Abstract: A superconducting coil device (10) includes: a coil case (20) housing a superconducting coil (30); a superconducting coil (30) housed in the coil case (20); and a resin part (50) formed of a polymer (51) filled in a gap between an inner wall of the coil case (20) and the superconducting coil (30). The resin part (50) is formed of a polymer (51) obtained by polymerizing a polymerizable composition containing a first monomer having a norbornene ring structure.

Abstract: A hot pressed member disclosed herein includes: a base steel sheet; a Fe—Zn—Al—Mg-based alloy coated layer containing an ?-Fe phase and a ? phase and formed on at least one surface of the base steel sheet; and an oxide layer containing Zn, Al, and Mg and formed on the Fe—Zn—Al—Mg-based alloy coated layer, in which a ratio of I?/I? is 0.5 or less when measured by X-ray diffraction using a Co-K? (wavelength: 1.79021 ?) radiation source at an incident angle of 25°, where IF is an intensity of a diffraction peak of (411) plane of the ? phase present in an angular range of 41.5°?2??43.0° and I? is an intensity of a diffraction peak of (110) plane of the ?-Fe phase present in an angular range of 51.0°?2??52.0°, and a sum of Al and Mg concentrations in the oxide layer is 28 atomic % or more.

Abstract: Provided are a compound superior in a cytotoxic action on cancer cells, an action inducing degradation of BET protein in cancer cells, and an inhibitory action on the binding of BET protein and acetylated histone, and useful as an anticancer agent, a BET protein degradation inducer or a BET protein inhibitor. A compound represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.

Abstract: A path generation device is configured to generate a path along which a mobile object is to travel. The device comprises a planner module configured to plan a steering angle and a steering angular velocity for the mobile object to travel from a start position to a goal position by generating first and second isosceles triangles connecting the start position and the goal position based on the start position of the mobile object, a start position traveling direction being a traveling direction of the mobile object at the start position, the goal position of the mobile object, and a goal position traveling direction being a traveling direction of the mobile object at the goal position. The device comprises a curved path applying module configured to apply a first curved path along legs of the first isosceles triangle and apply a second curved path along legs of the second isosceles triangle.

Abstract: The present invention provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

Abstract: Provided is a hot-pressed member that combines both high strength of 1850 MPa or more in TS and excellent delayed fracture resistance. A hot-pressed member comprises: a predetermined chemical composition; a microstructure in which a prior austenite average grain size is 8 ?m or less, a volume fraction of martensite is 95% or more, and a volume fraction of granular carbide of 0.1 ?m or more in grain size is 0.10% to 4.0%; a Ni diffusion region of 2.0 ?m or more in a depth direction in a surface layer; and a tensile strength of 1850 MPa or more.

Abstract: A hot press member includes excellent indentation peel strength which has a tensile strength of 1780 MPa or more. A plating layer has at a surface thereof a 10-point average roughness Rzjis of 25 ?m or less, and a steel sheet contains, in mass %, not less than 0.25% but less than 0.50% of C, 1.5% or less of Si, 1.1-2.4% of Mn, 0.05% or less of P, 0.005% or less of S, 0.01-0.50% of Al, 0.010% or less of N, 0.001-0.020% of Sb, 0.005-0.15% of Nb, and 0.005-0.15% of Ti, the balance being Fe and incidental impurities. The average crystal grain size of prior austenite is 7 ?m or less and the volume proportion of martensite is 90% or more, within 50 ?m in the thickness direction from the surface of the steel sheet excluding the plating layer.

Abstract: A hot-pressed member has a predetermined chemical composition. In the hot-pressed member, a steel sheet has a microstructure in which a prior austenite average grain diameter is 8 ?m or less, and martensite is present in a volume fraction of 95% or greater in a region within 30 ?m of a surface; a Ni diffusion region having a thickness of 0.5 ?m or greater exists in a surface layer; a standard deviation of Vickers hardness values is 35 or less; Mndif (mass %) in a sheet thickness direction ?0.20, where Mndif (mass %) is a degree of Mn segregation; and a tensile strength is 1780 MPa or greater.

Abstract: The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V), and (VI). Some bromodomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.

Abstract: The present invention provides compounds and pharmaceutically compositions thereof. The compounds and compositions are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

Abstract: A heating cooking system includes a cooking device (100), servers (400, 500) for communicating with the cooking device (100) via a communication network and an information terminal (300) for communicating with the servers (400, 500) via the communication network. The servers (400, 500) have a communication tool manager (400) for managing communication tools of the information terminal (300) for users. The cooking device (100) has posting sections for posting information relating to executed cooking menus to the communication tool manager (400) of the servers (400, 500) via the communication network (N).

Abstract: A spot welded member includes a spot weld formed by holding a sheet stack of multiple steel sheets between a pair of electrodes and spot-welding the sheet stack, in which at least one of the multiple steel sheets is a high-strength zinc-based coated steel sheet having a tensile strength of 780 MPa or more, the high-strength zinc-based coated steel sheet having a coating with an Al content of 0.5% or more by mass, and in which the heat shock region of the spot weld outwardly extending from an edge of a corona bond area includes a coated layer including an FeAl alloy layer having an average thickness of 0.3 ?m or more and a zinc-based coated layer having an average thickness of 2.0 ?m or more on the FeAl alloy layer at the interface between the base steel sheet of the high-strength zinc-based coated steel sheet and the coating.

Abstract: A semiconductor light emitting device has: a semiconductor light emitting element; a substrate on which the semiconductor light emitting element is mounted and which includes a substrate bonding surface to which a substrate metal layer having an annular shape is fixed; and a light transmitting cap including a window portion containing glass and transmitting radiation light of the semiconductor light emitting element and a flange having a flange bonding surface to which an annular flange metal layer having a size corresponding to the substrate metal layer is fixed, and sealed and bonded to the substrate with a space housing the semiconductor light emitting element. The flange metal layer contains a first metal layer fixed to the flange and having a difference in the coefficient of linear thermal expansion from the flange within 1×10?6·K?1 and a second metal layer formed on the first metal layer.

Abstract: The present invention provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

Abstract: Provided are a compound superior in a cytotoxic action on cancer cells, an action inducing degradation of BET protein in cancer cells, and an inhibitory action on the binding of BET protein and acetylated histone, and useful as an anticancer agent, a BET protein degradation inducer or a BET protein inhibitor.

Abstract: The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V), and (VI). Some bromodomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.

Abstract: The present invention provides compounds and pharmaceutically compositions thereof. The compounds and compositions are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

Abstract: A cooker with a door includes: a proximity sensor configured to detect presence or absence of an object in proximity to the cooker; and a door opening controller configured to control the door to open and close on a detection signal from the proximity sensor, wherein the door opening controller opens the door when receiving the detection signal from the proximity sensor twice or more within a predetermined time period, the detection signal indicating the presence of the object.

Abstract: This invention is intended to evaluate smut resistance with higher accuracy using a marker associated with sugarcane smut resistance, which consists of a continuous nucleic acid region existing in a region between the nucleotide sequence as shown in SEQ ID NO: 1 and the nucleotide sequence as shown in SEQ ID NO: 6, a region between the nucleotide sequence as shown in SEQ ID NO: 135 and the nucleotide sequence as shown in SEQ ID NO: 143, or a region between the nucleotide sequence as shown in SEQ ID NO: 144 or 145 and the nucleotide sequence as shown in SEQ ID NO: 151 of a sugarcane chromosome.

Abstract: A path generation device is configured to generate a path along which a mobile object is to travel. The device comprises a planner module configured to plan a steering angle and a steering angular velocity for the mobile object to travel from a start position to a goal position by generating first and second isosceles triangles connecting the start position and the goal position based on the start position of the mobile object, a start position traveling direction being a traveling direction of the mobile object at the start position, the goal position of the mobile object, and a goal position traveling direction being a traveling direction of the mobile object at the goal position. The device comprises a curved path applying module configured to apply a first curved path along legs of the first isosceles triangle and apply a second curved path along legs of the second isosceles triangle.