Abstract: The present invention relates to the efficient solid-phase synthesis of liraglutide represented by Formula-I. The present invention relates to an efficient process for the preparation of liraglutide by sequential coupling employing solid phase approach. It involves sequential coupling of protected amino acids to prepare backbone of liraglutide and upon completion of linear sequence, synthesis was extended from lysine side chain by adding ?-glutamic acid and palmitic acid, followed by removal of protective groups, cleavage of the peptide from solid support and purification of crude liraglutide obtained. The present invention also involves the usage of inorganic salts during the coupling, wash with HOBt in DMF solution after Fmoc-deprotection step to suppress the aggregation of peptides and ensure reactions are going for completion, and thus avoid deletion sequences and improve the process yield.

Abstract: A system for automated material master data harmonization that is extremely configurable and easy-to-use solution to standardize, normalize, attribute, rationalize and enrich the organization's material master data using embedded knowledge that leverages enterprise knowledge assets. The system provides various customer centric systems and processes by providing harmonization of data with dependencies of important embodiments such as data classification and MFR-MPN extraction that are not dependent on any other stage. Attribute extraction is dependent on data classification and data sheet definition. Post processing is dependent on data classification, data sheet definition and attributes extraction. Identify L2 dups is dependent on data classification, data sheet definition, attribute extraction and post processing. Non-Source enrichment and Identify L1 dups are dependent on MFR-MPN extraction.

Abstract: The present invention relates to the efficient solid-phase synthesis of liraglutide represented by Formula-I. The present invention relates to an efficient process for the preparation of liraglutide by sequential coupling employing solid phase approach. It involves sequential coupling of protected amino acids to prepare backbone of liraglutide and upon completion of linear sequence, synthesis was extended from lysine side chain by adding ?-glutamic acid and palmitic acid, followed by removal of protective groups, cleavage of the peptide from solid support and purification of crude liraglutide obtained. The present invention also involves the usage of inorganic salts during the coupling, wash with HOBt in DMF solution after Fmoc-deprotection step to suppress the aggregation of peptides and ensure reactions are going for completion, and thus avoid deletion sequences and improve the process yield.

Abstract: A gateway provides duplex-directional, multimedia ad hoc mesh networking, peer-to-peer direct communications, power optimization, dynamic configuration, and data management, while operating within various devices and network topologies. A multitasking virtual machine monitor for mobile networked devices, that is capable of functional expandability and portability to various operating environments, interoperability with a variety of operating systems, the Gateway Control System (GCS) performs functional capabilities in both a local and a networked topology using local and remote hardware and software. Software within the GCS is partitioned into sequentially, autonomous code, referred to herein as “modules,” each module being configured to communicate with hardware and other gateway modules. Collectively, all gateway modules are referred to herein as the gateway stack (GS). Each member of the GS can be turned on or off, downloaded from a remote site, and dynamically configured.

Abstract: A gateway provides duplex-directional, multimedia ad hoc mesh networking, peer-to-peer direct communications, power optimization, dynamic configuration, and data management, while operating within various devices and network topologies. A multitasking virtual machine monitor for mobile networked devices, that is capable of functional expandability and portability to various operating environments, interoperability with a variety of operating systems, the Gateway Control System (GCS) performs functional capabilities in both a local and a networked topology using local and remote hardware and software. Software within the GCS is partitioned into sequentially, autonomous code, referred to herein as “modules,” each module being configured to communicate with hardware and other gateway modules. Collectively, all gateway modules are referred to herein as the gateway stack (GS). Each member of the GS can be turned on or off, downloaded from a remote site, and dynamically configured.

Abstract: A data processing system for automated design of a piping system and method thereof are disclosed. In one embodiment, a method for automated design of a piping system includes obtaining logical definition data of the piping system with pipe runs from a computer-aided design (CAD) database, and computing a piping path for said each pipe run based on the logical definition data of the piping system. The method includes determining positions of the piping components required for said each pipe run according to the logical definition data based on the computed piping path, and associating the piping components for said each pipe run with the determined positions of the piping components. Moreover, the method includes automatically generating a graphical model of the piping system with the pipe runs based on the association of the piping components with the determined positions for said each pipe run.

Abstract: Pressure sensing guidewire assemblies are described herein where the guidewire assembly may be comprised of an elongate guidewire body and multiple pressure sensors secured near or at a distal end of the guidewire body. The signals obtained from the guidewire connectors and aortic sensor modules may be synchronized to minimize signal acquisition delays. The signals may be further processed to equalize the pressure waveforms by shifting the connector waveform to align correctly with the aortic module waveform and improve output signals.

Abstract: A hands-free wireless wearable GPS enabled video camera and audio-video communications headset, mobile phone and personal media player, capable of real-time two-way and multi-feed wireless voice, data and audio-video streaming, telecommunications, and teleconferencing, coordinated applications, and shared functionality between one or more wirelessly networked headsets or other paired or networked wired or wireless devices and optimized device and data management over multiple wired and wireless network connections. The headset can operate in concert with one or more wired or wireless devices as a paired accessory, as an autonomous hands-free wide area, metro or local area and personal area wireless audio-video communications and multimedia device and/or as a wearable docking station, hot spot and wireless router supporting direct connect multi-device ad-hoc virtual private networking (VPN).

Abstract: Assembly methods and apparatus for electrically stable connectors are described herein where a conductive wire assembly generally comprises an insulative substrate having a length, one or more conductive elements formed along a first direction upon the substrate, an insulative coverlay formed upon the one or more conductive elements, and at least one opening or window defined through the insulative coverlay exposing a portion of the one or more conductive elements. A conductive coating is formed upon the insulative coverlay such that the conductive coating is in contact with the portion of the one or more conductive elements through the at least one opening or window and the conductive coating may have at least one region removed along a second direction in proximity to the at least one opening or window such that one or more conductive pads are formed and are electrically isolated from a remainder of the conductive coating.

Abstract: Guidewires having conductive elements are described where in one variation, the guidewire may be formed by disposing an insulative layer upon a surface of the guidewire core, and printing one or more conductive traces directly upon a surface of the insulative layer.

Abstract: A hands-free wireless wearable GPS enabled video camera and audio-video communications headset, mobile phone and personal media player, capable of real-time two-way and multi-feed wireless voice, data and audio-video streaming, telecommunications, and teleconferencing, coordinated applications, and shared functionality between one or more wirelessly networked headsets or other paired or networked wired or wireless devices and optimized device and data management over multiple wired and wireless network connections. The headset can operate in concert with one or more wired or wireless devices as a paired accessory, as an autonomous hands-free wide area, metro or local area and personal area wireless audio-video communications and multimedia device and/or as a wearable docking station, hot spot and wireless router supporting direct connect multi-device ad-hoc virtual private networking (VPN).

Abstract: Methods and systems for determining information about a vascular bodily lumen are described. An exemplary method includes generating an electrical signal, delivering the electrical signal to a plurality of excitation elements in the vicinity of the vascular bodily lumen, measuring a responsive electrical signal from a plurality of sensing elements in response to the delivered electrical signal, and determining a lumen dimension. Specific embodiments include generating a multiple frequency electrical signal. Another embodiment includes measuring a plurality of responsive signals at a plurality of frequencies. Still other embodiments include using spatial diversity of the excitation elements. Yet other embodiments use method for calibration and de-embedding of such measurements to determine the lumen dimensions. Diagnostic devices incorporating the method are also disclosed, including guide wires, catheters and implants.

Abstract: A gateway provides duplex-directional, multimedia ad hoc mesh networking, peer-to-peer direct communications, power optimization, dynamic configuration, and data management, while operating within various devices and network topologies. A multitasking virtual machine monitor for mobile networked devices, that is capable of functional expandability and portability to various operating environments, interoperability with a variety of operating systems, the Gateway Control System (GCS) performs functional capabilities in both a local and a networked topology using local and remote hardware and software. Software within the GCS is partitioned into sequentially, autonomous code, referred to herein as “modules,” each module being configured to communicate with hardware and other gateway modules. Collectively, all gateway modules are referred to herein as the gateway stack (GS). Each member of the GS can be turned on or off, downloaded from a remote site, and dynamically configured.

Abstract: A hands-free wireless wearable GPS enabled video camera and audio-video communications headset, mobile phone and personal media player, capable of real-time two-way and multi-feed wireless voice, data and audio-video streaming, telecommunications, and teleconferencing, coordinated applications, and shared functionality between one or more wirelessly networked headsets or other paired or networked wired or wireless devices and optimized device and data management over multiple wired and wireless network connections. The headset can operate in concert with one or more wired or wireless devices as a paired accessory, as an autonomous hands-free wide area, metro or local area and personal area wireless audio-video communications and multimedia device and/or as a wearable docking station, hot spot and wireless router supporting direct connect multi-device ad-hoc virtual private networking (VPN).

Abstract: Methods and systems for determining information about a vascular bodily lumen are described. An exemplary method includes generating an electrical signal, delivering the electrical signal to a plurality of excitation elements in the vicinity of the vascular bodily lumen, measuring a responsive electrical signal from a plurality of sensing elements in response to the delivered electrical signal, and determining a lumen dimension. Specific embodiments include generating a multiple frequency electrical signal. Another embodiment includes measuring a plurality of responsive signals at a plurality of frequencies. Still other embodiments include using spatial diversity of the excitation elements. Yet other embodiments use method for calibration and de-embedding of such measurements to determine the lumen dimensions. Diagnostic devices incorporating the method are also disclosed, including guide wires, catheters and implants.

Abstract: A gateway provides duplex-directional, multimedia ad hoc mesh networking, peer-to-peer direct communications, power optimization, dynamic configuration, and data management, while operating within various devices and network topologies. A multitasking virtual machine monitor for mobile networked devices, that is capable of functional expandability and portability to various operating environments, interoperability with a variety of operating systems, the Gateway Control System (GCS) performs functional capabilities in both a local and a networked topology using local and remote hardware and software. Software within the GCS is partitioned into sequentially, autonomous code, referred to herein as “modules,” each module being configured to communicate with hardware and other gateway modules. Collectively, all gateway modules are referred to herein as the gateway stack (GS). Each member of the GS can be turned on or off, downloaded from a remote site, and dynamically configured.

Abstract: Assembly methods and apparatus for electrically stable connectors are described herein where a conductive wire assembly generally comprises an insulative substrate having a length, one or more conductive elements formed along a first direction upon the substrate, an insulative coverlay formed upon the one or more conductive elements, and at least one opening or window defined through the insulative coverlay exposing a portion of the one or more conductive elements. A conductive coating is formed upon the insulative coverlay such that the conductive coating is in contact with the portion of the one or more conductive elements through the at least one opening or window and the conductive coating may have at least one region removed along a second direction in proximity to the at least one opening or window such that one or more conductive pads are formed and are electrically isolated from a remainder of the conductive coating.

Abstract: A gateway provides duplex-directional, multimedia ad hoc mesh networking, peer-to-peer direct communications, power optimization, dynamic configuration, and data management, while operating within various devices and network topologies. A multitasking virtual machine monitor for mobile networked devices, that is capable of functional expandability and portability to various operating environments, interoperability with a variety of operating systems, the Gateway Control System (GCS) performs functional capabilities in both a local and a networked topology using local and remote hardware and software. Software within the GCS is partitioned into sequentially, autonomous code, referred to herein as “modules,” each module being configured to communicate with hardware and other gateway modules. Collectively, all gateway modules are referred to herein as the gateway stack (GS). Each member of the GS can be turned on or off, downloaded from a remote site, and dynamically configured.

Abstract: A gateway provides duplex-directional, multimedia ad hoc mesh networking, peer-to-peer direct communications, power optimization, dynamic configuration, and data management, while operating within various devices and network topologies. A multitasking virtual machine monitor for mobile networked devices, that is capable of functional expandability and portability to various operating environments, interoperability with a variety of operating systems, the Gateway Control System (GCS) performs functional capabilities in both a local and a networked topology using local and remote hardware and software. Software within the GCS is partitioned into sequentially, autonomous code, referred to herein as “modules,” each module being configured to communicate with hardware and other gateway modules. Collectively, all gateway modules are referred to herein as the gateway stack (GS). Each member of the GS can be turned on or off, downloaded from a remote site, and dynamically configured.

Abstract: A system for automated material master data harmonization that is extremely configurable and easy-to-use solution to standardize, normalize, attribute, rationalize and enrich the organization's material master data using embedded knowledge that leverages enterprise knowledge assets. The system provides various customer centric systems and processes by providing harmonization of data with dependencies of important embodiments such as data classification and MFR-MPN extraction that are not dependent on any other stage. Attribute extraction is dependent on data classification and data sheet definition. Post processing is dependent on data classification, data sheet definition and attributes extraction. Identify L2 dups is dependent on data classification, data sheet definition, attribute extraction and post processing. Non-Source enrichment and Identify L1 dups are dependent on MFR-MPN extraction.