Abstract: An oral capsule formulation of a PARP inhibitor and a preparation method. The oral capsule formulation comprises a solid dispersion powder of an active ingredient 5-fluoro-1-(4-fluoro-3-(4-(pyrimidin-2-yl)piperazine-1-carbonyl)benzyl)quinazoline-2,4(1H,3H)-dione, a filler, a disintegrant, a glidant, and a lubricant, wherein less than 10 wt. % of the active ingredient in the solid dispersion powder is in a crystalline form. The defects of the fluidity, hygroscopicity and cohesiveness of the solid dispersion powder which result in the difficulty of production scale up of capsule formulation are addressed, and thus commercial scale production can be achieved, and the prepared capsule exhibits proper dissolution rate, excellent storage stability, meanwhile with a reasonable production cost.

Abstract: The present invention is directed to electrical circuits and methods. According to a specific embodiment, the present invention provides a voltage compensation mechanism for one or more single-phone avalanche diodes (SPADs). A reference voltage is generated based at least on an operating voltage of the SPADs. The reference voltage is coupled to a charge pump that generates a compensation voltage for the diodes. There are other embodiments as well.

Abstract: Semiconductor devices and methods of forming the same are provided. In an embodiment, an exemplary semiconductor device includes a vertical stack of channel members disposed over a substrate, a gate structure wrapping around each channel member of the vertical stack of channel members, a source/drain feature electrically coupled to the vertical stack of channel members, a silicide layer formed on more than one side of the source/drain feature, and a source/drain contact electrically coupled to the source/drain feature via the silicide layer.

Abstract: A method of a polyurethane foam includes the following steps of: (1) simultaneously pumping a mixed solution prepared from hydrogen peroxide, an organic acid, a catalyst and a stabilizer and a vegetable oil into a first microstructured reactor of a micro-channel modular reaction device for reacting to obtain a reaction solution containing epoxidized vegetable oil; (2) simultaneously pumping the reaction solution containing the epoxidized vegetable oil obtained from the step (1) and a compound of formula III into a second microstructured reactor of the micro-channel modular reaction device for reaction to obtain a vegetable oil polyol; and (3) reacting the vegetable oil polyol prepared from the step (2) with a foam stabilizer, a cyclohexylamine, an isocyanate and a foaming agent cyclopentane for foaming so as to prepare a rigid polyurethane foam.

Abstract: A P2X3 and/or P2X2/3 receptor antagonist of formula (I), a pharmaceutical composition comprising the same, and a use thereof in preparing a drug for preventing or treating a disease mediated by the P2X3 and/or P2X2/3 receptor antagonist.

Abstract: A motor control circuit includes a first switch module, a three-phase inverter, and a control module. A power supply module, the first switch module, the three-phase inverter, and a three-phase alternating current motor form a current loop; midpoints of three phase legs of the three-phase inverter are respectively connected to three phase coils of the three-phase alternating current motor; the three-phase alternating current motor is configured to input or output a current by using a wire N extending from a connection point of the three phase coils; the control module is connected to the three-phase inverter, first switch module, three-phase alternating current motor, and power supply module; the control module is configured to control the three-phase inverter to enable the motor control circuit to receive a voltage of the power supply module and output a direct current, and to boost a voltage of the power supply module.

Abstract: A full-face shaft tunnel boring machine system includes a tunnel boring machine cutterhead device for tunneling downwards in a shaft; a full-hydraulic formwork device for supporting and walling in a wellbore; and an upper muck-discharge system for vertically conveying rock mucks generated by tunneling. The tunnel boring machine cutterhead device comprises a vertical guide frame, a cutter-expanded boring head and an advanced cutterhead that are fixedly connected in a vertical order from top to bottom so as to form an integrated structure. The vertical guide frame is a hollow cylindrical structure and driven to rotate around an axis of the vertical guide frame by a power mechanism, and an outer wall of the vertical guide frame is provided with multiple sets of first guide rollers.

Abstract: A damping ratio measuring device for consolidation equipment includes a bracket, a consolidation pressure device and a sleeve. The consolidation pressure device is set at the top of the bracket, and the output direction of the consolidation pressure device is directly below. The bottom of the consolidation pressure device is connected with a pressurized piston. A displacement sensor is set on the pressurized piston. The sleeve is set directly below the consolidation pressure device, the pressurized piston extends from the top of the sleeve, the diameter of the pressurized piston is the same as the inner diameter of the sleeve, the bottom of the sleeve is sealed with a support plate, and there are two bending element sensors at the top of the support plate and the bottom of the pressurized piston.

Abstract: A preparation method of a flexible polyurethane foam includes the following steps of: (1) subjecting an epoxidized vegetable oil, a benzoylformic acid, a basic catalyst, and an inert solvent to a ring-opening reaction in a first microchannel reactor of a microchannel reaction device to obtain a vegetable oil polyol; (2) subjecting the vegetable oil polyol obtained in the step (1), a propylene oxide and an inert solvent to an addition polymerization reaction in a second microchannel reactor of the microchannel reaction device to obtain a vegetable oil polyol for flexible polyurethane foam; and (3) using the vegetable oil polyol for flexible polyurethane foam obtained in the step (2) as the unique polyol, and subjecting the same and an isocyanate polyol to a foaming reaction to obtain the flexible polyurethane foam.

Abstract: Semiconductor device and the manufacturing method thereof are disclosed. An exemplary semiconductor device comprises a semiconductor stack including semiconductor layers over a substrate, wherein the semiconductor layers are separated from each other and are stacked up along a direction substantially perpendicular to a top surface of the substrate; an isolation structure around a bottom portion of the semiconductor stack and separating active regions; a metal gate structure over a channel region of the semiconductor stack and wrapping each of the semiconductor layers; a gate spacer over a source/drain (S/D) region of the semiconductor stack and along sidewalls of a top portion of the metal gate structure; and an inner spacer over the S/D region of the semiconductor stack and along sidewalls of lower portions of the metal gate structure and wrapping edge portions of each of the semiconductor layers.

Abstract: The present invention relates to a method for molding a self-supporting silk fibroin catheter stent, which comprises preparing an excellent catheter stent by a mold casting and freeze-drying molding process using silk fibroin as a raw material. The raw material is silk fibroin extracted from natural mulberry silk; and the mold is a hollow tubular mold, having an outer shell that is a transparent polyethylene straw with a diameter of 6 mm and an inner core that is a fiber rod FRP with a diameter of 3 mm, with the two ends being closed. The mold casting and freeze-drying molding process comprises the steps of casting; pre-freezing; removing the mold and placing the mold onto a pre-frozen freeze-drying plate; and freeze-drying. The freeze-drying procedure comprises: (1) a pre-freezing stage; (2) a freezing-vacuum transition stage; (3) a gradient temperature-rising and freeze-drying stage; and (4) a secondary freeze-drying stage.

Abstract: Provided are a display substrate and a display apparatus. The display substrate includes a base substrate, and an auxiliary cathode structure located on a side of the base substrate, the auxiliary cathode structure including a first conductive layer, an intermediate support layer, and a second conductive layer. In an implementation, a side of the intermediate support layer close to the first conductive layer includes any one or more of first protrusions and first grooves, and a side of the first conductive layer close to the intermediate support layer includes any one or more of second grooves engaged with the first protrusions and second protrusions engaged with the first grooves which are correspondingly disposed.

Abstract: A display substrate includes a driving circuit layer arranged on a base and a light emitting structure layer arranged on one side, away from the base, of the driving circuit layer; the light emitting structure layer includes an anode, a pixel definition layer, an organic light emitting layer, a cathode, and an auxiliary electrode; the pixel definition layer has a first pixel opening exposing the anode and a second pixel opening exposing the auxiliary electrode; the organic light emitting layer connected to the anode and the cathode connected to the organic light emitting layer are arranged in the first pixel opening; the organic light emitting layer separated from the auxiliary electrode and the cathode located on one side, away from the base, of the organic light emitting layer are arranged in the second pixel opening; and the cathode is connected to the auxiliary electrode in the second pixel opening.

Abstract: A full-face shaft tunnel boring machine system includes a tunnel boring machine cutterhead device for tunneling downwards in a shaft; a full-hydraulic formwork device for supporting and walling in a wellbore; and an upper muck-discharge system for vertically conveying rock mucks generated by tunneling. The tunnel boring machine cutterhead device comprises a vertical guide frame, a cutter-expanded boring head and an advanced cutterhead that are fixedly connected in a vertical order from top to bottom so as to form an integrated structure. The vertical guide frame is a hollow cylindrical structure and driven to rotate around an axis of the vertical guide frame by a power mechanism, and an outer wall of the vertical guide frame is provided with multiple sets of first guide rollers.

Abstract: A system may perform an uptapering process to cause a signal fiber to have a fiber core with a first uptapered thickness profile and a fiber cladding with a second uptapered thickness profile. The system may perform, after performing the uptapering process, an uptapering removal process to cause the fiber cladding of the signal fiber to not have the second uptapered thickness profile. The system may perform, after performing the uptapering removal process, a bundling process to bundle the signal fiber and a set of one or more pump fibers in a bundle configuration. The system may perform, after performing the bundling process, a bundle unification process to cause the bundle configuration to form a unified bundle configuration. The system may perform, after performing the bundle unification process, an attachment process to cause an end of the unified bundle configuration to attach to an end of an output fiber.

Abstract: A method for manufacturing a display panel includes: sequentially forming a conductive pattern, a light-emitting layer and a cathode layer on a substrate. The conductive pattern is formed by a one-time patterning process, and includes an auxiliary electrode layer. In a direction parallel to the substrate, both the first protective electrode and the second protective electrode in the auxiliary electrode layer extend over the metal electrode, a second orthographic projection of the second protective electrode on the substrate is within a first orthographic projection of the first protective electrode on the substrate, and an outer boundary of the second orthographic projection is staggered from an outer boundary of the first orthographic projection. The cathode layer is in contact with the first protective electrode and a sidewall of the metal electrode.

Abstract: A computer includes a processor and a memory storing instructions executable by the processor to predict a time to failure of a vehicle component according to a damage model generated from vehicle operating data, based on the predicted time to failure, retrieve a schematic of the vehicle component and input the schematic to an additive printer to manufacture a replacement vehicle component, and replace the vehicle component with the replacement vehicle component according to maintenance instructions that, based at least in part on the predicted time to failure, specify a time and location to replace the vehicle component.

Abstract: This patent application relates to a feeding device for tubular component, which comprises: a first driver and a first wheel set; and, a second driver and a second wheel set; wherein, the tubular component can be clamped between the first and second wheel sets, and be driven to move under the friction action of the first and second wheel sets; the first wheel set has a plurality of first driving wheels, travelling directions of which are parallel to each other, and form an angle with an extension direction of a clamped portion of the tubular component, the angle being an acute angle; the second wheel set has a plurality of second driving wheels, travelling directions of which are parallel to each other. The technical solution of the present application involves a simple structure, low cost, and ingenious principle, and has applicability to both rigid and flexible tubular components.

Abstract: The present disclosure relates to devices, methods, and computer-readable medium for providing recommendations for alternate resources to use for cloud services. The devices, methods, and computer-readable medium may receive a resource allocation request for a new resource of a computing system and may predict an occurrence of a capacity related allocation for the resource allocation request. The devices, methods, and computer-readable medium may identify alternate resources to use for the resource allocation request and may provide recommendations with the alternate resources.

Abstract: The present disclosure provides a display substrate, a manufacturing method thereof and a display device. The present disclosure includes a driving circuit layer disposed on a substrate and a light emitting structure layer disposed at one side of the driving circuit layer away from the substrate, wherein the light emitting structure layer includes an anode, an organic light emitting layer, an organic light emitting block, a cathode and an auxiliary electrode, the organic light emitting layer is connected to the anode and the cathode respectively, the auxiliary electrode includes a bottom surface at one side close to the substrate, a top surface at a side away from the substrate and a side surface arranged between the bottom surface and the top surface.