Abstract: A developing method in a developer device having a developing roller configured to rotate within a housing, the developing roller having a first portion that is exposed through an opening of the housing, a second portion at which developer attached to the developing roller separates from the developing roller and a third portion between the first and second portions, and an elastic sheet in contact with the developing roller between the second and third portions of the developing roller, the method includes guiding airflow along a first airflow passage, which is formed in the housing and partially facing the second portion of the developing roller, and guiding airflow along a second airflow passage facing the third portion of the developing roller and adjacent to the first airflow passage.

Abstract: According to an embodiment, an image forming apparatus includes a housing, a developing roller, and a photosensitive drum. The developing roller includes an image area and a pair of non-image areas. The image area extends along an axial direction the developing roller. The non-image areas are provided on both sides in the axial direction with respect to the image area. The image forming apparatus further includes a regulating member. The regulating member covers a gap in positions which are aligned over the non-image area. The regulating member regulates air flow toward sides of the image area in the axial direction.

Abstract: A developer device includes a housing having an opening, a developing roller configured to rotate within the housing, the developing roller having a first portion that is exposed through the opening of the housing and a second portion at which developer attached to the developing roller separates from the developing roller, a first airflow passage formed in the housing, and a second airflow passage facing a third portion of the developing roller at a location of the developing roller between the first and second portions and connected to the first airflow passage.

Abstract: The present invention is related to a bispecific antibody or an antibody fragment thereof comprising an antigen binding domain that binds to a TRAILR2, and an antigen binding domain that binds to a PSMA; a nucleic acid comprising a nucleotide sequence that encodes the antibody or the antibody fragment thereof; a recombinant vector comprising the nucleic acid; a transformant comprising the recombinant vector; a method for producing the bispecific antibody or the antibody fragment thereof by using the transformant; and a reagent for detection or measurement, a diagnostic agent, and a therapeutic agent, each of which comprises the bispecific antibody or the antibody fragment thereof.

Abstract: A vent piece for a vent channel of a tire vulcanization mold includes a cylindrical tube formed to be installed in a cavity end portion of a vent channel of a tire vulcanization mold and having a through hole extending in axial direction of the channel, and a plug positioned in the through hole and moves between closed and open positions. The plug has a second bearing surface facing a first surface of the tube such that the second surface of the plug makes contact with the first surface to close the channel in the closed position and the second surface is separated from the first surface to open the channel in the open position, and the first and/or second surfaces has a film formed at least on a portion of the first and/or second surfaces such that the film reduces friction between the first and second surfaces.

Abstract: The present invention relates to a multivalent antibody comprising multiple heavy chain variable regions of antibody linked to each other via a linker comprising an amino acid sequence encoding an immunoglobulin domain or a fragment thereof.

Abstract: The present invention relates to a multivalent antibody comprising multiple heavy chain variable regions of antibody linked to each other via a linker comprising an amino acid sequence encoding an immunoglobulin domain or a fragment thereof.

Abstract: A developer device includes a housing having an opening, a developing roller configured to rotate within the housing, the developing roller having a first portion that is exposed through the opening of the housing and a second portion at which developer attached to the developing roller separates from the developing roller, a first airflow passage formed in the housing, and a second airflow passage facing a third portion of the developing roller at a location of the developing roller between the first and second portions and connected to the first airflow passage.

Abstract: A highly stable mutant of human IgG4 antibody is provided. Such antibody is an antibody in which the CH3 domain of human IgG4 is substituted with the CH3 domain of human IgG1 and which exhibits inhibited aggregate formation, an antibody in which the CH3 and CH2 domains of human IgG4 are substituted with the CH3 and CH2 domains of human IgG1, respectively, or an antibody in which arginine at position 409 indicated in the EU index proposed by Kabat et al. of human IgG4 is substituted with lysine and which exhibits inhibited aggregate formation.

Abstract: According to one embodiment, an analysis apparatus includes an acquisition unit and a processor. The acquisition unit acquires first information with a first time length between a first time and a second time. The first information is based on motion of an object person. The processor extracts multiple similarity points from the first information. The multiple similarity points are similar to each other in the first information. The processor calculates a time interval between the similarity points.

Abstract: A mutant of a potentially therapeutic anti-CD40 antibody is provided which mutant has reduced ADCC and CDC activities designed to be optimized as a pharmaceutical agent. A mutant of an agonistic anti-CD40 antibody, comprising mutation and/or substitution of at least one amino acid in the constant region to reduce the ADCC and/or CDC activities therein, and a mutant of an antagonistic anti-CD40 antibody, comprising at least one mutation or substitution in the constant region to reduce the ADCC and/or CDC activities therein, both mutants having at least a hinge region derived from a human IgG2.

Abstract: According to one embodiment, an information collection system comprises a transmitter, a receiver, and a processor. The transmitter emits a signal. The receiver receives the signal. The processor calculates a distance between the transmitter and the receiver from a strength of the signal received by the receiver. The processor calculating the distance between the transmitter and the receiver from the strength of the signal for each of the signals received during a first interval, and using an average distance as the distance between the transmitter and the receiver, the average distance being obtained by averaging the plurality of calculated distances.

Abstract: A high-strength steel sheet having improved HIC resistance and fracture resistance even when it is thick has a chemical composition comprising, in mass %, C: 0.02-0.07%, Si: 0.05-0.50%, Mn: 1.10-1.60%, P: at most 0.015%, S: at most 0.0030%, Nb: 0.005-0.030%, Ti: 0.005-0.020%, Al: 0.005-0.060%, Ca: 0.0005-0.0060%, N: 0.0015-0.0070%, at least one of Cu, Ni, Cr, and Mo in a total of greater than 0.1% to less than 1.5%, and a remainder of Fe and impurities and a steel structure composed of at least 10% by area of bainite and a remainder of ferrite and pearlite. The degree of segregation is less than 1.6 for Nb and less than 1.4 for Mn in the central portion of the thickness of the steel sheet.

Abstract: A vent piece for a vent channel of a tire vulcanization mold includes a cylindrical tube formed to be installed in a cavity end portion of a vent channel of a tire vulcanization mold and having a through hole extending in axial direction of the channel, and a plug positioned in the through hole and moves between closed and open positions. The plug has a second bearing surface facing a first surface of the tube such that the second surface of the plug makes contact with the first surface to close the channel in the closed position and the second surface is separated from the first surface to open the channel in the open position, and the first and/or second surfaces has a film formed at least on a portion of the first and/or second surfaces such that the film reduces friction between the first and second surfaces.

Abstract: In the present invention, a honeycomb structure includes a joined honeycomb segment body in which a plurality of honeycomb segments are integrally joined by mutual joining surfaces via a joining material layer, and has a configuration in which a plurality of cells to become through channels of a fluid are arranged in parallel with one another along a central axis direction. The joining material layer contains, as aggregates, inorganic particles, and acicular crystal particles having a shot content ratio smaller than 10 mass %, and the acicular crystal particles include 80 mass % or more of acicular crystal particles having an average length of 20 to 500 ?m in a long axis direction of the acicular crystal particles. As the inorganic particles, silicon carbide, cordierite, alumina, zirconia, yttria or the like can be used, and as natural acicular minerals, sepiolite, wollastonite, palygorskite or the like can be used.

Abstract: A method for manufacturing an optical device includes forming a mask on main surface of a first GaN layer such that the mask has one or more openings in first region on the main surface of the first layer, selectively growing first GaN in the opening such that core including the first GaN is formed on exposed portion of the first layer, forming an active layer on the core such that active region is formed, forming a second GaN layer on the active region, removing a portion of the mask covering second region, forming a first electrode in the second region on the first layer, forming a second electrode covering the second layer and extending onto the mask in third region on the first layer, forming a first pad on the first electrode, and forming a second pad in a pad-forming region of the second electrode in the third region.

Abstract: A simple manufacturing method for an organic electroluminescent panel in which organic electroluminescent elements are arranged and sealed by a sealing adhesive. The electroluminescent panel has excellent sealing properties and excellent durability as a result of the organic electroluminescent elements being adhered to one another by a heat-curable adhesive. The manufacturing method is for an organic electroluminescent panel in which at least a first electrode, an organic functional layer containing a light-emitting layer, an organic electroluminescent element having a second electrode, and a sealing substrate are bonded together on a substrate by the heat-curable adhesive.

Abstract: A honeycomb structure body having joining material layers of a stress relaxing function and joining strength equivalent to those of joining material layers of a conventional honeycomb structure body, and having an excellent heat shock resistance. A honeycomb structure body includes a plurality of honeycomb segments and joining material layers having a plurality of pores and joining the plurality of honeycomb segments in a state where the honeycomb segments are arranged adjacent to each other so that side surfaces of the honeycomb segments face each other. A ratio of the number of pores having a value of 1.2 or less which is obtained by dividing a maximum diameter of each of the pores by a minimum diameter of the each of the pores is 60% or more of the number of all the pores of each of the joining material layers.

Abstract: A highly stable mutant of human IgG4 antibody is provided. Such antibody is an antibody in which the CH3 domain of human IgG4 is substituted with the CH3 domain of human IgG1 and which exhibits inhibited aggregate formation, an antibody in which the CH3 and CH2 domains of human IgG4 are substituted with the CH3 and CH2 domains of human IgG1, respectively, or an antibody in which arginine at position 409 indicated in the EU index proposed by Kabat et al. of human IgG4 is substituted with lysine and which exhibits inhibited aggregate formation.

Abstract: The present invention relates to an antibody or an antibody fragment thereof which recognizes an extracellular domain of erbB3 and inhibit EGF-like ligand-dependent phosphorylation of erbB3, a DNA encoding the antibody or the antibody fragment thereof, a method of producing the antibody or the antibody fragment thereof, a therapeutic drug including the antibody or the antibody fragment thereof, and therapeutic application using the antibody or the antibody fragment thereof.