence of a non-metal catalyst via a ring opening polymerization to produce a poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer; (b) crosslinking the poly(valerolactone)-co-poly(allylvalerolactone)-co-polyethylene glycol copolymer with a crosslinker; and (c) loading a drug into the crosslinked copolymer.

Abstract: Stabilized TCR constructs comprising a TCR alpha chain polypeptide having a variable alpha (V?) domain and a constant alpha (C?) domain and a TCR beta chain polypeptide having a variable beta (V?) domain and a constant beta (C?) domain. The TCR constructs are stabilized by the introduction into the C? domain and/or the C? domain of stabilizing mutations such as non-naturally occurring disulfide bonds between the C? domain and the C? domain (an interchain disulfide bond), non-naturally occurring intrachain disulfide bonds, point mutations, loop truncation mutations, and combinations thereof. TCR fusion proteins comprising one or more of the TCR constructs and a scaffold and/or other biologically active moiety are also described.

Abstract: Compositions and methods for the preparation of nanoemulsion from oils are disclosure. These nanoemulsions can be produced without the addition of exogenous surfactants or emulsifiers and can be useful as carriers for active ingredients.

Abstract: The present invention provides a method for the treatment of a patient comprising administering to the patient an initial dose of between about 1 mg and about 150 mg of a MAdCAM antagonist antibody. Biomarkers for assessing a patient's response to anti-MAdCAM treatment are also provided.

Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

Abstract: Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

Abstract: A tip valve and a cook system incorporating same that automatically stops the flow of gas to a burner when tipped over and that automatically resets when disconnected from the fuel canister to allow the flow of gas to resume when righted and reconnected are provided. The tip valve includes a ball bearing freely moveable between a fuel canister actuator pin and a tip seal within a bore having two different diameters at each end thereof. The transition between the two diameters forms a taper that may be continuous forming a smooth tapered bore, or discontinuous formed by at least one counter bore. The automatic resetting is provided without the use of a mechanical pin or member.

Abstract: A computer-implemented system and method for automated traffic flow control using domain name for one or more devices enabled for connectivity over cellular network are disclosed. The computer-implemented method for automated traffic flow control using domain name for one or more devices enabled for connectivity includes receiving device information for the one or more devices; receiving domain name information for at least one domain name that the one or more devices are allowed to access, denied to access or a combination thereof; associating the at least one domain name with one or more internet protocol (IP) addresses; monitoring the at least one domain for change in the one or more IP addresses for that domain; and updating the one or more IP addresses of the domain name if any change in the one or more IP addresses for that domain is found.