Abstract: The present invention discloses a new strain of Streptomyces sp. BICC 7522, its variants or mutants and use of the strain for the production of macrolides, process of production and purification of microlides.

Abstract: Process for the recovery of a macrolide in substantially pure form comprising: a) treatment of an impure or crude macrolide with water immiscible solvent, b) optional concentration of the mixture, c) treatment with ammonia gas to phase out impurities, d) separation of impurities, d) optional concentration of the phase containing the macrolide, f) loading on silica gel chromatography, optionally reversed phase or pretreated with silver, and elution of the macrolide, g) affording the macrolide in substantially pure form, h) optional repetition of step f) and g) to afford the macrolide in substantially pure form. The macrolide is preferably tacrolimus, immunomycin or sirolimus.

Abstract: A system and method for ablating a selected portion of a contact surface of biological tissue is provided. The system includes an elongated ablation sheath having a preformed shape adapted to substantially conform a predetermined surface thereof with the contact surface of the tissue. The elongated ablation sheath includes a non-permeable portion. The ablation sheath defines an ablation lumen sized to slideably receive an elongated ablative device longitudinally therethrough. The ablative device includes a flexible ablation element selectively generating an ablative field sufficiently strong to cause tissue ablation. Advancement of the ablation element slideably through the ablation lumen of the ablation sheath selectively places the ablation element along the ablation path for guide ablation on the contact surface when the predetermined surface is in strategic contact therewith.

Abstract: The present invention is directed, inter alia, to a switch comprising: (A) a superconducting material whose field cooled and zero field cooled ac permittivities differ from each other, and whose field cooled and zero field cooled ac susceptibilities differ from each other, in a range of temperature below the superconducting transition temperature of the material; (B) means for applying a static magnetic field to said material; (C) means for controllably applying to said material an oscillating magnetic field of a magnitude effective to convert said material from a state exhibiting filed cooled permittivity to a state exhibiting zero field cooled permittivity; and (D) means for applying to said material a heat pulse effective to convert said material from a state exhibiting zero field cooled permittivity to a state exhibiting field cooled permittivity, said switch operating between a superconducting zero field cooled state and a superconducting field cooled state.