Patents by Inventor Olaf Ritzeler

Olaf Ritzeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders
    Patent number: 11827633
    Abstract: The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: August 23, 2021
    Date of Patent: November 28, 2023
    Assignee: Sanofi
    Inventors: Dirk Gretzke, Olaf Ritzeler, Uwe Heinelt, Volkmar Wehner, Friedemann Schmidt
  • SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS
    Publication number: 20220041596
    Abstract: The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: August 23, 2021
    Publication date: February 10, 2022
    Inventors: Dirk GRETZKE, Olaf RITZELER, Uwe HEINELT, Volkmar WEHNER, Friedemann SCHMIDT
  • Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders
    Patent number: 11130755
    Abstract: The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: September 28, 2021
    Assignee: SANOFI
    Inventors: Dirk Gretzke, Olaf Ritzeler, Uwe Heinelt, Volkmar Wehner, Friedemann Schmidt
  • SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS
    Publication number: 20200095242
    Abstract: The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: November 2, 2017
    Publication date: March 26, 2020
    Applicant: SANOFI
    Inventors: Dirk GRETZKE, Olaf RITZELER, Uwe HEINELT, Volkmar WEHNER, Friedemann SCHMIDT
  • SUBSTITUTED 2-(CHROMAN-6-YLOXYL)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20180148440
    Abstract: The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: July 6, 2017
    Publication date: May 31, 2018
    Inventors: Werngard CZECHTIZKY, John WESTON, Nils RACKELMANN, Michael PODESCHWA, Petra ARNDT, Klaus WIRTH, Heinz GOEGELEIN, Olaf RITZELER, Volker KRAFT, Patrice BELLEVERGUE, Gary MCCORT
  • Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals
    Publication number: 20170166548
    Abstract: The present invention relates to substituted chroman-6-yloxy-cycloalkanes of the formula (I) in which Ar, R1 to R4, p and q are as defined in the claims. The compounds of the formula (I) are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use in pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: March 8, 2017
    Publication date: June 15, 2017
    Inventors: Werngard CZECHTIZKY, John WESTON, Nils RACKELMANN, Volker KRAFT, Petra ARNDT, Klaus WIRTH, Heinz GOEGELEIN, Olaf RITZELER
  • 2-amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors
    Patent number: 9675606
    Abstract: The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: June 13, 2017
    Assignee: SANOFI
    Inventors: Alain Braun, Olivier Duclos, Gilbert Lassalle, Franz Lorge, Valerie Martin, Olaf Ritzeler, Aurelie Strub
  • DOTAM DERIVATIVES FOR THERAPEUTIC USE
    Publication number: 20170050988
    Abstract: A compound of formula (I), a stereoisomeric form thereof, or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein, is provided. The compounds of formula (I) are valuable pharmacologically active compounds and are suitable for the treatment of osteoarthritis. The preparation of the compounds of formula (I), their use as pharmaceuticals, and pharmaceutical compositions including them are also provided.
    Type: Application
    Filed: November 25, 2014
    Publication date: February 23, 2017
    Applicants: SANOFI, EUROPEAN MOLECULAR BIOLOGY LABORATORY
    Inventors: Hai-Yu HU, Marc NAZARE, Ngee HAN LIM, Danping DING-PFENNIGDORFF, Oliver PLETTENBURG, Olaf RITZELER, Hans-Paul JURETSCHKE, Joachim SAAS, Eckart BARTNIK, Peter FLORIAN, Ulrich WENDT, Carsten SCHULTZ, Hideaki NAGASE
  • SUBSTITUTED 2-(CHROMAN-6-YLOXYL)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20170037042
    Abstract: The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: April 5, 2016
    Publication date: February 9, 2017
    Inventors: Werngard CZECHTIZKY, John WESTON, Nils RACKELMANN, Michael PODESCHWA, Petra ARNDT, Klaus WIRTH, Heinz GOEGELEIN, Olaf RITZELER, Patrice BELLEVERGUE, Gary MCCORT
  • Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals
    Patent number: 9440941
    Abstract: The present invention relates to substituted chroman-6-yloxy-cycloalkanes of the formula (I) in which Ar, R1 to R4, p and q are as defined in the claims. The compounds of the formula (I) are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: September 13, 2016
    Assignee: Sanofi
    Inventors: Werngard Czechtizky, John Weston, Nils Rackelmann, Volker Kraft, Petra Arndt, Klaus Wirth, Heinz Goegelein, Olaf Ritzeler
  • Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals
    Publication number: 20160016928
    Abstract: The present invention relates to substituted chroman-6-yloxy-cycloalkanes of the formula (I) in which Ar, R1 to R4, p and q are as defined in the claims. The compounds of the formula (I) are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: March 7, 2014
    Publication date: January 21, 2016
    Applicant: SANOFI
    Inventors: Werngard CZECHTIZKY, John WESTON, Nils RACKELMANN, Volker KRAFT, Petra ARNDT, Klaus WIRTH, Heinz GOEGELEIN, Olaf RITZELER
  • 2-AMINO-3-(IMIDAZOL-2-YL)-PYRIDIN-4-ONE DERIVATIVES AND THEIR USE AS VEGF RECEPTOR KINASE INHIBITORS
    Publication number: 20150328205
    Abstract: The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.
    Type: Application
    Filed: July 24, 2015
    Publication date: November 19, 2015
    Inventors: Alain BRAUN, Olivier DUCLOS, Gilbert LASSALLE, Franz LORGE, Valerie MARTIN, Olaf RITZELER, Aurelie STRUB
  • 2-amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors
    Patent number: 9126972
    Abstract: The invention relates to the compounds of general formula (I): Preparation process and therapeutic use.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: September 8, 2015
    Assignee: SANOFI
    Inventors: Alain Braun, Olivier Duclos, Gilbert Lassalle, Franz Lorge, Valerie Martin, Olaf Ritzeler, Aurelie Strub
  • Crystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carboxylic acid [ (S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl ]-amide
    Patent number: 9067918
    Abstract: The present invention relates to polymorphs and hydrates of 2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carboxylic acid [(S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide, processes for their preparation and their use, in particular in pharmaceutical compositions.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: June 30, 2015
    Assignee: SANOFI
    Inventors: Olaf Ritzeler, Mandy Mohnicke, Guenter Billen, Bruno Baumgartner, Martin Brockelmann, Norbert Nagel
  • SUBSITUTED 2-(CHROMAN-6-YLOXYL)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20150087648
    Abstract: The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: November 10, 2014
    Publication date: March 26, 2015
    Inventors: Werngard CZECHTIZKY, John WESTON, Nils RACKELMANN, Michael PODESCHWA, Petra ARNDT, Klaus WIRTH, Heinz GOEGELEIN, Olaf RITZELER, Volker KRAFT, Patrice BELLEVERGUE, Gary McCORT
  • Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals
    Patent number: 8912224
    Abstract: The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: December 16, 2014
    Assignee: Sanofi
    Inventors: Werngard Czechtizky, John Weston, Nils Rackelmann, Michael Podeschwa, Petra Arndt, Klaus Wirth, Heinz Goegelein, Olaf Ritzeler, Volker Kraft, Patrice Bellevergue, Gary McCort
  • Crystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1H-Indole-5-carboxylic acid [ (S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino) -ethyl ] -amide
    Publication number: 20140336211
    Abstract: The present invention relates to polymorphs and hydrates of 2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carboxylic acid [(S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide, processes for their preparation and their use, in particular in pharmaceutical compositions.
    Type: Application
    Filed: December 4, 2012
    Publication date: November 13, 2014
    Inventors: Olaf Ritzeler, Mandy Mohnicke, Guenter Billen, Bruno Baumgartner, Martin Brockelmann, Norbert Nagel
  • SUBSITUTED 2-(CHROMAN-6-YLOXYL)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20140243292
    Abstract: The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
    Type: Application
    Filed: March 11, 2014
    Publication date: August 28, 2014
    Applicant: Sanofi
    Inventors: Werngard CZECHTIZKY, John WESTON, Nils RACKELMANN, Michael PODESCHWA, Petra ARNDT, Klaus WIRTH, Heinz GOEGELEIN, Olaf RITZELER, Volker KRAFT, Patrice BELLEVERGUE, Gary McCORT
  • Use of I?B-kinase inhibitors in pain therapy
    Patent number: 8809358
    Abstract: The present invention relates to the use of I?B-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: August 19, 2014
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Martin Michaelis, Olaf Ritzeler, Gerhard Jaehne, Karl Rudolphi, Gerd Geisslinger, Hans-Georg Schaible
  • Indole derivatives or benzimidazole derivatives for modulating IkB kinase
    Patent number: 8778955
    Abstract: The present invention relates to indole derivatives or benzimidazole derivatives, to processes for preparing such compounds, to pharmaceutical compositions comprising such compounds, and methods for the prophylaxis and therapy of a disease associated with an increased activity of I?B kinase comprising administering such compounds.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: July 15, 2014
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Gerhard Jaehne