Abstract: The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V) and (VI). Some bromdomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases comprising the inventive compounds, as well as methods of using the inventive compounds.

Abstract: The present invention provides compounds of Formula (II) (e.g., compounds of Formula (I)), and pharmaceutically compositions thereof. Compounds of Formula (II) are believed to be binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

Abstract: A high-strength galvanized steel sheet and a method for producing the steel sheet. The steel sheet has a composition that includes C: 0.030% to 0.250%, Si: 0.01% to 3.00%, Mn: 2.00% to 10.00%, P: 0.001% to 0.100%, S: 0.0001% to 0.0200%, N: 0.0005% to 0.0100%, Ti: 0.005% to 0.200%, on a mass basis, and Fe and inevitable impurities. Additionally, the steel sheet has concentration of solute Mn at a depth of 5 ?m or less from a surface of the steel sheet that is 1.50% by mass or less, and a value obtained by dividing the average mass percentage of Mn in retained austenite by the average mass percentage of Mn in ferrite is 2.0 or more.

Abstract: A stylus support portion moveable in an X direction is arranged separate from a fixed portion. A plate spring has a first end fixated to an end portion of the stylus support portion in an X (+) direction, a second end fixated to the fixed portion, and a principal surface facing the X direction. A plate spring has a first end fixated to an end portion of the stylus support portion in an X (?) direction, a second end fixated to the fixed portion, and a principal surface facing the X direction. A first permanent magnet is provided on the end portion of the stylus support portion in the X (+) direction. A second permanent magnet is provided on the end portion of the stylus support portion in the X (?) direction. A third permanent magnet is provided to the fixed portion so that a magnetic force in the X direction acts on an area between the first permanent magnet and the third permanent magnet.

Abstract: A photoelectric sensor includes the following components. A disturbance detection unit detects a disturbance by comparing a light reception result obtained by a light receiver with a first threshold and with a second threshold for a predetermined period in a state where no light is transmitted by a light transmitter. The second threshold takes a value of a sign opposite to that of the first threshold relative to a no-signal state. A waiting unit waits for the light reception result obtained by the light receiver to become within a range from the first threshold to the second threshold upon detection of a disturbance. A disturbance type determination unit causes detection of a disturbance to be performed again after the waiting. A light transmission instruction unit instructs the light transmitter to transmit light when no disturbance is detected for a predetermined period.

Abstract: A galvannealed steel sheet having a galvanized layer on a surface thereof is provided, having a composition which contains C: 0.10% to 0.35%, Si: 0.3% to 3.0%, Mn: 0.5% to 3.0%, P: 0.001% to 0.10%, Al: 0.01% to 3.00%, and S: 0.200% or less on a mass basis, the remainder being Fe and incidental impurities. The steel sheet has a SiC/SiO2 ratio of more than 0.20, the SiC/SiO2 ratio being a ratio of SiC amount to SiO2 amount at a depth of 1 ?m or less in the steel sheet from an interface between the steel sheet and the galvanized layer, and Fe in the galvanized layer constitutes 8% to 13% by mass.

Abstract: A forklift includes: a fork 22, a moving mechanism configured to move the fork in a first direction; a laser sensor 20 mounted on the fork, configured to scan laser light in a second direction intersecting the first direction, and measure a distance from the laser sensor to a surrounding object based on reflection of the scanned laser light; and a processor configured to generate a three-dimensional range image within an emission range to which the laser light is emitted based on distance data acquired when the laser sensor scans the laser light in the second direction while the moving mechanism moves the fork in the first direction.

Abstract: A non-separable pull-tab is hooked on a hook which is attached to a little finger to hang a beverage can. Thus, various shapes of plates and beverage cans can be held by one hand. In addition, manufacturing cost is reduced and portability is increased by making a size compact. A beverage can holder is comprised of a ring (A), two positioning projections (B) and a hook (C), wherein the ring (A) is attached to a little finger, the two positioning projections (B) sandwich an annular finger, a non-separable pull-tab (D) is hooked on the hook (C) for hanging and holding a beverage can (E).

Abstract: A forklift includes a vehicle body 30, a fork 22 mounted on the vehicle body, a controller configured to adjust a position and an orientation of the vehicle body, a laser sensor 20 configured to measure distance data from the laser sensor to an object existing in a space set forward of the fork, and a control commander configured to, when the distance data measured by the laser sensor includes a load or a pallet 100 to be lifted, generate track data for moving the vehicle body to a loading position of the load or the pallet based on the distance data, and provide a command to the controller using the generated track data.

Abstract: A hot-dip galvanized steel sheet having a good appearance and good adhesion to a coating, the hot-dip galvanized steel sheet having a composition containing, on a mass basis: C: 0.08% or more and less than 0.20%, Si: 0.1% to 3.0%, Mn: 0.5% to 3.0%, P: 0.001% to 0.10%, Al: 0.01% to 3.00%, and S: 0.200% or less, a remainder being Fe and incidental impurities, wherein the hot-dip galvanized steel sheet includes an internal oxidation layer and a decarburized layer, the internal oxidation layer having a thickness of 5 ?m or less, the decarburized layer having a thickness of 20 ?m or less, and 50% or more by area of the internal oxidation layer is composed of a Si oxide containing Fe and/or Mn represented by Fe2XMn2-2XSiOY, wherein X ranges from 0 to 1, and Y is 3 or 4.

Abstract: A disclosed management apparatus that manages communication in a network shared by information processing apparatuses of plural users includes: a memory and a processor coupled to the memory.

Abstract: A photoelectric sensor includes a current division control circuit that sequentially sets a reference voltage for each current divider circuit along one of the arrangement directions of photodiodes so that the reference voltage for the current divider circuit is equal to or larger than the voltage value of the reference voltage set for a current divider circuit in the preceding stage, and sets one common control voltage for all of the current divider circuits, the common control voltage falling within a range that includes all of the reference voltages.

Abstract: A probe includes a movable plate to which a stylus capable of contacting a measurable object is mounted, the movable plate displaceable in an X direction; a static plate arranged to overlap with the movable plate; a counter plate facing the movable plate and the static plate; an elastic movable side connection plate, the movable side connection plate connecting the counter plate at at least three places with each of a first end connector positioned toward a first end of the movable plate in the X direction and second end connectors positioned toward a second end in the X direction; and a static side connection plate which connects the static plate and the counter plate. An entire length of the first end connector in a Y direction orthogonal to the X direction is the same size as the entire length of the second end connectors in the Y direction.

Abstract: A hot-dip galvanized steel sheet having a good appearance and good adhesion to a coating, the hot-dip galvanized steel sheet having a composition including, on a mass basis: C: 0.20% to 0.50%, Si: 0.1% to 3.0%, Mn: 0.5% to 3.0%, P: 0.001% to 0.10%, Al: 0.01% to 3.00%, and S: 0.200% or less, a remainder being Fe and incidental impurities, wherein the hot-dip galvanized steel sheet includes an internal oxidation layer and a decarburized layer, the internal oxidation layer having a thickness of 4 ?m or less, the decarburized layer having a thickness of 16 ?m or less, and 50% or more by area of the internal oxidation layer is composed of a Si oxide containing Fe and/or Mn represented by Fe2XMn2-2XSiOY, wherein X ranges from 0 to 1, and Y is 3 or 4.

Abstract: A lighting control device includes a sensor that detects a state of a user and a gesture made by the user and a controller that controls a lighting characteristic of a lighting device. In the lighting control device and/or the lighting control method, it is determined (by the controller) whether a gesture made by the user and acquired by the sensor matches a first predetermined gesture including a predetermined hand shape and a predetermined movement of both hands of the user made within a detecting region between a boundary 30% larger than a periphery of a projection region illuminated by the lighting device and a boundary 30% smaller than the periphery of the projection region. When it is determined that the gesture matches the first predetermined gesture, a size of the projection region is changed (by the controller).

Abstract: A mobile apparatus includes a main body, a range sensor, an operation device, and a mobile mechanism, The operation device includes a wide route data generation unit that generates a wide route data according to which the main body is moved from a first specified location to a second specified location, a determination unit that determines a location and a posture of a reference object, an approaching route data generation unit that generates an approaching route data according to which the main body is moved from the second specified location to a target location, and a route data switching unit that switches traveling route from the wide rote data to the approaching route data after the approaching route data is generated, The approaching route data generation unit generates the approaching route data while the main body is traveling according to the generated wide route data,

Abstract: A forklift capable of carrying a load placed on a pallet having two openings into which a fork of the forklift is inserted is provided. The forklift includes a sensor configured to irradiate laser light toward a predetermined space forward of the fork, and measure a distance from the sensor to an object located in the predetermined space based on reflected light of the laser light reflected by the object; and a processor configured to identify positions of sidewalls of the two openings of the pallet that is to be lifted based on distance data measured by the sensor, the processor being further configured to identify a center of a front surface of the pallet based on the positions of the sidewalls of the two openings.

Abstract: A galvannealed steel sheet having a galvanized layer on a surface thereof is provided, having a composition which contains C: 0.10% to 0.35%, Si: 0.3% to 3.0%, Mn: 0.5% to 3.0%, P: 0.001% to 0.10%, Al: 0.01% to 3.00%, and S: 0.200% or less on a mass basis, the remainder being Fe and incidental impurities. The steel sheet has a SiC/SiO2 ratio of more than 0.20, the SiC/SiO2 ratio being a ratio of SiC amount to SiO2 amount at a depth of 1 ?m or less in the steel sheet from an interface between the steel sheet and the galvanized layer, and Fe in the galvanized layer constitutes 8% to 13% by mass.

Abstract: A method for manufacturing a galvanized steel sheet includes heating a base steel sheet in a heating zone such that the surface of the base steel sheet is heated at a temperature of 600° C. or higher and 790° C. or lower while a furnace temperature T° C. in the heating zone of an annealing furnace is controlled based on the water vapor partial pressure PH2Oin Air of air fed into the heating zone, the base steel sheet having a chemical composition consisting of, by mass %, C: 0.05% or more and 0.25% or less, Si: 0.1% or more and 3.0% or less, Mn: 0.5% or more and 3.0% or less, P: 0.001% or more and 0.10% or less, Al: 0.01% or more and 3.00% or less, S: 0.200% or less, and the balance being Fe and inevitable impurities, heating the base steel sheet in the heating zone such that the surface of the base steel sheet is heated at a temperature of 630° C. or higher and 850° C.

Abstract: A photoelectric sensor includes a lens mounted to a light projecting element at a position that opposes a light projecting lens and configured such that the curvature in the direction perpendicular to a straight line passing through the center of the light projecting lens and the center of the light receiving lens is greater than the curvature in the direction parallel to the straight line passing through the center of the light projecting lens and the center of the light receiving lens.